Báo cáo khoa học: The effects of a-secretase ADAM10 on the proteolysis of neuregulin-1 pot
Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... other methods, because it enables one to develop a broader perspective of the questions within an analysis of the hypothesis in the con- text of a characterization of the "how" of ... result of acti- vation of a pragmatic representation of a disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension ... into a phonetic representation of words, along with the implications of the determined repre- sentation for our processing approach to compre- hension of French, will form the basis of the discussion....
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Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx
... Proceedings of the 13th Conference of the European Chapter of the Association for Computational Linguistics, pages 1–5,Avignon, France, April 23 - 27 2012.c2012 Association for Computational LinguisticsLanguage ... to continue processing the rest of the input data if the workflow is robust (i.e. makesuse of retry and parallelisation) and the error isconfined to a WS (i.e. it does not affect the rest of the ... re-quirement is fulfilled or not. The quality of the tools is not altered as they are deployed as WSswithout any modification. According to the eval-uation of the current version of the platform, mostrequirements...
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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx
... and E97 of the secondsubunit. The backbone NH group of R98 forms ahydrogen bond with the backbone CO of F102. Fur-thermore, the orientation of the side chain of the tworesidues brings the guanidinium ... interaction (Fig. 9B) [49]. The above discussion rationalizes the observed effects of the Y74W mutation in PfTIM on the stability of the dimeric structure and catalytic activity. Examination of the ... in the vicinity of the active site that serve to position the functional K12 residue. The network of key interactions spans the interacting subunits. The Y74W* mutation can perturb orientations...
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Tài liệu Báo cáo khoa học: Functional effects of deleting the coiled-coil motif in Escherichia coli elongation factor Ts pptx
... show the positions of the protruding coiled-coil motif (residues 187–226) and the C-terminal module. The terminal positions of the deletion of the coiled-coil motif and the insertion of the linker ... for the analysis to ensure that the concentrations of ligandswere maintained at a constant level during migration of the elongation factors, thereby favouring equilibriumconditions. The concentration ... indicate that the maximal rate of the mutantEF-Ts in protein synthesis in vivo is 70%ofthatofthewild-type EF-Ts. The studies of the effect of the EF-Ts mutation understarvation conditions suggest...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... posi-tioned in the connecting loops. Approximately one-third of all mutations in the BTK gene are missenseand some of these reduce the stability of the protein.This is exemplified by mutations ... substitution of the corresponding R25 in the pleckstrin homology(PH) domain also results in loss of function [16,17],thereby demonstrating related functions amongselected PH domains. Thus, from the ... organization of the domainsin BTK and Fig. 2 shows missense mutations (aminoacid substitutions) in a three-dimensional context in the various domains of BTK. Mutations affecting the R28 residue...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... otherenzymes in neurons. Alternatively, the inhibition of neuronal long-chain fatty acid oxidation could contrib-ute to body weight control. The roles of long-chainfatty acyl-CoAs and long-chain fatty ... effects on malonyl-CoAconcentration in the short-term [27]. Aside from the public health aspects of the affects of fructose on foodintake, these findings lend further support to the mech-anism ... is indicates that the hypotha-lamic region may specifically nutritionally controlmalonyl-CoA levels. Consistent with this is the closecorrelation with the hypothalamic levels of orexigenicand...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
... modu-lation of Ca2+oscillations by increasing agonist con-centration [44]. The dependences of the period of oscillations on the RPTP and Csk concentrationsalmost mirror each other, although there ... thatmirror stimulation or changes in the external condi-tions.We consider the time scale on which the total Srcconcentration (Stot) is conserved. Neglecting the con-centrations of dimers, S Á ... type expressions. When the Michaelis constantfor a particular reaction of the SFK (de)activationcycle is substantially larger than the concentration of the corresponding SFK form (or the total...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... preventdegradation. A common drawback of such approachesis the cost of the affinity resins used to isolate the fusion protein and the proteases required to liberate the protein of interest from the fusion ... using the devices and loss of peptide on the column resin. The only detriment of the peptidesproduced here is the fact that they contain an exo-genous N-terminal methionine. However, the presence of ... absorption of tyrosine at 275 nm(e275= 1400 m)1Æcm)1) was used to estimate the concentration of Ab in solution. In four separate puri-fication experiments, the concentration of Ab(M1–40)in the...
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Tài liệu Báo cáo khoa học: Antimicrobial effects of H4-(86–100), histogranin and related compounds – possible involvement of DNA gyrase ppt
... evaluate the rapidity of action of his-tone H4 peptides and compare it with that of the quinolone antibiotic ciprofloxacin, the LD50values of Fig. 2. ATP potentiation of the bactericidalactivity of ... to the mucous surface of epithelial cells toprevent the entry of bacteria into the epithelial layerand their invasion into the lower parts of the gastro-intestinal tract [7]. Their finding of ... attractive for further consi-deration.Potentiation of the antimicrobial activity of HNand related compounds by ATPInflammation caused by infection or wounds triggers the stimulation of neutrophils,...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... level of the untagged pro-teins, but we expect that the relative expression level of the tagged proteins is indicative of that of the equival-ent untagged proteins.To assess the function of these ... polarization is further evidence that the functions of Vrp1p in endocytosis, cytokinesis, and growth atelevated temperature, on the one hand, and in corticalactin-patch polarization, on the other ... comprise the LBD of Vrp1p[20,27–29]. We therefore tested if the LBD is importantfor various Vrp1p-dependent functions (Fig. 5A–C).To examine whether deletion of the LBD abolishes the function of...
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Từ khóa: tài liệu báo cáo khoa học bản chất của khủng hoảng kinh tế thế giới pdflam the nao de tom tat bao cáo khoa hocbáo cáo khoa họcbáo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ