Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) potx
Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) potx
... (Eur. J. Biochem. 269) 5087 Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) Anders A. Jensen1*, ... agonist-induced intermolecular movements in the CaR homodimer using the new bioluminescence resonance energy transfer technique, BRET2, which is based on the transference of energy from Renilla ... Agonist-induced rearrangement of the 7TMs in the CaR homodimer? One of the goals of the present study was to investigate,whether the activating twist in the ATD dimer of the familyC GPCR homodimer...
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Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
... control of the disease.BackgroundJoint pain accompanied with swelling is a common com-plaint seen in clinical practice. The challenge is to deter-mine the underlying etiology and to provide the appropriate ... in any joint including the ankle, knee, hand, wrist, elbow,sacroiliac joint and other joints of the spine, howevermost commonly occurs in the lower extremity. In thiscase, although the patient ... although these changes are not seen asfrequently as they have been in the past due to better con-trol of the disease.Competing interests The author(s) declare that they have no competing inter-ests.Authors'...
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Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx
... previously [20]. The serine, threonine and tyrosinecontents of the hydrolysates were corrected for destructionduring the hydrolysis by extrapolation to zero time hydro-lysis. The amino acid ... revealed the predominance of two amino acids: alanine (39.2%) andglycine (30%). Interestingly, the proportions are very similarto those found in WSM for alanine and glycine.Curiously, the presence ... glutamic acid-rich in WSM.Glycosaminoglycan analysisGlycosaminoglycans are highly negatively charged becauseof the presence of sulfate ester and/or carboxyl groups.Therefore, they interact with...
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Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... activate the single-strand break DNA repair pathway if applied to host cell DNA. This pathway was investigated by studying the activity of Poly(ADP-ribose)Polymerase (PARP), the protein which ... hepatocytes. We hypothesized that the cyto-toxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA-nicking and DNA-attaching activities of NS1. Upon testing this hypothesis, ... and ATR, (34, 35). The involvement of the DNA damage repair pathway in NS1-induced apoptosis was examined in GFP/NS1-transfected cells by treat-ing the cells with caffeine. Incubation of GFP/NS1-transfected...
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Báo cáo y học: "Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus"
... of the primary or the secondary antibody or primary incubation in the presence of non-immunized rabbit serum instead of the primary antibody. Cell quantification and Statistical analysis The ... quantitatively analyzed. Epithelial cells were considered to be positive if there was any staining of the nucleus, regardless of staining intensity. Cell counting was performed in six high-power ... recombination [13]. MMR genes, including hMSH2, hMLH1, hMSH3, hMPS1, hPMS2 and GTBP/hMSH6 are very important in distinguishing and repairing misparing and slippage errors in DNA synthesis. The...
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Báo cáo y học: "Pre-hospital intubation by anaesthesiologists in patients with severe trauma: an audit of a Norwegian helicopter emergency medical service"
... tothese guidelines during the study period. There was nospecific difficult airway algorithm in the service in the period other than the one available in the anaesthesiol-ogy department under which ... The data included the type of airway device and drugs used tofacilitate ETI, complications and the use of monitoring,including capnography. We anonymised the involvedHEMS physicians and recorded them ... more likely to survive thanthose intubated pre-hospital. Although this difference in injury severity may explain our findings, we believe thatfurther studies are needed to clarify the clinical...
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Báo cáo y học: "Use of chinese and western over-the-counter medications in Hong Kong"
... point of contact when they hadminor aliments. Therefore, there is a need in promotingand extending the roles of the western medicine com-munity pharmacists in Hong Kong.A systematic review shows ... likely to consume Chinese herbal medicines [25].Chinese medicine retailers are therefore instrumental in preventing undesirable drug interactions during prescrip-tion process. In addition, their ... already indicated the needs for western pharmacists to study Chinesemedicine [24].A total of 26.2% of the respondents reported consum-ing Chinese OTC medication in the previous year. The majority...
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Báo cáo y học: " Introduction of Medical Emergency Teams in Australia and New Zealand: a multi-centre study"
... to be undertaken using the information contained within the database.Assessment on timing of introduction of MET serviceWe obtained information from a database maintained by the ANZICS ARCCCR ... (MET) system.• The introduction of such systems in ANZ occurred mostly before any publications reporting the possible effectiveness of such systems.• The introduction of MET systems in ANZ ... was available, the incidence of CAs waslower in the year after the introduction of the MET service com-pared with the year before its introduction. No changes wereseen in other outcome measures....
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Báo cáo y học: "Utility of routine chest radiographs in a medical–surgical intensive care unit: a quality assurance survey"
... sheet documenting the patient’sICU admission diagnosis, the indication for the CXR, and anyresulting changes in management. The ICU team, consisting of the attending physician, a clinicalfellow, ... new findings;however, only 1.4% of these required immediate action [6].Our study evaluated the impact of routine CXRs withouthaving recorded the information yielded by the bedside physi-cal ... of information from the clinicalexamination reduces the utility of routine CXRs, with only3.4% leading to a change in management. The majority of the changes (78%) were related to repositioning...
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Báo cáo y học: "2009 H1N1 Influenza and Experience in Three Critical Care Unit"
... infection in inva-sive and noninvasive mechanically ventilated pa-tients. The body-mass index (BMI, weight in kilo-grams divided by the square of the height in meters) was calculated. Obesity defined ... clar-ithromycin (in 13 patients), piperacillin-tazobactam (in 12 patients), imipenem (in 11 patients), third gen-eration cephalosporin (in 9 patients), vancomycin (in 2 patients), teicoplanin (in ... Laboratory findings of the patients with Influenza A (H1N1) virus in critical care unit Variable Value (mean±SD) Laboratory findings Leukocyte count, per mm3 8.73±6.95 Lymphocyte count,...
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