Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc

... a-actinin, either in direct contact or in a complex including the two proteins. In conclusion, our study proves the interaction between a-actinin and calpain 1 and locates binding motifs withinregions ... to the origin of interactions[9,10,12,27] with the targets, the stability of complexes in the resting stage [3,48] and the activation state [7,33] of the binding calpain. The topology of the interface ... The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton Fabrice Raynaud1, Chantal Bonnal1, Eric Fernandez2, Laure...

Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

... formpart of the copper binding sites in this protein.Although there are four histidines in the C-terminal,another histidine is present at position 18, and given the folded state of the protein it ... performed and no binding was observed. In our hands, as others [54], the most reproducible datawas obtained from injections of the metal into a solution of the protein. Typically an initial injection ... high affinitycopper binding protein, and (b) that amyloid fibrilformation of this protein is diminished in presenceof Cu2+ions. Another interesting finding is thatcopper binding gets less strong...

Báo cáo khoa học: Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue docx

... discarded and the pellet containing the [H3]PAF bound to the denaturated BSA is dissolved in the scintillation cocktail (dioxane-base) and the radioactivitywas determined by liquid scintillation ... entered the analyzer throughan interface plate and a 100-mm oriﬁce, while the declus-tering potential was maintained between 60 and 100 V tocontrol the collisional energy of the ions entering the ... are the same molecule.Moreover, inhibitors of platelet aggregation such asBN-52021, indomethacin and the enzymatic system ofcreatinine phosphate and creatinine phosphate kinaseexerted the...

Báo cáo khoa học: Direct CIII–HﬂB interaction is responsible for the inhibition of the HﬂB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx

... direct interaction with the protease, characterized by a lack of interaction between r32 and CIII (Fig. 4). As for CII, competition between r32 and CIII for binding to HﬂB would also decide the ... effectiveinhibitor. We also found that there is no interaction between CIII and r32. From these results, we suggestthat the inhibition of r32by CIII is due to a directCIII–HﬂB interaction. Results In ... PAGE, in the presence orabsence of 5 mM ATP. Numbers on the top of each lane indicate the time of digestion in min. (Lower) Densitometric scan showing the amount of r32-C-his (1.2 lM) remaining...

Báo cáo khoa học: A modelling approach to quantify dynamic crosstalk between the pheromone and the starvation pathway in baker’s yeast pot

... tM.Asfor tM, the intrinsic signal is faster than the extrinsic signal,however, the timing of the combined signal is between the intrinsic and the extrinsic signal, which results in Si<1.SK< ... tM, and s) are smaller for the extrin-sic stimulus (a) than for the intrinsic stimulus (b). Contraryto Table 3, the response to the combined signal is between the intrinsic and the extrinsic ... signalstogether produce a smaller activation than the extrinsic sig-nal alone. This indicates that the intrinsic signal inhibits the extrinsic signal, i.e., there is a crossinhibition. The largerthe...

Báo cáo khoa học: "A MODEL OF PLAN INFERENCE THAT DISTINGUISHES BETWEEN THE BELIEFS OF ACTORS AND OBSERVERS" pot

... ABSTRACT Existing models of plan inference (PI) in conversation have as- sumed that the agent whose plan is being inferred (the actor) and the agent drawing the inference (the observer) have ... transparent from the query in (11) that Q intends to talk to Kathy, intends to find out how to stand on his head, and intends his doing the latter to play a role in his plan to do the former and that ... accessing the file do not include the person's not being the system manager. This can result in R attributing to Q the explanatory belief in (20) and (21), which, in turn, may result in...

Báo cáo khoa học: Induction of raft-like domains by a myristoylated NAP-22 peptide and its Tyr mutant potx

... DS (1999) Interactions con-trolling the membrane binding of basic protein domains:phenylalanine and the attachment of the myristoylatedalanine-rich C-kinase substrate protein to interfaces.Biochemistry ... are insufﬁcient in the case of the Y11L-NAP-22-peptide to modulate the sequestering of cholesterol. In the case of NAP-22, the combined interactions of the myristoyl group, the Tyr side chain and ... alsomodulate the insertion of the peptide into the bilayer as revealed by1HNOESY MAS ⁄ NMR. The intensity of cross peaks between the aromaticprotons of the Tyr residue and the protons of the lipid indicate...

Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx

... thatbenomyl binds to tubulin at a site that is distinct from the colchicine and vinbastine binding sites in tubulin[10,11]. Although benomyl inhibits mitosis in mamma-lian cells, its antimitotic ... signiﬁcantly decreased the distance between the sister kinetochore pairs in metaphase cells and increased the level of the checkpoint protein BubR1 at the kinetochoreregion, indicating that benomyl ... [17]. Kinetochores that are not attached to the microtubules acquire increased concentration of the motor proteins and the spindle checkpoint proteins[18]. The interaction of kinetochores with the...

Báo cáo khoa học: Eukaryotic class 1 translation termination factor eRF1 ) the NMR structure and dynamics of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysis pptx

... rearrangement of the protein during the docking to the binding site on the ribosome or otherligands. Strikingly, the second most ﬂexible part of the protein (if one does not take into account the N-termi-nal ... binding of the protein to the ribosome. The second, and more plausible, is that the loop is situated at the interface between the M and N domains of eRF1, and this ﬂexibility may beinvolved in ... explainedby their competitive inhibition at the ribosome-bindingsite [32].Together, the M and C domains of human eRF1, in the absence of the N domain, are able to bind to the mammalian ribosome and induce...

Báo cáo khoa học: Roles of 1-Cys peroxiredoxin in haem detoxiﬁcation in the human malaria parasite Plasmodium falciparum potx

... 1785protein bound to the agarose. This binding was con-ﬁrmed by the observation that only a trace of the pro-tein was left in the unbound fraction. Pre-incubation of the recombinant protein with ... observed and the initial GS activitywas maintained (116.5 ± 7.3% of the initial activity). The protective effect was abolished when the recom-binant protein was heat-inactivated by autoclaving,suggesting ... but the bindingwas not affected by preincubation of the protein withFP. These results also indicate that Pf1-Cys-Prx canbind to FP at pH 7.4, which is the pH of the parasitecytosol. The fact...

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