Báo cáo khoa học: Oligosaccharide synthesis in Fibrobacter succinogenes S85 and its modulation by the substrate potx

Tài liệu Báo cáo khoa học: "Uncertainty Reduction in Collaborative Bootstrapping: Measure and Algorithm" ppt

... view independ-ence. The joining was performed under the condi-tion that the words in the two newsgroups in the first column came from one vocabulary, while the words in the newsgroups in the ... bilingual bootstrapping. In this paper, we propose the use of uncertainty reduction in the study of collaborative bootstrap-ping (both co-training and bilingual bootstrapping). We point ... consider here the problem of collaborative bootstrapping. It includes co-training (Blum and Mitchell, 1998; Collins and Singer, 1998; Nigam and Ghani, 2000) and bilingual bootstrapping (Li and Li,...

Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx

... hydrophobic interactions in proteins [26]. Removing a methyl group in the proteinhydrophobic core affects protein folding and decreases the protein stability in mutant proteins [27]. In PR,two ... Exploring the changes in PR due tobinding of two different inhibitors will give insight into the mechanisms of resistance and help in the design ofnew inhibitors.ResultsAPV inhibition of PR and ... subunits.Amino acids are labeled in one subunit only.APV is shown in magenta sticks. The aminoacids in the inner hydrophobic cluster areindicated by numbered red spheres, and the amino acids in...

Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx

... FEBS 369Thermal unfolding transition in the absence and in the presence of the different ligands The in uence of ligand binding on the thermal stabilityof C-LytA was studied by monitoring the CD ... sigmoidaltransitions (Fig. 2A), reflecting the presence of high-affinity and low-affinity binding sites in the protein and cooperativity in binding [20]. In contrast to cho-line, the atropine and ipratropium titration ... group brings the C-LytAprotein in close proximity to the resin and promotes the subsequent cooperative binding of the rest of the DEAE molecules in a ‘zipper-like’ fashion. In contrast,binding...

Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... an extracellular ligand-binding domain, atransmembrane domain and an intracellular tyrosinekinase domain. The binding of a ligand to the extracel-lular domain of the EGFR induces receptor dimeriza-tion, ... aredown-regulated by geﬁtinib or erlotinib in intestinalepithelial cells [53]. Furthermore, the expression ofcIAP-1 and of X-linked IAP is reduced by AG1478 in squamous cell carcinoma cell lines NA and Ca9-22[54]. ... counterbalanced by CDK inhibitors, including those of the kinase inhibitorproteins (KIP) family and the INK4 family (Fig. 3). The KIP family consists of p27KIP1, p21WAF1 ⁄ CIP1 and p57KIP2; and the INK4...

Tài liệu Báo cáo khoa học: How disorder inﬂuences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx

... protein involved in the coordination of cell wall synthesis and cell growth [18], the nucleoprotein and phosphoprotein from measles and Sendai viruses[19,20] and the Rhabdoviridae phosphoprotein ... (2008) Mappingalpha-helical induced folding within the intrinsically dis-ordered C-terminal domain of the measles virus nucleo-protein by site-directed spin-labeling EPR spectroscopy.Proteins 73, ... B, Finet S &Longhi S (2005) The intrinsically disordered C-terminaldomain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via twodistinct...

Tài liệu Báo cáo khoa học: a-Defensins increase lung ﬁbroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc

... inhibi-tion of the b-catenin signaling pathway by quercetinprevented increases in lung fibroblast proliferation and collagen synthesis induced by a-defensin-1 and a-de-fensin-2. Furthermore, by using a ... proliferation and collagen synthesis involve the b-catenin signaling pathway.Inhibition of b-catenin signaling pathway usingquercetin blocked the a-defensin-inducedincrease in collagen release ... fibroblasts.Inhibition of the b-catenin signaling pathwayusing quercetin blocked the a-defensin-inducedincrease in lung fibroblast proliferation and collagen synthesis To investigate the role of b-catenin activation...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf

... VEGFexpression and induced angiopoietin-1 (Ang-1), therebypromoting the expression of tight junction proteins and strengthening the bonds between brain endothelial cells[19]. Recent studies indicate ... brain damage, microglia begin tomodify their behavior and acquire an ameboid form.This, in turn, alters their antigen presentation and stimulates the release of cytokines, thereby instigatingsubsequent ... selectins,chemokines and integrins. After docking to the vesselwall, leukocytes extend their processes toward interen-dothelial junctions to search for abluminal chemokinecues. Chemokine–chemokine receptor...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... organs,including the brain, is regulated by the VEGF system in combination with other signaling systems such as the angiopoietin–Tie, ephrin–Eph, Delta–Notch sys-tems, and the Wnt pathway.Furthermore, ... astrocytes, and the tight junctions of vascular endothelial cells (ECs) in the BBB are well organized with claudins and ZO-proteins through a decrease in angiogenesis signaling and an increase in the ... angio-genesis in both embryogenesis and adulthood, and functions by binding with two tyrosine kinase recep-tors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR ⁄ Flk-1),Fig. 1. The VEGF–VEGFR system and the inhibitors...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx

... reinter-preted in the context of angiogenesis in the brain. Is itpossible that some of the acute neurovascular events in the brain after stroke represent an endogenous attempt by the brain ... signaling actions involving the platelet-derived growth factor and low-density lipo-protein receptors [32,33]. These experimental ﬁndingsare now beginning to be supported by clinical data. In acute ... this approach lies in the factthat minocycline can be easily used in humans.Taken together, the accumulating experimental and clinical data suggest that MMPs (and perhaps otherextracellular...

Tài liệu Báo cáo khoa học: Catabolite repression in Escherichia coli – a comparison of modelling approaches docx

... EIIA, B and C domains, with the EIIA and B do-mains being part of the phosphorylation chain and the EIIC domain representing the membrane domain. Asall components of the PTS, depending on their ... modules. The pathways for the individual carbohydrates, including the descriptionof protein synthesis, are connected to the glycolysismodule. The PTS reactions, the synthesis of cAMP and the activation ... and cAMP synthesis; accelerator actuator: comprises the control and synthesis of the PTS mRNA; brake actua-tor: describes the control and synthesis of the PtsGrepressor Mlc. Protein synthesis...

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