... Many diseases are associated with changes to sHSPs occurring either as a result of mutation or by post-translational changes, and these are outlined below and described in the text of the review. ... actin filament modifications. Synthesis of exogenous human aA-crystallin in lens epithelial cells of the same species counters UVB-induced apoptosisby favoring action of the AKT kinase pathway, poten-tially ... Among the three cancers, sarcomacells possess the most Hsp25, the rodent equivalent of human Hsp27, and the protein builds up upon drugtreatment, suggestive of a role in cell survival. Inanother...