Báo cáo khoa học: "SYNTACTIC APPROACHES TO AUTOMATIC BOOK INDEXING" docx

Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modiﬁcations ppt

... common to organic synthesis but not yet amenable to proteinmodification. As new methodologies emerge, the studyof other PTMs and that of regulatory PTMs will hope-fully provide a powerful tool ... ARTICLEChemical approaches to mapping the functionof post-translational modificationsDavid P. Gamblin, Sander I. van Kasteren, Justin M. Chalker and Benjamin G. DavisChemistry Research Laboratory, Department ... leading to mixtures of modified pro-teins that may differ in function. In order to fully dis-sect the biological role of PTMs and determine precisestructure–activity relationships, access to pure...

Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf

... long day), we want to be able both to understand what makes proteins ÔtickÕ andtoengineerproteins with native-like properties.In this review we discuss combinatorial approaches toward understanding ... than NNNtoward Leu, Ser and Arg, and includes only one stopcodon). However, the natural repertoire of amino acids ishighly restrictive compared to the useful alterations that canbe made to small ... be tied to the survival of acell or some easy -to- observe phenotypic property. Ulti-mately, one would like to be able to study proteins whosefunctions are not necessarily critical to the survival...

Tài liệu Báo cáo khoa học: Computational approaches to understand a-conotoxin interactions at neuronal nicotinic receptors doc

... on the interaction ofa-conotoxins with neuronal nicotinic receptors in light of ournew understanding of the receptor structure. Computationaltools are expected to reveal the molecular recognitionmechanisms ... musclesubtype, thanks to the large amount of the receptorobtained from the electric organ of the Torpedo marmorataray and availability of selective pharmacological tools likethe snake a-neurotoxins. The ... determinantshave been mapped and a-conotoxins appear to bind mainly to loop C, but also clearly extend to microsites above thisloop and on the b9b10 hairpin. Indeed, a-conotoxins act atthe competitive...

Tài liệu Báo cáo khoa học: "Prosodic Aids to Syntactic and Semantic Analysis of Spoken English" ppt

... pause markers to segment the word string into intonationally- consistent groups, such as tone groups (bound- aries marked as = < = and "> ") and moves (//). A tone group is ... the three sentences varies tremendously, due to the top-down, depth-first nature of the parser. (6.3) took 2.05 seconds to parse, whereas (6.1) took 9.34 seconds, and (6.2), 41.78 seconds. ... exploit acoustic features to high- light the distinction that is to be conveyed to the listener (p. 450). Our current work incorporates certain prosodic information into the process of parsing,...

Tài liệu Báo cáo khoa học: "Syntactic Phrase Reordering for English-to-Arabic Statistical Machine Tranfor slation" pptx

... andRambow, 2005) respectively, to segment the Ara-bic side of their corpora. Other work on Arabic- to- English SMT tries to address the word reorder-ing problem. Habash (2007) automatically learnssyntactic ... feature to the Factored Model thatmodels noun case agreement and verb person con-jugation, and show that it leads to a more gram-matically correct output for English -to- Greek andEnglish -to- Czech ... one reading. These factors adversely affectthe performance of Arabic -to- English SMT, espe-cially in the English -to- Arabic direction.Simple pattern matching is not enough to per-form morphological...

Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

... HCT116 cells to proteasome inhibitors. Int JOncol 24, 935–941.19 Falchuk KH, Goetzl EJ & Kulka JP (1970) Respiratorygases of synovial ﬂuids. An approach to synovial tissuecirculatory–metabolic ... [2,3].Tumour necrosis factor-related apoptosis-inducingligands (TRAILs) are type II transmembrane mole-cules that trigger the apoptotic signal cascade by bind-ing to cognate receptors expressed on ... considered to be a key factor in thegrowth and survival of chondrocytes.Hypoxia is known to regulate the expression ofmany genes, but little is known about its role in eitherapoptosis or anti-apoptosis,...

Tài liệu Báo cáo khoa học: Calcium-binding to lens bB2- and bA3-crystallins suggests that all b-crystallins are calcium-binding proteins pptx

... binding to this crystallin by ITC anddetermined the binding constant for the calciummimic probe. Terbium is believed to bind strongly to calcium-binding sites of proteins compared to calciumdue to ... was grown in terriﬁcbroth to mid log phase at 37 °C. When the A600wasbetween 0.6 and 1.0, isopropyl thio-b-d-galactoside wasadded to the ﬁnal concentration of 1 mm to induce proteinoverexpression. ... these contradictory observations, it is important to investigate whether b-crystallins from vertebrate lensesbind calcium or not.In this context, to establish calcium-binding to theindividual...

Tài liệu Báo cáo khoa học: Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores pdf

... storage compartments for anumber of pro-death proteins, such as cytochrome c,which are released into the cytoplasm as a consequenceof apoptotic signals. The release of these apoptoticfactors ... normally found soluble in the cytoplasm, itsapoptotic activation includes extensive structural reor-ganization, which facilitates targeting to, and insertioninto, the mitochondrial outer membrane ... 2006 FEBScorresponding to Bid-a6, which has been shown previ-ously to be able to release calcein from PtdCho LUVs[28], assayed at L ⁄ P molar ratios up to % 5, wasunable to induce the release...

Tài liệu Báo cáo khoa học: From heart to mind The urotensin II system and its evolving neurophysiological role ppt

... receptor’s primary sequence shows stri-king similarities to the somatostatin receptor family,most notably in the transmembrane domains. Thepharmacological relatedness of somatostatin receptorsis ... receptor was initially considered to only couple Gaqproteins, the receptor seems to beinvolved in an array of interactions with other signa-ling molecules whose full spectrum remains to bedetermined.Tissue ... laboratory from ratsshow only diffuse URP mRNA expression in certainareas of the medulla oblongata that are not known to project to the PPT. There will be a need to produceselective tools...

Tài liệu Báo cáo khoa học: "Hierarchical Chunk-to-String Translation" ppt

... chunk -to- stringmodel into two models: a loose model (Section2.1) which is more similar to the hierarchicalphrase-based model and a tight model (Section2.2) which is more similar to the tree -to- stringmodel.The ... hierarchical chunk -to- stringmodel into two models: a loose model which is moresimilar to the hierarchical phrase-based model anda tight model which is more similar to the tree -to- string model. ... introducelinguistic knowledge into the hierarchical phrase-based model. Marton and Resnik (2008) took thesource parse tree into account and added soft con-straints to hierarchical phrase-based...

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