... PR with the V32I mutation; PRI50V, PR with the I50V mutation; PRI54M, PR with the I54M mutation; PRI54V, PR with the I54V mutation; PRI84V, PR with the I84V mutation; PRL90M, PR with ... compared with PRWT–SQV. (B) PRI50V–APV compared with PRI50V–SQV. (C)PRI54M–APV compared with PRI54M–SQV. (D) PRI54V–APV compared with PRI54V–SQV. (E) PRI84V–APV compared with PRI84V–SQV. ... contacts with APV,the PRV32I–APV complex showed increased hydrophobic contacts withinthe hydrophobic cluster and the PRI50Vcomplex had weaker polar andhydrophobic interactions with APV....