Báo cáo khoa học: Functional and genetic characterization of the promoter region of apolipoprotein H (b2-glycoprotein I) ppt
Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx
... two a-heliceson one side and three a-helices on the other side.Five equivalent subunits form a pentamer of the NHN H NNOOOOHOHOHOHOP OOHOHNHN H NN H OOOOHOHOHHONHN H NNOOOOHOHOHHOOP ... to the absence of the aliphatic chain bearing the phosphate moiety. Whereas the inhibitor TS13 iscomposed of the purinetrione system and the ribitylchain only, and is lacking the alkyl phosphate ... position of the pyrimidine ring, whereas the phos-phate and phosphonate moieties occupy the same posi-tion in spite of the different conformation of the alkylchain. The positions of the four hydroxyl...
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Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt
... collection and refinement statistics. Rsymm= R h Ri|I (h) ) Ii (h) | ⁄ R h RiIi (h) , where Ii (h) and I (h) are the ith and the meanmeasurements of the intensity of reflection h, respectively. ... [46]. The similarity in the Kmvalues is attributable to the uracil moiety bindingin the same fashion [38], which could trigger the initialbinding of both substrates. In UpG, the binding of the guanine ... by the uridine ribose. Of the two hydrogen bonds exhibited by these twoatoms, one is a direct interaction with the enzyme and the other is mediated by a water molecule. In the com-plex with...
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Tài liệu Báo cáo khoa học: Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1 docx
... aboutthree times higher than that of HYDBp, and five timeshigher than that of HYDPf(Table 1). As the activity of HYDPfat the whole-cell level was lower than that of HYDBp, even though it seems ... temperature of HYDJs of 50 °C for hydrolyzingd,l-p-HPH, which is the same as that for HYDBp[19]. The optimal pH for the hydrolytic activity of HYDJswas 7.6, slightly lower than that for HYDBp(pH ... solublethan HYDBp(data not shown), we concluded that the specific activity of HYDPfmay be less than that of HYDBp, and that it may not be worth further investi-gation. Therefore, the rest of the...
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Tài liệu Báo cáo khoa học: Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera pptx
... and rainbow (right). The N-terminus and C-terminus arelabeled in both monomers. On the left, the b-strands of the jellyrolldomain are labeled, with the BIDG sheets in yellow and the CHEFsheet ... in the binding of the fiberprotein in serotypes such as hAd2, which contain along hypervariable region. The long hypervariableloop could directly interact with the fiber protein, but the shorter ... reconstructions of complexes with soluble inte-grin and hAd12 gave more defined density in the region of the RGD motif due to the better order of the shorter hypervariable loop in this serotype [16].Higher-resolution...
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Tài liệu Báo cáo khoa học: Molecular and biochemical characterization ofD-phosphoglycerate dehydrogenase fromEntamoeba histolytica A unique enteric protozoan parasite that possesses both phosphorylated and nonphosphorylated serine metabolic pathways docx
... concentrations of the substrate, rEhPGDHshowed an approximately eightfold higher affinity toNADH than NADPH, and specific activity was aboutthreefoldhigherwithNADHthanwithNADPHinthereverse direction ... space of the active site cleft and are thought to be responsible for the binding to 3-PGA,which is highly negatively charged with the phosphate and carboxyl groups [17]. The amoebic PGDH also ... both PGDH and GDH sequences (datanot shown). The three methods consistently reconstructed the monophyly of Type IIA, Type IIB and Type III with100% BP supports as shown in the ML tree with the...
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Tài liệu Báo cáo khoa học: Bioinformatic and enzymatic characterization of the MAPEG superfamily doc
... FLAP forwhich the novel pattern is located in the third loop. The reason for the similarity and location of these pat-terns could be a result of short evolutionary timerather than gain of new ... identical to the fish sequences of other MAPEG families. The enzymatic properties of the pike MGST1-likeenzyme were extensively characterised (Table 1) dem-onstrating that the protein has the highest ... All of the remaining patterns are located at the end of first loop (Fig. 6). Both the first and third loopare located on the cytosolic side of the membrane and are regions earlier postulated to host...
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Tài liệu Báo cáo khoa học: Biochemical and molecular characterization of hazelnut (Corylus avellana) seed lipoxygenases pdf
... position 4235 of the genomic clone as the translation start. The characterization of other clonesrevealed the presence of another cDNA (CaLOX2) sharinghigh identity, 91.9%, with the CaLOX1. The comparison of ... evaluate the expression of other genes of the lipoxygenase pathway involved in oxylipin biosynthesis(allene oxide synthase, hydroperoxide lyase), will help toelucidate the role of the LOX pathway ... unclear. With the aim to betterclarify the occurrence of LOXs and their influence onhazelnut seed quality, we carried out the biochemical and molecular characterization of the main LOX isoformsexpressed...
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Báo cáo khoa học: Kinetic and mechanistic characterization of Mycobacterium tuberculosis glutamyl–tRNA synthetase and determination of its oligomeric structure in solution pptx
... concentrations of the other substrates(129 ± 28 min)1), within the limits imposed by the high value of the KL-Gluthat prevents an accurateestimate of this parameter, is now of the same order of magnitude ... sequence and the mass of the fragments, and from the kinetics of the process (Figs S7–S9 and Table S5)we concluded that the main sites of proteolytic cleav-age are at the C-terminus of the predicted ... that the concentration of one of the substrates was varied and the lev-els of the others fixed. In these assays the amount of enzymewas chosen in order to observe linearity up to 10 min, and aliquots...
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Báo cáo khóa học: Biochemical and molecular characterization of a laccase from the edible straw mushroom, Volvariella volvacea docx
... sequence of the lac1 protein exhibits verylow homology with sequences of other basidiomycetelaccases (Fig. 7).Although the spectral characteristics of the lac1 proteinsuggest the absence of a ... Kinetics of PCR amplification with the electrophoreticimage shown at the top. The cycle number(28·) that generates half maximal reaction wasused to analyse the expression of the gene.Right panel: ... molecularmass standards (Bio-Rad). The isoelectric point of the enzyme was determined with the Phastsystem using Phast-Gel IEF 3–9 operated for 410 Vh and standard pI markers(Pharmacia). The standard...
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Báo cáo khoa học: Isolation and enzymatic characterization of lamjapin, the first ribosome-inactivating protein from cryptogamic algal plant (Laminaria japonica A) ppt
... gel in the pH range 3–10 and the proteins were stained with Coomassie Brilliant Blue by the method of Neuhoff et al. [20]. The pI was determined bycalculating the linear regression of the marker ... but the sensitivity of these sitesto lamjapin was much lower than that of A4324 in the S/Rdomain.In order to confirm the multiple sites of depurination of lamjapin on the rat ribosomal RNA, the ... topographic structures of ribosomal RNA and the mechanism of protein synthesis[10]. Moreover, there is no consensus on the physiologicalfunction, distribution and the evolutionary links of RIPs.For...
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