Báo cáo khoa học: Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence pptx
Tài liệu Báo cáo khoa học: Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding pptx
... in vitro refolding pathway of PIP and HPI. (A) Amino acid sequences of PIP and HPI. Amino acids areshown in the one-letter code. The numbering of the residues in HPI and PIP are based on each ... nativePAGE.Isolation and purification of the scrambled disulfideisomers of HPIIn the presence of denaturant and thiol catalyst asindicated above, HPI was converted into the mixture of native and scrambled ... concentration of denaturant.Fig. 3. Unfolding of HPI in the presence of denaturant and thiol cata-lyst. Controls for the disulfide scrambling method include the lack of thiol catalyst and lack of denaturant...
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Tài liệu Báo cáo khoa học: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain ppt
... Involvement of acetaldehyde inalcohol addiction. Alcohol Clin. Exp. Res. 26, 114–119.30. Johansson, B. (1992) A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. ... genes ADH1, ADH3 and ADH4.Similar mRNA length and high nucleotide and aminoacid sequence identity of all ADHs lead to a large risk forcross-reactivity of probes at the mRNA and protein level,making ... cells and Purkinje cells, in the hippocampal formation and differentregions of the cerebral cortex. ADH4 mRNA expressionwas found in Purkinje cells and white matter of thecerebellum, and in...
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Báo cáo khoa học: Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells Soumen Bera1, Theo Wallimann2, Subhankar Ray1 and Manju Ray1 potx
... prominent up-regulation of the expression and enzymatic activity of both AGAT and GAMT. The specific activity of AGAT in sarcomatissue reached almost 50% of that observed in thekidney and it was also ... promoteornithine and SAH production, which in turn could beused for the formation of polyamines and methionine.An investigation of the level of different intermediatemetabolites and the expression of different ... samples and also in theliver, but remained undetectable with this method innormal muscle.RT-PCR and mRNA expression analysis of AGAT and GAMTBoth measurements of catalytic activity and immuno-blot...
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Báo cáo khoa học: Isoquinoline-1,3,4-trione and its derivatives attenuate b-amyloid-induced apoptosis of neuronal cells pdf
... [21–24]. Isatin sulfonamide and its ana-logues are potent and selective inhibitors of apoptosis of chondrocytes and mouse bone marrow neutrophilsin cell-based models of osteoarthritis [25]. M-791 ... isoquinoline-1,3,4-trione and its derivatives protected the growth of axons and dendrites of neurons treated with Ab(25–35) and attenu-ated neuronal apoptosis. Moreover, the protectionafforded by the derivatives of ... indicative of an apoptosis ratio of 4.73%. As the duration of treatment increased to 48 and 72 h, the ratio increased to 19.91% and 31.71%.In contrast, apoptosis ratios were 4.01% and 4.09%when...
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Báo cáo khoa học: Effect of priming on activation and localization of phospholipase D-1 in human neutrophils potx
... subcellular distribution of PLD and the conse-quences of priming and activation were determined usingimmunoprecipitation and Western blot analysis of neutro-phil cytosol and membrane fractions ... burst. However, the repertoire of PLD isoforms present in these primary cells, the precisemechanism of activation, and the impact of cell priming onPLD activity and localization remain poorly ... nature of the PLD isoforms expressed inneutrophils [9,10] and the cosignals required for PLDactivity, in particular the role of phosphatidylinositol3-kinase (PI3-kinase), which we and others...
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Báo cáo khoa học: Adaptation of intronic homing endonuclease for successful horizontal transmission pptx
... published recognition properties of I-SpomI, I-ScaI, and I-SceII were reconsidered from this point of view, and we detected proficient adaptation of I-SpomI, I-ScaI, and I-SceII fortarget site sequence ... occursfive nt downstream of the intron insertion site on thecoding strand and one nt downstream of the insertionsite on the noncoding strand, creating 3¢ overhangs of four nt (Fig. 3). This ... cleavage points of coding and noncoding strands. A summary of substrate cleavabil-ity is classified into four groups (+++, ++, +, and –; see Experimental procedures for details) and shownin Fig....
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Tài liệu Báo cáo khoa học: DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling pptx
... regulation of growth and differentiation in eukaryotic cells [1,82].Despite profound improvements in our understanding of the molecular and cellular mechanisms of action of the Ras proteins, the expanding ... demethylation and hypermethylation.AcknowledgementsThis review is dedicated (by SKP) to Dr MK Pal,retired professor of biochemistry, University of Kaly-ani and Dr D Chattopadhyay, professor of biochemis-try, ... loss of MGMT expression resultsin G to A transitions of the K-Ras oncogene(the most frequently mutated isoform of Ras), and of p53 [1,5,6,41,99]. MGMT, aDNA repair protein, removes mutagenic and cytotoxic...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... concentrations of stea-rate (18:0), oleate (18:1), or mixtures of the two fatty acids, and the effects oncell proliferation, lipid droplet accumulation and induction of endoplasmicreticulum stress and ... under-stood and need further investigation.A number of recent in vitro and in vivo studies haveshown that different forms of fatty acids exert remark-ably different effects. Exposure of a variety of ... varyingcombinations of saturated (stearate, 18:0) and unsatu-rated (oleate, 18:1 cis) fatty acids for various time peri-ods, and cell proliferation, toxicity, induction of ERstress and apoptosis and lipid...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... action of EPA and DHA (Eur. J. Biochem. 271) 4465Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAsInduction of cyclin D1 is one of the e arliest effects of mitogenic ... contribute to the modu-lation of egr-1 gene expression (Fig. 4B).Effects of n-3 and n-6 PUFAs on the synthesis of caveolin-1 and caveolin-3 and on the location of p42/44 MAPK caveolaeCaveolins ... theproduction of PGE2 [18]. The inhibition of PGE2 releasewas the consequence of a reduction of COX-2 and secretoryPLA2 mRNA expression. Moreover, the IL-1 b-inducedexpression of secreto ry...
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Báo cáo khoa học: Mutants of Saccharomyces cerevisiae deficient in acyl-CoA synthetases secrete fatty acids due to interrupted fatty acid recycling docx
... (square)]. (D) Con-centration of fatty acids in the pools of free fatty acids in the media(diamonds), of free fatty acids in the cells (square) and of esterified fatty acids (triangle). The error ... concomitantdecrease of extracellular fatty acids. Therefore, besidesthe import of exogenous fatty acids, additional release of internal fatty acids had to contribute to the increase of intracellular fatty acids. ... pool of free fatty acids contained 18:2 as well; indicating arelease of formerly lipid bound fatty acids into thispool (Fig. 4B,C). Moreover, the ratio of the sum of allnatural fatty acids of...
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