Báo cáo khoa học: Quantitative modeling of triacylglycerol homeostasis in yeast – metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth potx
Báo cáo khoa học: Quantitative modeling of triacylglycerol homeostasis in yeast – metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth potx
... mobilization in yeast FEBS Journal 275 (2008) 555 2–5 563 ª 2008 The Authors Journal compilation ª 2008 FEBS 5563 Quantitative modeling of triacylglycerol homeostasis in yeast – metabolic requirement for lipolysis ... (LD)during periods of cellular growth [3]. In times of star-vation, esterified FA is then released by lipolysis and recycled into other lipids, or degraded via b-oxidation in order to provide the metabolic ... the role of TAGdegradation in growing cells and the metabolic flux of FA. We reconstructed the metabolic pathway of TAG lipolysis in yeast in silico and specifically addressed thequestion of whether...
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Báo cáo khoa học: Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screening docx
... synthesis under the control of the FUS1 promoter, allowing quantitative read-outs of the receptor–ligand interaction.Expression of olfactory receptors in yeast for screening J. Minic et al.526 FEBS ... Expression of olfactory receptors in yeast for screeningFEBS Journal 272 (2005) 52 4–5 37 ª 2004 FEBS 537Functional expression of olfactory receptors in yeast and development of a bioassay for odorant ... demonstrated that mRNA of the olfactory receptors is present in both uninduced and induced yeast cells (Fig. 1). This indicates a leak-age of GAL1 ⁄ 10 promoter in glucose-containing min-imal medium....
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Tài liệu Báo cáo khoa học: Quantitative analysis of the experimental O–J–I–P chlorophyll fluorescence induction kinetics Apparent activation energy and origin of each kinetic step Steve Boisvert, David Joly and Robert Carpentier doc
... quenching; PQ, plastoquinone; PS, photosystem; QA and QB, primary and secondary quinone acceptors of photosystem II; t1 ⁄ 2 O–J, t1 ⁄ 2 J–I and t1 ⁄ 2 I–P, half-times of O–J, J–I and I–P ... reduction of QA in DCMU-inhibitedPSII is accounted for by the O–J phase. Interestingly,this decrease of AJ–Iwas compensated for by theequivalent increase of AO–J, making the sum of contri-butions ... the quantitative parameters are discussed in terms of the origin of each kinetic phase.AbbreviationsAO–J, AJ–I and AI–P, amplitude of O–J, J–I and I–P phases, respectively; Chl, chlorophyll;...
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Tài liệu Báo cáo khoa học: Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli pdf
... success of binding to the enzyme of intermediates just made in the pathway and those in the aqueous cytoplasm will be proportional to theirrelative numbers. A method for calculating the fraction of ... channelingPrior investigations of channeling may be divided intotwo categories: in vitro and in vivo. The former includeexperiments with cell extracts and purified enzymes.These are inherently unsatisfying. ... unsatisfying. In particular, chan-neling is thought to be the result of protein–proteininteractions in the crowded, organized environment of the cell. Although investigators sometimes attempt to simulate...
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Báo cáo khoa học: Quantitative analysis of ultrasensitive responses pot
... (1994) Activation of overexpressed receptors for insulin and epidermal growth factor interferes in mitogenic signaling withoutaffecting the activation of p21ras. Biochemistry 33,745 3–7 459.44 Murphy ... 255, 354 2–3 551.33 Walker KS, Deak M, Paterson A, Hudson K, Cohen P& Alessi DR (1998) Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phos-phoinositide-dependent ... regulation of gene expression: tem-poral specificity in Ca2+, cAMP-responsive elementbinding proteins, and mitogen-activated protein kinasesignaling. J Neurosci 17, 725 2–7 566.Quantification of ultrasensitivity...
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Báo cáo khoa học: "Discriminative Modeling of Extraction Sets for Machine Translation" pptx
... chart pars-ing. In Computational Linguistics.Colin Cherry and Dekang Lin. 2006. Soft syntacticconstraints for word alignment through discrimina-tive training. In Proceedings of the Annual ... we include in- dicator features of fertility for common words.3We also include monolingual phrase featuresthat expose useful information to the model. For instance, English bigrams beginning ... Optimizingword alignment combination for phrase table train-ing. In Proceedings of the Annual Conference of theAssociation for Computational Linguistics: ShortPaper Track.Alexander Fraser and...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... differentiationwas initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum. Cells were fixed on day 4 of differentiation and stained with hematoxylin and eosin. ... suggesting that downregulation of miR-27 is not sufficient to promote adipogenesis.We performed a time course study to gain furtherinsights into the role of miR-27 during different stages of adipogenesis ... conditions.Expression of miR-27 is elevated in obese mice In order to gain insights into the potential biologicallyrelevant role of miR-27 in the regulation of adipose tis-sue functions in vivo, we examined...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... of aB-crystallin.Reduction-induced aggregation of the insulin B-chainLight scattering due to DTT-induced amorphousaggregation and precipitation of the insulin B-chaincommenced after 10 min ... main-tained at 37 °C for 30 min before being assayed. For the ANS binding studies, a stock solution of meth-anolic ANS (100 mm) was diluted 1000-fold into a0.1 mgÆmL)1protein solution in ... precipi-tation of insulin at intermediate and high concentra-tions, and it also increased the activity of aB-crystallin in preventing the aggregation leading to amyloid fibrilformation by a-synucleinA53T...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... cytosolic RNase inhibitor (cRI) plays a major role in determining theability of an RNase to be cytotoxic. However, to interact with cRI RNasesmust reach the cytosol, and cross intracellular membranes. ... (rotationangle ‘r’) and variation of the inclination (inclination angle ‘i’) withrespect to the plane of the membrane (parallel to the xy plane).Cter and Nter are the C-terminal and N-terminal structural ... distancebetween protein and membrane at 3.5 A˚.The EIE, i.e., the electrostatic contribution to the bindingenergy (DGbindingR ⁄ M) of RNase (R) to a lipidic membrane Electrostatic interactions and antitumor...
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Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf
... aC-terminal extension to the protein kinase folds backon the kinase domain and interferes with the substratebinding sites. In the case of the titin and twitchinkinases, the autoinhibitory sequence ... consisting of four copies of foursubunits, a, b, c and d. The a and b subunits are regu-latory and are the sites of phosphorylation and meta-bolite binding and are also regulated by the binding of ... PhKcsubunit encodes a C-terminal extension to the proteinkinase domain and treatment of the kinase withKeywordscalmodulin; kinase regulation; protein–protein interaction; NMR spectroscopyCorrespondenceJ....
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