... ratHDC monomer and its quaternary structure, obtained afterdocking and energy minimization calculations carried outas described in the Materials and methods section. Onethousand dimer structures ... rats and its immunochemical and immunohistochemicalcharacterization. J. Biol. Chem. 259, 5214–5221.17. Ohmori,E.,Fukui,T.,Imanishi,N.,Yatsunami,K.&Ichikawa,A. (1990) Purification and characterization ... aminotransferase lowers its pKain the unligandedenzyme and is crucial for the successive increase in the pKaduringcatalysis. Biochemistry 37, 15076–15085.22. Guex, N. & Peitsch, M.C. (1997)SWISS-MODELand...