Báo cáo khoa học: Escherichia coli cyclopropane fatty acid synthase Mechanistic and site-directed mutagenetic studies potx

... Biochem. 271) Ó FEBS 2004 Escherichia coli cyclopropane fatty acid synthase Mechanistic and site-directed mutagenetic studies Fabienne Courtois, Christine Gue´rard, Xavier Thomas and Olivier PlouxLaboratoire ... UMR7613 CNRS, Universite´Pierre et Marie Curie, Paris, France Escherichia coli fatty acid cyclopropane synthase (CFAS)was overproduced and purified as a His6-tagged protein.This recombinant enzyme ... E.J., Paschal, B.M. & Liu, H W. (2003) Cyclopropane fatty acid synth ase from Es cherichia coli. Enzyme p urification and inhibition by vinylfluorine and epoxide-containing substrate ana-logues....

Báo cáo khóa học: Genetic defects in fatty acid b-oxidation and acyl-CoA dehydrogenases Molecular pathogenesis and genotype–phenotype relationships ppt

... 2004MINIREVIEWGenetic defects in fatty acid b-oxidation and acyl-CoA dehydrogenasesMolecular pathogenesis and genotype–phenotype relationshipsNiels Gregersen1, Peter Bross1 and Brage S. Andresen1,21Research ... heart, liver and/ or theneuromuscular systems.Deﬁciencies in the transporters and enzymes involved inthe oxidation of long-chain fatty acids are generally severe and may cause death and severe ... deletions/insertions, stop-codon introductions and Table 1. Transporter proteins and enzymes involved in the mitochondrial saturated fatty acid oxidation. FATP, fatty acid transport protein; CAT,carnitine...

Báo cáo khoa học: Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer doc

... ubiquitously in abroad range of organisms from Escherichia coli to humans[1–3]. Two cyclophilins, E. coli CyPA and E. coli CyPB,have been identiﬁed [4,5], and at least ﬁve cyclophilins inmammals ... (mutant residue) and Leu165 on theb8 strand, and through Leu8 and Thr10 side chains on theb1 strand. In the crystal of free CyPB, a crystallographictwofold rotation axis is observed, and the symmetry ... loop connecting the b4andb5strands, i.e. L ys68, P ro69, A sn70 and Pro71 in CyPB and Ala63, Thr64, Lys65 and Glu66 in CyPA occupies thebottom left side of the cleft and is close to the peptide-binding...

Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf

... (2002)Endocannabinoids in the immune system and cancer. Pros-taglandins Leukot. Essent. Fatty Acids 66, 319–332.24. Cravatt, B.F. & Lichtman, A.H. (2003) Fatty acid amide hydro-lase: an emerging ... Wan,M.,Cravatt,B.F.,Ring,H.Z.,Zhang,X.&Francke,U.(1998) Conserved chromosomal location and genomic structure ofhuman and mouse fatty- acid amide hydrolase genes and evalua-tion of clasper as a ca ndidate neurological mutation. ... & Finazzi-Agro`, A. (2002) Low fatty acid amide hydrolase and high anandamide levels are associatedwith failure to achieve an ongoing pregnancy after IVF and embryo transfer. Mol. Hum. Reprod....

Báo cáo khoa học: Modeling hydration mechanisms of enzymes in nonpolar and polar organic solvents potx

... areimmiscible with water and that have low polar characteris-tics (hexane, diisopropyl ether, and 3-pentanone), and thosethat have polar properties and are water miscible (ethanol and acetonitrile).System ... hydration studies ondry proteins. There is a striking similarity betweenthe water-adsorption properties of proteins in air and in organic solvents [13]. Early studies of Yang &Rupley [14] and ... Thesesimulation studies and the ones presented in this worktypically involve one suspended isolated single proteinmolecule surrounded by water, ions, and organicN. M. Micaeˆlo and C. M. Soares...

Báo cáo khoa học: "Multilingual Named Entity Recognition using Parallel Data and Metadata from Wikipedia" potx

... Igor Twoodore, and Igore Twoodore.We estimate phonetic similarity between a source and target entity by computing Levenshtein and other distance metrics between the source entity and the closest ... of the English sentence. Different and possibly conflicting NE tags for candidate English and foreign sentence substrings according to theWiki-based taggers and the Stanford tagger are spec-ified ... (sequences of tokens) and best corre-sponding English candidate entities. The candidateEnglish entities are defined by the union of entitiesproposed by the Wiki-based taggers and the Stan-ford...

Báo cáo khoa học: Leishmania donovani phosphofructokinase Gene characterization, biochemical properties and structure-modelling studies doc

... of Escherichia coli PFK (PDB code 4pfk [12]). This wasthe most suitable template, given our interest in bothcatalytic and regulatory sites, among the various availablestructures of E. coli and ... muscleenzyme and the catalytic subunit of S. cerevisiae,andthePPi-depen-dent enzymes of E. histolytica, A. methanolica and P. freundenreichii.Sequences of yeast and human expanding beyond ... phylogenetic studies based onsequences of other glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase and enolase, showed groupingof Kinetoplastida (and/ or the related Euglenoida) and Spirochaetes...

Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf

... MESRfellowship.References1 Magalon A & Mendel RR (2008) Biosynthesis and insertion of the molybdenum cofactor. InEcoSal Escherichia coli and Salmonella: cellular and molecular biology (Bo¨ck A, Curtiss R III, ... NarG(1–15) and (B)NarG(1–28).ABFig. 2. (A) Sequences of NarG(1–15) (left) and NarG(1–28) (right) and sequential assignments. Collected sequential NOEs are classified intothick and thin bars ... fitted with the heterogeneous ligand interactionTable 1. NMR and refinement statistics for NarG(1–15) and NarG(1–28) structures.NarG(1–15) NarG(1–28)NMR distance and dihedral constraintsTotal...

Báo cáo khóa học: Membrane transport of fatty acylcarnitine and free L-carnitine by rat liver microsomes pot

... imper-meable to the Coenzyme A thioesters of long-chain fatty acids, these activated derivatives, which are synthesizedfrom nonesteriﬁed fatty acids by fatty acyl-CoA synthetaseon the cytosolic aspect ... Membrane transport of fatty acylcarnitine and freeL-carnitineby rat liver microsomesJason M. Gooding, Majid Shayeghi and E. David SaggersonDepartment of Biochemistry and Molecular Biology, ... peroxisomes also contain overt and latent carnitine acyltransferase activities [2,3] and express the CAC protein [4], it has been concluded thatactivated fatty acids access the peroxisomal matrix...

Báo cáo khoa học: Cytochrome P450 metabolizing fatty acids in plants: characterization and physiological roles pptx

... in the context of cutin and suberin studies [1,2]. These protective biopolymers aremade mostly of hydroxyfatty acids and a,x-dicarbox-ylic acids esteriﬁed to each other and to glycerol. Thehydroxyl ... Gerhardt B (1992) Fatty acid degradation in plants.Prog Lipid Res 31, 417–446.53 Koiwai A & Matsuzaki T (1988) Hydroxy and normal fatty acid distribution in stigmas of Nicotiana and otherplants. ... insights into the conquest of landby plants. Science 319, 64–69.59 Wanders R, Komen J & Kemp S (2010) Fatty acid omega-oxidation as a rescue pathway for fatty acid oxi-dation desorders in...

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