Báo cáo khoa học: Actin as target for modification by bacterial protein toxins docx
Báo cáo khoa học: Actin as target for modification by bacterial protein toxins docx
... al. Actin as target for toxin modification FEBS Journal 278 (2011) 4526–4543 ª 2011 The Authors Journal compilation ª 2011 FEBS 4543REVIEW ARTICLE Actin as target for modification by bacterial protein ... interaction with actin molecules is the basis for the rearrangement of the actin cytoskeleton by bacterial effectors like Salmonellainvasion protein A (SipA) and C (SipC). WhereasSipA decreases the ... concentration for F -actin formation leading to polymerization and stabilizationof F -actin filaments by acting as a molecular staple[16–18], the SipC functions as an actin nucleator andfilament bundling protein...
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Báo cáo khoa học: Homoadenosylcobalamins as probes for exploring the active sites of coenzyme B12-dependent diol dehydratase and ethanolamine ammonia-lyase docx
... ammonia-lyase [44] andribonucleotide reductase [29] and a weak competitiveinhibitor for methylmalonyl-CoA mutase [44]. 2¢-De-oxyAdoCbl is 31%, 17%, and 5–13% as active as Ado-Cbl for diol dehydratase ... 400 m)1Æcm)1 for dioldehydratase and ethanolamine ammonia-lyase, respectively.Based on the predicted molecular masses, e1%,280was calcu-lated to be 5.81 and 6.21 for the former and latter ... that for AdoCbl was used, low but distinct coenzyme activitywas observed with AdoMeCbl. As shown in Table 1, itskcatvalue was about 0.27% that for AdoCbl, and therate of mechanism-based...
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Báo cáo khoa học: "Heterogeneous Transfer Learning for Image Clustering via the Social Web" docx
... clustering tasks, including seven 2-way clustering tasks, two 4-way clustering task,one 5-way clustering task and one 8-way cluster-ing task. The detailed descriptions for these clus-tering tasks ... trainingtext as well as the translated target text together,in terms of the information theory. We allowed allthe information to be put through a ‘bottleneck’and be represented by a limited ... that the World WideWeb has many annotated images in Web sites such as Flickr (http://www.flickr.com), whichcan be used as auxiliary information source for our clustering task. In this work, our...
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Báo cáo khoa học: "A Formula Finder for the Automatic Synthesis of Translation Algorithms" docx
... determiner formulas. In a given context, the evaluation of a logical formula is determined by the specifications of the variables con- tained in that formula. There are several well known methods for ... logical rules for formula reduction are rigorous and machin- able. A computer program that reduces formulas given in disjunctive canonical forms to more economical normal forms is being prepared ... basic logical principles are treated, for example, in Refs. 7, 14, 15, 16, and 17. Machinable methods for reducing logical formulas to minimal normal forms, for resolving “don’t care” conditions,...
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Báo cáo khoa học: "Pre- and Postprocessing for Statistical Machine Translation into Germanic Languages" docx
... focus for SMT to date has been ontranslation into English, for which the models workrelatively well, especially for source languages thatare structurally similar to English. There has beenless ... sequencemodel based on part-of-speech, which potentiallycan improve word order and agreement. I take ad-vantage of available tools, such as the Moses toolkit(Koehn et al., 2007) for factored phrase-based ... suggested a corpus-based compound splitting method that has beenmuch used for SMT, where compounds are splitbased on corpus frequencies of its parts.If compounds are split for translation into...
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Tài liệu Báo cáo khoa học: Altered inactivation pathway of factor Va by activated protein C in the presence of heparin doc
... increases the Kmof APC for cleavage of FVa at Arg506 5.5-fold and at the same timedecreases the kcat2.6-fold, thus acting as a mixed-typeinhibitor of APC. As this analysis was performed ... homology modelbased on ceruloplasmin, formed by Asp659-Asp660-Asp661-Glu662-Asp663 may also play a role during thedocking of APC on to the FVa Arg506 site. In contrast,the segment containing ... contributions to protein protein interactions: fast ener-getic filters for docking and their physical basis. Protein Sci. 10,2147–2161.39. Xiang, Z., Soto, C.S. & Honig, B. (2002) Evaluating conforma-tional...
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Báo cáo khoa học: "Question Answering using Constraint Satisfaction: QA-by-Dossier-with-Constraints" docx
... appropriate. By defining broad enough classes of entities for which these questions might be asked (e.g. people, places, organizations and things, or major subclasses of these), we can for each ... manually derived for our prototype system, they are fairly general for the human life-cycle and can be easily reused for other, similar questions, or for more complex dossiers, as described ... subject X. By applying constraints, two possible effects can occur to these assertions: 1. Some works can get thrown out. 2. An asserted date (which was the top candidate from its associated...
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Tài liệu Báo cáo khoa học: "Learning Source-Target Surface Patterns for Web-based Terminology Translation" pdf
... Sessions,pages 37–40, Ann Arbor, June 2005.c2005 Association for Computational LinguisticsLearning Source -Target Surface Patterns for Web-based Terminology Translation Jian-Cheng Wu Department ... outperforms the state-of-the-art online machine translation systems. 1 Introduction Translation of terms has long been recognized as the bottleneck of translation by translators. By re-using ... terms can be saved. For many years now, Computer-Aided Translation (CAT) tools have been touted as very useful for productivity and quality gains for translators. CAT tools such as Trados typically...
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Báo cáo khoa học: "DATR AS A LEXICAL COMPONENT FOR PATR" pot
... be defined. For example, the lexical entry for frog would be FROG:<>==NOUN, where the noun-specific information is inherited from NOUN. This third approach forms the base for our current ... INFORMATION The formalism of PATR offers two possible means of representing lexical informa- tion. First of all, the information can be encod- ed in feature structures directly. Except for ... this, whereas default inheritance networks are well-suited for the purpose. In the following section we give an overview of one such network formalism which was primarily designed for representing...
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Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol pdf
... in the yeast. In contrast, activationof certain other clients (glucocorticoid receptor; extracellular signal-regu-lated kinase-5 mitogen-activated protein kinase) was less affected by thehuman ... kinase; GR, glucocorticoid receptor; HSF, heat shock transcription factor; Hsp90, heat shock protein 90;MAP kinase, mitogen-activated protein kinase; v-src, v-src tyrosine kinase; Y2H, yeast ... there-fore be a more cytoprotective form of Hsp90 [11].Hsp90a is also expressed to high level in many cancers[9], as well as extracellularly, where its effects on theactivity of metalloproteinase...
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