Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Blue-light active flavoproteins studied by electron paramagnetic resonance pptx
Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation pptx
... substrate protein[21–23]. The 19S caps are involved in recognition of the polyubiquitinated protein substrates, unfolding of the condemned protein [24], removing ubiquitin chainsfor recycling [25,26] ... Authors Journal compilation ª 2009 FEBSMINIREVIEW New roles of flavoproteins in molecular cell biology: Anunexpected role for quinone reductases as regulators of proteasomal degradationSonja Sollner ... isoform of ShcA, an adaptor protein that relays extracellularsignals downstream of receptor tyrosine kinases). Thelatter protein gives rise to increased levels of intracellu-lar ROS, thereby promoting...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Blue-light active flavoproteins studied by electron paramagnetic resonance pptx
... Journal compilation ª 2009 FEBS 4303MINIREVIEW New roles of flavoproteins in molecular cell biology: Blue-light active flavoproteins studied by electron paramagnetic resonance Erik Schleicher1, Robert ... are interacting only very weakly with theunpaired electron spin, e.g. protons from the proteinbackbone within the cofactor binding pocket, protons of water molecules surrounding the flavin, ... the positions of the two histidines wereassigned surprisingly accurately by ENDOR. His365(the analog amino acid of His354 in X. laevis)isindeed located in the binding pocket nearby the H(1¢)proton....
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot
... MINIREVIEW New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatinFederico Forneris1, Elena Battaglioli2, Andrea Mattevi1and Claudia Binda11 ... is in agreement with the domain organiza-tion in the first line. The third line shows a summary of the identified linear motifs (after filtering processing taking in account the accessibi-lity of ... in the eukaryotic cell nucleus, andbecause it is one of the first examples of the insertion of a protein–protein interaction module (the Towerdomain) into a highly conserved functional domain.Evolution...
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Tài liệu Báo cáo khóa học: New activities of a catalytic antibody with a peroxidase activity ppt
... of the Fe(II) spin state and noreplacement of any of the two axial ligands of the iron,His18 or RNO, by an amino acid side-chain of theantibody protein.Binding site topology of antibody 3A3Figure ... the binding of MP8 occurred through interactions of its carboxylate substituents with amino acids of theantibody, and that the protein provided a partial sterichindrance of the distal face of ... antibody proteininduced a regioselectivity of the nitration of phenol by NO2–/H2O2catalyzed by 3A3–MP8 in favor of the forma-tion of 2-nitrophenol [3]. Considering these findings, it wasreasonable...
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Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... potential of the haem, rate constants o f CO, O2and CN b inding tohaem, and CD spectra in the Soret region [15–18],suggesting that this residue is critical for maintaining theelectronic states of ... ncubated for 10 minprior to spectroscopic measurements.Cyanide bindingThe association rate of cyanide to haem was observed by monitoring changes at 417 nm in spectra of the haemprotein in 50 mMTris/HCl ... composed of two functional domains: an N-terminal haem-boundsensor domain and a C-terminal PDE catalytic domain[1,2]. Catalysis by this enzyme is regulated by the haemredox state in that PDE...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... counterparts, in agreement with thehigher mass of BChE subunits [37]. This indicates apredominant in uence of the catalytic domain onoligomerization.Role of the C-terminal cysteineMutation of the ... presence of this cys-teine retains the enzyme intracellularly. In case of Aa,the cellular activity of AChE was also decreased by approximately 50% but secretion was not modified,suggesting that ... modified,suggesting that degradation was increased by suppres-sion of the cysteine.Thus, it appears that the effect of a C-terminalcysteine on the trafficking of cholinesterase in thesecretory pathway largely...
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Báo cáo khoa học: Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature doc
... also beinvolved. In multicellular organisms, GATA-bindingfactors play critical roles in development, including cell- fate specification, regulation of differentiation, andcontrol of cell proliferation ... whereas the level of the c-T1 transcriptremained unchanged. Ninety-eight percent of the cellswere undergoing mitosis ⁄ cytokinesis at this time (asdetermined by counting of cells using a stereomicro-scope). ... atleast in part, by differential gene amplification and by the number of GATA-factor promoter motifs.Distribution of c-tubulins in E. focardii cellsTo examine the cellular distribution of c-tubulin,...
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Báo cáo khoa học: New application of firefly luciferase ) it can catalyze the enantioselective thioester formation of 2-arylpropanoic acid docx
... oxida-tion of firefly luciferin with molecular oxygen in thepresence of ATP and Mg2+, resulting in luminescence[1–3]. The stereoselectivity of this bioluminescent reac-tion was investigated in detail ... of ketoprofen and flurbiprofen were 9.5 min and13.2 min, respectively. Each assay was performed eighttimes. The kinetic parameters for racemic ketoprofen weredetermined by the method of Lineweaver–Burk ... produced by way of an acyl-adenylate intermediate.Kinetic analysis of LUC-H catalyzed thioesterformationThe kinetic study of the formation of ketoprofenyl-CoA catalyzed by LUC-H was examined...
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Báo cáo khoa học: Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S-transferases pdf
... andC-terminal domain, including the highly conservedGSH-binding site (G-site) and the more divergentcosubstrate-binding domain or hydrophobic bindingsite (H-site) [7,18]. The G-site includes ... arrangement of these elements is usuallybababba, similar to the thioredoxin fold of otherGSH-binding or cysteine-binding proteins. The H-siteis entirely helical, with a variable number of a-helices,depending ... according to the methoddescribed in Lo Piero et al. [11]. Briefly, protein expressionwas achieved in a cell- free system (Expressway Plus; Invitro-gen) by incubating the plasmids (15 lg), in IVPS...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... phase of the L99F mutant was independent of the O2concentration.bMeasurement of the rate of O2binding was notfeasible because of low heme binding affinity and instability of theprotein.ACBDFig. ... stableFe(II)–O2complex.CO binding kineticsWe next examined the kinetics of CO binding for themutant proteins of Ec DosH using laser flash photo-lysis (Fig. 6 and Table 4). The changes in the Soretregion of the ... [5]aMeasurement of the rate of CO binding was not feasible because of low heme binding affinity and instability of the protein.N. Yokota et al. Heme electronic states of Leu mutants of Ec DOSFEBS...
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