... initially identified asan Abl SH3 domain-binding protein of unknown func-tion [25]. Recently, 3BP2 has been shown to interactwith the Syk and ZAP70 proteins of the Syk family of tyrosine kinases. ... activation [35]. In RBL-2H3 mast cells, phosphorylation of Tyr448 of 3BP2creates a binding site for the SH2 domain of Lyn, aSrc family protein tyrosine kinase, and interaction of Lyn with 3BP2 ... resulting in the recruitment and activation of the ZAP70 and Syk PTKs [2,3]. Theseactivated PTKs further induce the tyrosine phosphory-lation of multiple intracellular proteins, including the adapter...