Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx

Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx

Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx

... modeled the complex by first placing C5 in the context of the gp120 core structure determined by X-ray crystallography [7]. The first three residues of the C5 domain used in the present study (amino ... in the gp120 X-ray structure; thus, the C5 domain can be overlaid with the C terminus of the gp120 X-ray structure (the RMSD of the NMR VKI ba...
Ngày tải lên : 08/03/2014, 16:20
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Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc

Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc

... 2001 geometry, the set of solutions reflects any uncertainty in the calibration as well as alternative fits to the set of distances. The main advantages of the procedure are simple: the details of the ... mobility with respect to the rest of the structure. Further studies of the receptor bound forms of the chimera and other related ligands will be necessary...
Ngày tải lên : 22/02/2014, 07:20
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx

Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx

... 28–38, connected by a regular type I b-turn. The surprising similarity of this structure, as well as the sequence of the C-terminal moiety, with those of the fusion domain of influenza hemagglutinin ... is the finding that the sequences of the C-terminal part of Ab-(1–42) and that of HA_fd share indeed a high similarity (Fig. 6C) dictated essentially by the pres...
Ngày tải lên : 08/03/2014, 09:20
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Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot

Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot

... significantly mod- ifying the secondary structural elements of the protein. One consequence of the presence of TFE on the structure of Vpr is the tertiary structure may open up. However, the NMR solution ... been clearly demonstrated by the loss of activity of Vpr following certain point mutations [16,38,39]. This is one of the main reasons why the aim of...
Ngày tải lên : 31/03/2014, 23:20
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Báo cáo Y học: Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein doc

Báo cáo Y học: Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein doc

... H N resonance of Ser4 is the most low-field shifted amide (Fig. 2). Solution structure of VVVV2KE The solution structure of VVVV2KE, represented by the ensemble of 20 energy-minimized DYANA conformers, consists ... structures. As with the NMR structure of VVVV2KE, the N-terminal cap structure of TTTT includes a hydrogen bond between the side chain carboxyl g...
Ngày tải lên : 31/03/2014, 21:21
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Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt

Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt

... The MBD of MBD1 contacts the methyl groups of a methylated CpG through a hydrophobic patch formed by the side chains of five residues, V20, R22, Y3 4, R44, and S45 [19]. Although the solution structure ... one-turn helix on the other face. It is thought that the two inner strands of the b-sheet lie within the major groove of the DNA and that a hydrophobic pocke...
Ngày tải lên : 21/02/2014, 00:20
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Báo cáo khoa học: Solution structure of the catalytic domain of RICH protein from goldfish pot

Báo cáo khoa học: Solution structure of the catalytic domain of RICH protein from goldfish pot

... similarity of the structures. The lowest-energy structure from the RICH NMR ensemble is used for the overlay. (D) The surface of the RICH catalytic domain shows several negatively charged patches of ... Secondary structure and the two catalytic motifs (*) are shown. (B) Representation of flexibility in the solution structure of the RICH catalytic domain....
Ngày tải lên : 07/03/2014, 10:20
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Báo cáo khoa học: Solution structure of the active-centre mutant I14A of the histidinecontaining phosphocarrier protein from Staphylococcus carnosus ppt

Báo cáo khoa học: Solution structure of the active-centre mutant I14A of the histidinecontaining phosphocarrier protein from Staphylococcus carnosus ppt

... back onto the core of the protein thereby allowing the side chain of Leu86 to partly fill the hole created by the removal of Ile14. Due to these changes other alterations are induced in the HPr(I14A) ... displays a kink towards the interior of the protein. The space that in the wild-type molecule is occupied by the large hydrophobic side chain of Fig. 3. Struct...
Ngày tải lên : 07/03/2014, 16:20
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Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf

Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf

... little direct effect on the activity of the enzyme. The function of this unique C-terminal domain remains unknown. Overall structure Crystals of the catalytic domain of hTRXL (hTRXL-N) were obtained ... pairs of hydrogen bonds are formed in the active site of hTRXL-N (Fig. 4), accounting for the compactness and stability of the active site. The H-bond lengt...
Ngày tải lên : 08/03/2014, 22:20
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Báo cáo khoa học: Solution structure of the bb¢ domains of human protein disulfide isomerase docx

Báo cáo khoa học: Solution structure of the bb¢ domains of human protein disulfide isomerase docx

... in the relative orientations of the a and b domains. In one struc- ture, the catalytic cysteines face each other; in the other, the catalytic residues of the a domain face away from the a¢ domain. ... Superimposition of the solution structure of the human PDI-b¢ (blue) with the crystal structure of yeast PDI-b¢ (red, Protein Data Bank entry code 2B5E). (...
Ngày tải lên : 16/03/2014, 04:20
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