Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

... cloning, expression and function in tumor progression and metastasis. Nat Med 5, 793–802.23 Ilan N, Elkin M & Vlodavsky I (2006) Regulation, function and clinical signiﬁcance of heparanase in ... al. New concepts for heparanase function FEBS Journal 277 (2010) 3890–3903 ª 2010 The Authors Journal compilation ª 2010 FEBS 3903MINIREVIEW Proteoglycans in health and disease: new concepts for heparanase ... [23,25,30,31] and are not discussed in detail here. Heparanase in tumor progression and metastasis Enzymatic activity capable of cleaving glucuronidiclinkages and releasing polysaccharide chains resistantto...

Báo cáo khoa học: An a-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum Cloning and biochemical characterization of the enzyme potx

... important amino acidresidues lining these pockets. The active site amino acidresidues involved in substrate b inding were con served in Pf MDH but the N-terminal glycine motif, which is involved in ... theenzyme and the inhibitors were preincubated f or 10 min before i niti-ating the reaction by addition of NADH. Bovine heart LDH (j/solidline); Pf LDH ( d/broken line); Pf MDH (h/solid line); porcine ... (s/solid line); porc ine heart MDH (cytoso lic)(n/solid line).Table 3. Inhibition of P. falciparum and porcine MDH and LDH byoxamate and gossypol. The enzyme a ssays were performed with vary-ing...

Tài liệu Báo cáo khoa học: "You’ve Got Answers: Towards Personalized Models for Predicting Success in Community Question Answering" doc

... model.1 IntroductionCommunity Question Answering (CQA) has re-cently become a viable method for seeking infor-mation online. As an alternative to using general-purpose web search engines, information ... Weformalize this problem, and explore a varietyof content, structure, and interaction features for this task using standard machine learningtechniques. Our experimental evaluation overthousands ... theunderstanding of complex question answering, and explores evaluation issues in a new setting.The rest of the paper is organized as follows. Wedescribe the problem and our approach in Section2, including...

Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc

... amino acid side chains.Amino acid residues interacting with the guaninemoiety of GDP in EhPGKThe amino acid residues known to interact with theadenine moiety in the ADP ⁄ ATP-binding site in ... green) and E. his-tolytica PGK predicted model with GDP (red) obtained usingMOE software. (B) Close up of the purine ring binding site in theC-terminal domain. Lines indicate hydrogen bonds interactions. ... B); and Val339, Gly340 and Val341 (patch C).The corresponding reported amino acid residuesinvolved in adenine binding in the other crystallizedproteins, as well as in the EhPGK identiﬁed in...

Báo cáo khoa học: "LIMITS OF A SENTENCE BASED PROCEDURAL APPROACH FOR ASPECT CHOICE IN GERMAN-RUSSIAN MT" potx

... Berlin ABSTRACT In this paper we discuss some problems arising in German-Russian Machine Translation with regard to tense and aspect. Since the formal category of aspect is missing in German ... German main clauses into Russian including the decision of appropriate aspect forms for simple and complex verbal groups. We distinguish five different types of criteria all of them operating on ... whether a continuous process or a completed action is meant. This may be done by inserting an adverb into the sentence and asking the user whether the meaning remains unchanged. The following question...

Báo cáo khoa học: "A Hierarchical Approach to Encoding Medical Concepts for Clinical Notes" docx

... with empty in- stance in its subtree were removed from the training and testing stage.When training a classiﬁer for a node A in the tree,all the instances in the subtree rooted in the parent ... only source of training instances. For instance, code ‘786.0’ in Figure 2 uses all the 698 in- stances rooted in node ‘786’ as the full training dataset. The 98 instances rooted in node ‘786.0’ ... positive instances while the remaining 600instances in the tree as the negative ones. This hier-archical approach of distributing training instancescan reduce the size of training data set for...

Báo cáo khoa học: "Multi-Class Composite N-gram Language Model for Spoken Language Processing Using Multiple Word Clusters" pptx

... Word Clustering for Multi-Class2-grams For word clustering in class N-grams, POS in- formation is sometimes used. Though POS in- formation can be used for words that do not ap-pear in the corpus, ... clustering for 2-grams to3-grams, the clustering target in the conditionalpart is extended to a word pair from the singleword in 2-grams. Number of clustering targets in the preceding class increases ... wordto word . And the POS con-straints for clustering are the same as in the clus-tering for preceding words.4 Multi-Class Composite N-grams4.1 Multi-Class Composite 2-gramsIntroducing Variable...

Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

... lumican-evoked signaling,including vinculin and focal adhesion kinase [82].Lumican alters the relationship between actin ﬁlaments and b1 integrin, which in turn would affect focal adhe-sion formation, ... with the EGF-binding domain [32]. Thestructural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin is bio-logically ... reduction in tumor growth[50]. Notably, decorin also interferes with cross-talkbetween the EGFR and the androgen receptor in pros-tate carcinoma cells [50]. The interplay between deco-rin and the...

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

... (2010) Proteoglycans in health and disease: new concepts arising for heparanase func-tion in tumour progression and metastasis. FEBS J277, 3890–3903.118 Purushothaman A, Chen L, Yang Y & Sanderson ... (GAIP)-interacting C-terminus ⁄synectin and calc ium ⁄ calmodulin-associated serine kinase,since the C2 region contains a class II PSD-95 ⁄Discs-large ⁄ Zonula occludens protein-binding motifFXF, ... zinc. Interactionbetween cysteine–zinc maintains proMMPs in an inac-tive state by preventing a water molecule from bindingto the zinc atom. All MMPs, with the exceptionof MMP-7, MMP-23 and...

Tài liệu Báo cáo khoa học: DNA modiﬁcation with cisplatin affects sequence-speciﬁc DNA binding of p53 and p73 proteins in a target site-dependent manner pptx

... weakp53 binding (about 4% for mdm2 and PGM1 and 10% for p21).Sensitivity of the sequence-speciﬁc p53 DNAbinding to DNA cis-platination depends on theincidence of cisplatin-reactive motifs within ... targetsite, the intensity of the R53band resulting from p53 binding to unmodiﬁed DNA was taken as 1.0, and the intensities of bands correspond-ing to p53 binding to the same but cisplatin-treated ... withcisplatin on the binding of two p73 isoforms, p73d and p73b, to the p21 target site (Fig. 5). The intensity ofthe resulting R73dband decreased almost linearly withincrease in the cis-platination...

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