... Biochem 31 8, 212–220.
N. Grandvaux et al. IRF -3- mediated antiviral response involves spermine
FEBS Journal 272 (2005) 31 20 31 31 ª 2005 FEBS 31 31
Regulation of arginase II by interferon regulatory factor ... IRF -3 responsive, including the gene encoding
arginase II (ArgII).
ArgII is the extrahepatic isoform of the arginase
type enzymes, and ArgI i...
... stacking of the two domains in the relevant
variant of the hinged conventional hairpin ribozyme
leading to enrichment of an extended inactive confor-
mation [34 ,35 ]. Because of the single-stranded ... that the sequence
and length of the helix between the two loops contain-
ing the cleavage ⁄ ligation site, as well the size of the
bulge, in uence the ex...
... Ser112, Ser 136 and Ser155 [86].
The dissociation of Bax and Bad from 14 -3- 3 is pro-
moted by JNK via phosphorylation of 14 -3- 3 at
Ser184; this reduces the affinity of 14 -3- 3 for Bax and
Bad and translocation ... and
increases the release of cytochrome c from mitochon-
dria into the cytosol through inactivation with Bcl-xL
and Bcl-2 [69]. Inactivated Bax an...
... [102]. In the olfactory
epithelium of 3 6-week-old mice, the expression profile
of HSF1 remains constant. However, a significant
increase in the DNA-binding activity of HSF1 can be
detected during the ... transition of
HSF1 in the olfactory epithelium warrants further
investigations. In accordance with the fundamental
role of HSF1 in the heat shock response,...
... located
between amino acids 133 – 138 at the exposed part of
the cathepsin B molecule near the occluding loop
(Fig. 2C). The location of the epitope indicates that
the binding of 2A2 mAb might change the conforma-
tion ... decrease in the level
of the cathepsin B ⁄ cystatin C complex, whereas the
level of the complex formed between cathepsin B and
the ant...
... between the dCTP(dUTP)-binding
conformer and the dTTP-binding conformer of dCTP
deaminase. We were not able to identify structural
changes in the main chain of the subunit, or in the
interaction of ... prevented binding of the C-terminal
residues over the active site, or the absence of the
C-terminal residues caused the movement of the lip
(Fig. 1B). I...
... activators of the
p38 and PtdIns 3- kinase pathways including thr ombin,
dexamethasone, angiotensin II and prostaglandins stimulate
the expression of CTGF/CCN2 efficiently [8, 43 45]. The
role of the cytoskeleton ... prompt termination of the pr otein s ynthesis.
These data a dd to the growing body of information
supporting a preponderant role of p38 in the...
... T800 and T m–Tn
binding to actin induces a shortening of filament length and
an increase in myosin sliding velocity, suggesting a strong
synergy between these two actin binding components in
their ... properties, and i t interacts with
several protein partners such as myosin, a ctin, M protein,
C protein, MURF-1, calpain 3, myomesin, a-actinin,
nebulin, telethonin and obscu rin....
... modelled in blue in
Fig. 5 according to the X-ray structure of the LHCII
protein [30 ]. In order to further test the hypothesis that
phospho-CP29 plays a role in the binding of phospho-
LHCII to ... Positions of
the peptides in the sequence of the mature CP29 are indicated by
corresponding amino acid numbers. The sequences of the peptides
1–4 were obtai...
... p38 and the
inhibition of Rho proteins, by the use of C3 toxin, inhibits
this response selectively [56]. Additionally, the ability of
constitutively active forms of the upstream activators of
p38, ... unrelated to the JNK pathways and are likely
the result of partial inhibition of the p38 pathway by this
inhibitor as reported previously [32 ].
Interesting...