Báo cáo khoa học: Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p pptx
Báo cáo khoa học: Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics pdf
... of the atoms. The eigenvalues reflect the magnitude of the fluctuationalong the respective EVs. Structural superpositions and other conformational analyses were performed using lsq-man [56] and ... the coordinated loop dimension(EV1) and the His156-out dimension (EV2). The tra-jectory reaches the EV1 value of the open sulfate_1*structure (maximum 1.73) and exceeds the EV2 values of the ... brucei enolase in the presence of FPAH.Fig. S3. Alignment of enolases from human and try-panosomatids.Fig. S4.LIGPLOT [59] figures of the interactions withenzyme of ligands in the new complexes.Fig....
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Báo cáo khoa học: Structural model for an AxxxG-mediated dimer of surfactant-associated protein C pptx
... connectivities between the twosubunits of the putative dimer because of extensive overlapin the homonuclear NMR spectra and to the weakness of the NOE signal for molecules of this size. We have thereforeused ... inspace, and the energy of the system is minimized withrespect to the position and orientation of the other mono-mer, along with selected bond rotations in both monomers(see below). The center of ... restrict the number of variables in the calculation,valines 23, 24 and 27, which point away from the dimerinterface and which shifted little in the results of the initialsearch, were locked into their...
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Báo cáo khoa học: Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p pptx
... assigned their corresponding binding sites and elucidated the importance of ATP-binding and -hydrolysis of Pex1p and Pex6p for their interaction. We show that the interaction of Pex1p and Pex6p ... for the Pex1p Pex6p interaction and their functional role in peroxisome biogenesis.Results The contribution of Pex1p and Pex6p to peroxisomalbiogenesis is well established on the basis of the ... analysis revealed the presence of Pex6p in the precipitate of full-length Pex1p ProtA and also the presence of Pex1p in the full-length Pex6p ProtA-precipitate(Fig. 1C,D). These data confirm the in vivo interaction of...
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Báo cáo khoa học: Structural and functional analysis of ataxin-2 and ataxin-3 potx
... USP7/HAUSP, and the length of the polyQ region influences the strength of the interaction [163]. Unfortunately, the centralpart of the Josephin domain is difficult to model because of low sequence ... the stability of t he dimer. The first c luster includes F70/V336 and I72/Q338 ( both in b5 s trand) of D3 and F 27/Y289(b2 strand), L67/M324, V70/I327 and L72/L328 (all in b4strand) of B. The second ... flexibility of the C-terminal tail of ataxin-3 [72].Furthermore, the ANTH domain itself is evolutionarily,structurally, and functionally related to a VHS domain[101]. Lately, the structure of the...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
... hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remainsunclear and it is uncertain whether it has the capacityto ... II. The hood domain is mainly builtup by residues from the C-terminus and consists of atwo-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig. 1A). The two ... interacts with bothO6 and N7 (Fig. 1C). The 2¢OH of the ribose is hydro-gen bonded to the main chain and the side chain of Asp142 (Fig. 1C). Both hydroxyl groups of the riboseare involved...
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Tài liệu Báo cáo khoa học: Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium ppt
... indicate the starting and ending residues of the secondary structural elements. (C) The domain-swapped dimer of St SurE. The A and B subunits areshown in green and blue, respectively. The darker and ... the majority of the residues. There wereno disordered regions in the map. The quality of refinement of the two crystal forms is shown inTable 1. Cis peptides were found between R81 and P82 and ... as in archaic and thermophilic homo-logues. The St SurE monomer consists of 13 b-strands,six a-helices and three 310-helices. The core of the pro-tein is made up of a nine-stranded b-sheet...
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Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt
... to the side chain of Asp70, and onefrom the backbone N of Gly63, and the phosphategroup forming hydrogen bonds from O1 to Arg55,from O2 to the backbone N and the side chain of Thr138, and ... Thr197 and Glu204(Fig. 3A,C), and a hydrophobic interaction betweenThr131 and Phe133 (Fig. 3D). The central channel of the hexamer is made up of two layers of electrostaticforces on top of each ... A and F, B and D, or C and E.A phosphate ion was found in the donor site of allsubunits (Fig. 2B), although the protein was crystal-lized in the presence of 5 mm GTP. The B factors forthe...
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Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx
... removal of the CUBdomains and thereby activation of the growth factordomains. PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and pro-teolytic cleavage is therefore ... lymphoid cell infiltrates of the lung and fibro-sis in the liver [110].Conclusions The novel members, PDGF-C and -D, of the PDGFsubfamily of the cystine knot family of growth factorsare potent ... a wide scope of biological effects;however further understanding of how these factorsinterplay with other members of the cystine knot family and in particular the PDGF-A, -B, and VEGF growthfactors,...
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Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx
... F, which protrudes from the core of the monomer and runs anti-parallel to the same strand of a second monomer, allowing for the formation of the dimer. The surface of interaction between monomers ... glutamate and aspar-tate residues confined to the portion of the moleculeinvolving a-helix A, the nearby loop, the first and lastturns of helices E and F, and the C-terminus helices I and J. In ... Helices B,E, F and H, arranged in an up -and- down topology,form the structural core, whereas the short helices C,D and G on one side, and A, I and J on the other,represent types of appendices,...
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Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf
... interaction between strands b2 and b6 of neighboring monomers. The p26 modifications examined in this study are notlocated in either of these strands and they are not con-sidered further.As the basic p26 ... result of the residue’s location at the edge of the dimer–dimer interface. The maximum oligomer sizeobtained with p26 R114A was 500 kDa, closer to the mass of the WT oligomer than the other ... tetramers, the next level of struc-ture. Modeling indicates that tetramer formationdepends upon contact of b-strand 10 from the C-ter-minal extensions of monomers A and D withb-strands 4 and 8 in the...
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Từ khóa: báo cáo khoa họcbáo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDENghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ