... heart and lung problems, while mice lacking otherEGF ligands, or even triple null mice deficient for amphiregulin, EGF and transforming growth factor-aare viable [4]. These ligands are synthesized ... respec-tively. The degrees of homology in the C-terminal reg-ulatory domain are relatively low, being 33, 24 and 28%, respectively.Structure of the ERBB proteins and diversity of their ligands The EGFR ... phosphatidylinositol 3-kinase ⁄ AKT and the signal transducer and activator of transcription(STAT)3 and STAT5 pathways (Fig. 2) [3]. These even-tually result in cell proliferation, migration and metas-tasis,...