Báo cáo khoa học: Oxidative stress induces a reversible ﬂux of cysteine from tissues to blood in vivo in the rat pptx

... various rat organs in order to assess whether dia-mide was also able to affect the thiol ⁄ disulfide bal-ance of these organs, and whether cysteine efflux to the blood was paralleled by a change ... cysteine from tissues to blood in vivo in the rat Daniela Giustarini1, Isabella Dalle-Donne2, Aldo Milzani2and Ranieri Rossi11 Department of Evolutionary Biology, Laboratory of Pharmacology ... for by efflux of GSH and Cys from the liver andother organs to maintain the cysteine pool. GSH isknown to be a critical source for maintaining a steadyCys availability as it is continuously...

Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc

... several changes in variables related to the generation and elimination of oxygen free radicals in adult rats [18,30]. An increase in free radical formation is accompanied by an imme-diate compensatory ... partic-ularly facilitated in the brain, as the brain containslarge quantities of oxidizable lipids and metals, and,moreover, has fewer antioxidant mechanisms thanother tissues [8].Free radicals ... all of which char-acterize oxidative stress. Our ﬁndings show that pilocarpine induces SE,which can produce alterations in superoxide dismutaseand catalase activities in different areas, thereby...

Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc

... In uence of Ca2+increase in combination with H ⁄ Randextramitochondrial NADH on respiration of brain mitochondria. Rat brain mitochondria (0.5 mgÆmL)1) were incubated at 30 °C in incu-bation ... Experimental procedures. State 4 respiration wasmeasured after the addition of substrates. State 3 respiration wasinduced by the addition of 200 lM ADP. The state 3 respiration of untreated rat brain ... reperfusion in brain.There is a growing body of information concerning the mechanism of ROS generation by the respiratorychain in mitochondria. Complex I and complex IIIwere identiﬁed as generators of...

Báo cáo khoa học: Ascorbic acid induces a marked conformational change in long duplex DNA doc

... Hamamatsu SIT TV camera, which allowedrecording of images on video tapes. The video image wasanalyzed with an image processor (Argus 20; HamamatsuPhotonics, Hamamatsu, Japan).Imaging by atomic ... Ascorbic acid induces a marked conformational change in longduplex DNAYuko Yoshikawa1,5, Mari Suzuki1, Ning Chen2, Anatoly A. Zinchenko2, Shizuaki Murata2,5,Toshio Kanbe3, Tonau ... charge in the volume part of compact DNA [26]. Thus, the remaining negative charge would make a signiﬁcant contri-bution to the stability of the compact state when the packingis less dense, as in...

Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx

... homologous to the CARD domain [41], mostly similar to the initi-ator caspases 2, 8, 9 and 10 [42]. The characteristicshave been described in Acasp from the sea anemone A. pallida [31]. Acasp (large and ... protostomes.Caspase-like activity and thermal stress After 2 days of heat stress, the increase in at least twocaspase-like activities detected in the animal tissue and the DNA fragmentation induction in ... anem-one, Aiptasia pallida, subjected to thermal stress [8,9],leading to the proposal of a new molecular pathway forbleaching induction. Furthermore, DNA cleavageanalysis [8,23] and increased expression...

Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx

... Thishastening of maturation was correlated with a preco-cious synthesis of Mos and AuroraA proteins, andwith the activation of the mitogen-activated proteinkinase (MAPK) (Fig. 4C). To conﬁrm these ... corresponding to amino acids269–350 from pADGal4 hRbm9 was inserted in frame withGal4AD into the Pst I site of the pADGal4 vector.pGBT9 AuroraA and pGADGH-p17 were providedby Y. Arlot-Bonnemains ... advice and assis-tance during the two-hybrid screen. We are grateful to Nicola Minshall and Nancy Standart for the tetheringassay constructs, and to Marvin Wickens and LabibRouhana for the gifts...

Báo cáo khoa học: "Creative Language Retrieval: A Robust Hybrid of Information Retrieval and Linguistic Creativity" pot

... SavantOur retrieval goals in IR are often affective in na-ture: we want to find a way of speaking about a topic that expresses a particular sentiment and car-ries a certain tone. However, affective ... unusual way. A query and a matchingphrase can be figuratively construed to have the same meaning if there is a non-literal mappingbetween the elements of the query and the ele-ments of the phrase. ... engine, precisely because it allowsusers to focus on the retrieval of matching phrasesrather than relevant documents. For instance, * canbe used to find alternate ways of instantiating a culturally-established...

Báo cáo khoa học: "GAMR VIEWED AS A FUNCTIONING PART OF A COGNITIVES SERM A YTM" pot

... support as separately definable knowledge within studies of aphasia. There is a vast literature concerning what aspects of language are indepen- dently affected in aphasia that has been used as a ... categories are activated via spreading activation that is the result of word meaning activation as words are recognized. Firing of an instance of a grammatical type activates that type's interpretation ... meaning in turn activates the category's meaning in the grammar space representation. Part of the grammatical meaning of any syn- tactic category is the meaning category that is expected...

Báo cáo khoa học: "Lexical surprisal as a general predictor of reading time" potx

... cor-pora. These probabilistic accounts of languageprocessing difﬁculty can then be validated againstempirical data, by taking reading time (RT) on a word as a measure of the effort involved in its ... R´ejean Ducharme, Pascal Vincent,and Christian Jauvin. 2003. A neural probabilis-tic language model. Journal of Machine LearningResearch, 3:1137–1155.Marisa Ferrara Boston, John Hale, Reinhold ... explainany variance in RT over and above the RNNs,suggesting that human processing relies on linearrather than hierarchical representations.Summing up, the only models taking into ac-count actual...

Báo cáo khoa học: "Extending Lambek grammars: a logical account of minimalist grammars" pot

... translates into application andeach introduction step into abstraction. Compo-sitionality assumes that each step in a derivationis associated with a semantical operation. In generative grammar ... by labeling each formula in the proof. Theselabels, that are called phonological and seman-tic features in the transformational tradition, arecomputed from the proofs and consist of two partsthat ... logical deﬁnition of Min-imalist grammars, that are Stabler’sformalization of Chomsky’s minimal-ist program. Our logical deﬁnitionleads to a neat relation to catego-rial grammar, (yielding a...

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