Báo cáo Y học: Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider d-atracotoxin pdf
Báo cáo Y học: Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider d-atracotoxin pdf
... d-ACTX-Ar1 a nd -Hv 1a com-pletely inhibit the binding of classical scorpion a- toxins(e.g. Aah-II and Lqh-II) to rat brain synaptosomes as wellas the binding of LqhaIT to insect sodium channels [29,30]. ... association rate. The binding of 125I-labelled d-ACTX-Hv 1a to rat brain syna-ptosomes is inhibited c ompetitively by classical ScaTxs and allosterically by brevetoxin-1, similar to ScaTx binding. However, ... amount of membranes. Data were analysedusing the iterative programLIGAND(Elsevier B iosoft) u singÔcold saturationÕ or Ôhot saturationÕ analysis. The kineticdata for ligand association and...
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Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... of Fura-2 emissions were measured and analyzed usingphycoerythrinFWINLABsoftware. Ratiometric analysis wasconverted into a concentration of Ca2+ by measuring Rmax(maximal fluorescence in lysed, ... measuredtyrosine phosphorylation of the FcR c-chain and thetyrosine kinase Syk, which is tyrosine phosphorylated and activated early after GPVI engagement. Phosphorylation of FcR c-chain was assessed ... usingconvulxin and detected by ligand blotting as a band of 55 kDa.Additional bands of lower molecular mass are indicated. The associ-ated FcR c-chain was detected by Western blotting using a specificantibody....
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Báo cáo khoa học: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (AriceptÒ) to cholinesterases doc
... repeated atleast three times to obtain the values of the inhibitionconstants.Analysis of catalytic parametersThe catalytic parameters of wild-type and mutant AChE and BChE were compared by ... States.Structure-activity studies of this class of inhibitors haveindicated that both the benzoyl containing functionality and the N-benzylpiperidine moiety are the key features for binding and inhibition of ... Kawakami, Y. , Nakamura, T., Araki,S.,Yamanishi ,Y. &Yamatsu,K.(1990)Novelpiperidinederivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino) ethylpiperidine...
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Báo cáo y học: "Low socio-economic status, smoking, mental stress and obesity predict obstructive symptoms in women, but only smoking also predicts subsequent experience of poor health"
... All participants in the population study were physically examined and interviewed by physicians and research nurses. Information concerning education and socio-economic group was obtained ... measured as peak expiratory flow (PEF) by a peak flow meter in 1968-1969 and as PEF, vital capacity (VC) and forced expiratory volume in one second (FEV1) at the 2000-2001 examination. A 12-year ... such as mental stress, obesity and smoking among women are related to airway symptoms and also quality of life many years later. Key words: Population study, female, smoking, socio-economic status,...
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Báo cáo y học: "Advances in immunomodulating therapy of HBV infection"
... enhance clearance of HBV. In vitro studies have shown that thymosin α-1 can accelerate T-cell maturation and antigen recognition. It can also stimulate interferon and cytokine production and ... activity for lysis of infected hepatocytes and by stimulating cytokine production for control of viral replication. Nucleoside analogues on the other hand act by suppressing HBV replication at ... trial, peginterferon alfa- 2a (40KD) proved more effective than conventional interferon alfa in all efficacy parameters assessed (loss of HBeAg, normalization of serum ALT) [44]. A later study of...
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Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... by means of a DNA polymerase [34]. An alternative approach involves differential hybridization to a preexisting panel of membrane-bound probes as illustrated by the commercially available INNO-LiPA ... an additional compensatory mutation in the B subdomain [20], namely the substitution of a leucine by methionine some 20 amino acids upstream from the YMDD domain at position rtL180M. Finally, ... combined use of a genotyping assay for polymerase mutant detection and quantitative detection of viremia with a highly sensitive assay is warranted for optimal monitoring of HBV antiviral therapy...
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Tài liệu Báo cáo Y học: Mutations in the docking site for cytochrome c on the Paracoccus heme aa3 oxidase Electron entry and kinetic phases of the reaction pptx
... oxidase from Paracoccusdenitrificans. Nature 376, 660–669.12. Tsukihara, T., Aoyama, H., Yamashita, E., Tomizaki, T.,Yamaguchi, H., Shinzawa-Itoh, K., Nakashima, R., Yaono, R. &Yoshikawa, ... sequence by another aromatic sidechain, Y1 22. Table 1 summarizes the kinetic effects of single mutations in either residue, and of several doublemutants, indicating that in no case any major changes ... double-exponential decay wasplotted against the cytochrome c concentration, and theapparent bimolecular rate constant k on calculated from theslope.RESULTSThe large, periplasmically oriented hydrophilic...
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Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
... plotted as a function of free protein (lg/mL). The con-centrations of Myr2Gro-PCho and TO in lipid emulsion fraction6are110lM and 390 lM, respectively. Binding data was obtained by analytical ... extrusion, and fractionated by sucrose gradient ultracentrifugation [29]. Toinitially examine the size-fractionated lipid emulsions,phospholipid and triacylglycerol concentrations of eachfraction ... concentrationmultiplied by the ratio of free to bound peptide, a linear plotresults (Fig. 5, inset), yielding an apparent dissociationconstant, Kd ,of7 5lM and binding capacity, Bmax ,of approximately four amino...
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Báo cáo Y học: The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells potx
... concentration of RNA was determined by spectrophotometry at 260 nm, and its integrity wasassessed by agarose gel electrophoresis. PolyadenylatedRNA was prepared by oligo(dT) affinity chromatographyusing ... 5¢-TGTCCAAGGGTGTACATATCAACAT-3¢ (Mer,sense )and5 ¢-AGCCGAGGATGATGAACATAGAGT-3¢ (Mer,antisense),which generated a 700-bp Mer PCR product; 5¢-CGGCATTCCCTTCAAGGAGAGT-3¢ (Gas6,sense )and 5¢-CTCAACTGCCAGGACCACCAACT-3¢ ... incubation on ice for 30 min.The reactions were separated by polyacrylamide gel elec-trophoresis (6%), and analysed by autoradiography.Site-directed mutation analysisSite-directed mutagenesis was...
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Báo cáo Y học: Changes in ultrastructure and the occurrence of permeability transition in mitochondria during rat liver regeneration ppt
... Italy;2Department of Zoology, Laboratory of Histology and Comparative Anatomy, University of Bari, Italy;3Center for the Study of Mitochondria and Energy Metabolism (CNR) Bari, ItalyMitochondrial ... 5443316,E-mail: csmmmg14@area.area.ba.cnr.itAbbreviations: AAT, aspartate aminotransferase; CsA, cyclosporin -A; GDH, glutamate dehydrogenase; PH, partial hepatectomy; EU,enzyme units.Enzymes: aspartate ... mitochondria. Sham-operated rats, obtainedafter a small midline abdominal incision without excision of the liver, were used as a control and killed at 0, 24 and 96 hafter the surgical operation. In all...
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