... MINIREVIEW
Recent insights into cerebral cavernous malformations:
the molecular genetics of CCM
Florence Riant
1,2
, Francoise Bergametti
2
, Xavier ... identified
in the recent years. These molecular genetics data have
provided useful information for clinical care of the
patients and were an important step towards the
understanding of the mechanisms of...
... insights into cerebral
cavernous malformations: the molecular genetics of
CCM. FEBS J 277, 1070–1075.
11 Faurobert E & Albiges-Rizo C (2010) Recent insights
into cerebral cavernous malformations: ... hemor-
rhage. These features are reminiscent of the cancer ret-
inoblastoma, which led to the Knudson ‘two-hit’
hypothesis. Similarly, a two-hit hypothesi...
... Felbor U
(2008) Novel CCM1 , CCM2 , and CCM3 mutations in
patients with cerebral cavernous malformations: in-
frame deletion in CCM2 prevents formation of a
CCM1 ⁄ CCM2 ⁄ CCM3 protein complex. ... adhesion
The most recent articles strongly emphasize the role of
CCM proteins on the formation of cell–cell junctions.
However, we think that a control of the intera...
... proton from the catalytic Cys pres-
ent at the N-terminus of the helix to the His of the
dyad [19,50,51]. The first stage of catalysis is mediated
by the highly active thiolate ion of the Cys. Biochemi-
cal ... at the bottom of the subsite is conserved
in ervatamins. Compared to a Ser in the equivalent
position of papain, the role of Leu here is to restric...
... antibodies to the subunits of the yeast bc
1
complex indicated on the left side of the blots. The Western
blots are shown in panels A and B and the relative amounts of each of the subunits determined ... mutant
strain. However, the amounts of core protein 1 and core
protein 2 were relatively unaffected. Therefore, the absence
of subunit 6 appeared to alter the...
... molecules of the cofactor ThDP are bound in
the canonical V conformation at the interface between
the PYR domain and the PP domain of two subunits
of the functional dimer. The main chain oxygen of
G421 ... The main
chain nitrogens of residues I322 and I303 interact with
nitrogen atoms of the adenine ring and the c-carboxyl
group of the side chain of resid...
... systemic haemorrhage in mice.
These results emphasize the importance of the rapid
homing of RVV-X into microvessels to exert its effect.
The glycan structures of a number of venom glycopro-
teins ... sequenced. Of these, 10
clones were found to encode the LC2 and LC1 sub-
units. Others were found to encode other variants of
the C-lectin-like venom proteins. The amino...
... the
cytosol. This observation allows the further determination
of the concentration of drug free in the cytosol of resistant
cells.
The determination of k
a
requires also the measurement
of the ... the rate of passive diffusion of the dye through the
plasma membrane. This cannot be done by the simple
measurement of the increase of the fluorescence si...
... with the side-chain of
Lys101 [24]. Consistent with the reports of the selec-
tion of Lys101Glu in clinical use of efavirenz, the
crystal structure of RT with this NNRTI shows a
contact of the ... with a shift of 0.5 A
˚
relative
to wild-type. The result of these changes is the loss of
the salt bridge that links the protonated amino group
of Lys101 in t...
... X-organs of the two species, and analy-
sed the peptide content of the sinus glands by
MALDI-TOF mass spectrometry to check for the
presence of the peptides predicted from molecular
cloning. Furthermore, ... along the neurons of the
XO ⁄ SG system (Fig. 4A). Classically, the X-organ (the
grouping of perikarya in which the neuropeptides are
synthesized) is locate...