Báo cáo khoa học: Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters ppt
Báo cáo khoa học: Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters ppt
... that the drinking of green tea will have a prophylactic effect on cartilageFig. 4. Inhibition of rhADAMTS-1, -4 and -5 by catechins and gallates.rhADAMTS-1 (A), -4 (B), and -5 (C) were assayed ... activity of ADAMTS-1, -4 and -5. The catechin gallate esters EGCG and ECG potently inhibited ADAMTS-1, -4 and -5 in a dose-dependent manner over a 2 nMto 2 lMconcentration range, whereas catechins ... 185Fig. 1. SDS PAGE and Western blots of partially purified rhADAMTS-1, -4 and -5. Panels A, B and C represent preparations of rhADAMTS-1, -4 and -5, respectively. Mono-Q peaks of aggrecanase activity...
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Tài liệu Báo cáo khoa học: Differential effects of Mxi1-SRa and Mxi1-SRb in Myc antagonism ppt
... differentiation, and so on. Isoforms of numerousproteins have been studied and compared in this man-ner, including alternative isoforms of members of thep53 ⁄ p63 ⁄ p73 [23] and the Bcl2 families ... versions of these twoisoforms, as well as of the Mxi1-WR isoform that lacksthe SID, and shown to give rise to proteins of theexpected size expressed at similar levels (Fig. 1A). Each of these ... stability, and Myc bio-logical activity. Normal regulation of Myc activityoccurs by mechanisms that influence the Myc proteinper se [7], and also through the functions of relatedmembers of the...
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Báo cáo khoa học: Differential binding of human immunoagents and Herceptin to the ErbB2 receptor ppt
... as expected.Analysis by ELISA of the interactions of EDIAs and Herceptin with soluble ErbB2-ECDELISA sandwich assays were performed to determinethe ability of Erbicin and EDIAs to recognize ... competitionin the case of ERB-hcAb.Effects of soluble ErbB2-ECD on the cytotoxicity of ERB-hcAb and HerceptinOn the basis of the results discussed above, theantitumour effects of ERB-hcAb and Herceptin ... constant flow rate of 30 lLÆmin)1, and asso-ciation and dissociation phases were recorded for 200 and 300–600 s, respectively. The sensor surface was regenerated by 30 s injections of 10 mm glycine–HCl,...
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Báo cáo khoa học: "SELECTIVE PLANNING OF INTERFACE EVALUATION" pdf
... precepting. However, neatly all of them are like obsorvem of the recent space shuttle: They can understand liftoff, landing and some of the discus=dons of the heat of re(retry, but the critical ... threat of an evaluation, and they are like the threat of a military inspection. All of the valuable effects are complete before the ins~oection takes piece. Of course, in s mature and stable ... trials are an instrumented variant of normal uSage. The character of the users, their tasks, the data, and so forth are reDreeentative of the intended use of the system. In thinking about evaluations...
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Báo cáo khoa học: Selective detection of superoxide anion radicals generated from macrophages by using a novel fluorescent probe pdf
... Tang, College of Chemistry, ChemicalEngineering and Materials Science,Engineering Research Center of Pesticide and Medicine Intermediate CleanProduction, Ministry of Education, ShandongNormal ... DBZTC2-chloro-1-formyl-3-hydroxymethylenecyclohexene [21]A solution of 40.0 mL of dimethylformamide in 40.0 mL of methylene chloride was chilled in an ice bath. A solution of 37.0 mL of phosphorus oxychloride in 35.0 mL of methy-lene chloride ... 20.47.DBZTCWe added 2.50 g (0.02 mmol) of o-aminobenzenothiol,1.73 g (0.01 mmol) of 2-chloro-1-formyl-3-hydroxymethyl-enecyclohexene and 50.0 mL of a mixture of 1-butanol and benzene (7 : 3 v ⁄ v) to...
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Báo cáo khoa học: Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation pdf
... cleavages and loss of functional activityduring inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 270 , 21158–21166.Interaction of protein C with EPCR and phospholipids ... Cthrough the selective inactivation of activated Factor V.Biochim Biophys Acta 571, 333–342.10 Kalafatis M, Rand MD & Mann KG (1994) Themechanism of inactivation of human factor V and human ... Activatedprotein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J BiolChem 266, 20139–20145.8...
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Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf
... the inhibition of Ras processing caused by HR12 was reversible, and relief of this inhibition correlated with the return of pRb phosphorylation.HR12 leads to an increase in p27Kip1levels and ... examined,Fig. 1. Inhibition of anchorage independent and dependent growth of Rat1/ras cells by HR12. (A) Rat1/ras cells were grown in a layer of 0.3% soft agar in a 96-well plate, and exposed to ... up-regulation of p27Kip1 and hypophosphorylation of pRb.2768 H. Reuveni et al. (Eur. J. Biochem. 270) Ó FEBS 2003inactivation of cyclinE/cdk2, dephosphorylation of pRb, and G1 arrest of Rat1/ras...
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Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx
... activity100200300pIFN-β(-125)-Luc3-4A3-4AMyc-CardifNS(Strain)A(1B-1)(O)3-4AS1165A3-4AW1528ABMyc-CardifdimermonomerAnti-EGFP(Strain)NS3-4A3-4A(1B-1)(O)3-4AS1165A3-4AW1528AIRF-3CMyc-CardifC508A(1B-1)3-4AS1165A3-4AW1528A3-4AMyc-CardifNS3b-actin75kDa5037100(Strain)NS3-4A3-4A3-4A3-4A(1B-1)(O)Myc-Cardif(1B-1)(O)Fig. ... phosphorylation atSer386 and Ser396 of IRF-3, and formed the dimeriza-tion of IRF-3 (Fig. 5A,B, lanes 1 and 2), and thatNS3-4A remarkably inhibited the phosphorylation and dimerization of IRF-3 in the ... level of IFN-β mRNA (%)80100120140+++ 3-4A(1B-1)3-4AS1165A3-4AW1528A+-NS(Strain)C020406080100120Relative level of IFN-β mRNA (%)T-pIC+++ 3-4A(1B-1)3-4AS1165A3-4AW1528A+-NS(Strain)Fig....
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... activity and mitochondrial CYP2E1 exhibitshigh NDMA-d activity. The activities of both micro-somal and mitochondrial enzymes were dependent onaddition of NADPH and inhibited by SKF-525.In ... NADPH, and 4 mm NDMA in a 1.0 mL finalvolume. The reaction mixture was incubated at 37 °C for30 min, and the reaction was stopped by the addition of 0.1 mL of 25% zinc sulfate and 0.1 mL of saturated ... reaction was initiated by theaddition of 3 mm NADPH, and continued for 30 min at37 °C in a shaking water bath. The reaction was terminated by the addition of 250 lL of ice-cold 10% trichloroaceticacid....
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Tài liệu Báo cáo khoa học: Identification of b-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay docx
... collected and suspen-ded in 25 mL of 40% potassium hydroxide and 25 mL of methanol and refluxed for 2 h. Products were extractedwith 50 mL of hexane. The hexane layer was washed with25 mL of saturated ... December2005)doi:10.1111/j.174 2-46 58.2006.05120.xTriterpenes exhibit a wide range of structural diversity produced by asequence of biosynthetic reactions. Cyclization of oxidosqualene is the ini-tial origin of structural ... understanding of the biosynthesis of triterpenesaponins is required, including the enzymes catalyzingthe sequence of reactions and the genes encoding theseenzymes.The biosynthesis of triterpene...
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