Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc
Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc
... in modulating the metal release from metallothionein in the absence of nitric oxide by Vallee, Maret and coworkers [22,37,38]. These authorsreported increased metal release in the presence of ... tighter binding of cadmium than zinc in metallothioneinsand the preference of zinc in the more flexible b-domain. In addition to the already described differences in flexibility of the b-domain in MT ... glutathione redox state in vitro because the oxi-dation state of thiols is involved in the metal binding in Cd-Sor Zn-S clusters found in metallothioneins, and NO alsobinds to reduced glutathione...
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Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identification of oscillophores ppt
... cycles in such a combinationdo not touch each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the magnitude of a Ôminus combined autoinfluence ... vicinity of the steady state. We do this to investigate the stability of this state. In this way we obtain the in uence a small change in the concentration of substance j, i.e. Dxj,hasonthetimedisplacement ... negative in the characteristic equation(a positive autoinfluence). The absolute magnitude of acombined autoinfluence path is the product of all the ratesdivided by the product of all the concentrations...
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Tài liệu Báo cáo khoa học: N-Methyl-L-amino acid dehydrogenase from Pseudomonas putida A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily ppt
... meth-ylamine are bound to the enzyme in this order, andN-methyl-l-alanine and then NADP+are released from the enzyme. Therefore, the kinetic mechanism of the enzyme is the same as those of conventional ... assay of fractions from the Blue-Sepharosecolumn revealed that a 36-kDa protein was the enzymeexhibiting the NMAADH activity. The N-terminalamino-acid sequence of this protein was determined ... as components of several depsipeptides, including cyclosporin A [1],vancomycin, destruxins [2], didemnins [3], dolastatin[4], and enniatin [5], as well as a calpain inhibitor from Streptomyces...
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Tài liệu Báo cáo khoa học: Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits ppt
... quantified by phosphorimaging of the band corresponding to the full-length protein, and normalizing to the Coomassie bluestaining of the same band.)It was next demonstrated that the kinase eluted in fraction ... aldosterone and insulin, as well asintracellular signalling components such as protein kinase Cand protein kinase A, were found to increase the in vivophosphorylation of the C termini of both b ... presence of the a subunit of CK2 in the active cytosolic fractions(Fig. 6), and the finding that the electrophoretic mobility of the phosphorylating kinase corresponds to that of the asubunit of CK2...
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Báo cáo khoa học: On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes ppt
... Mutations in the 23S ribosomal RNA in the vicinity of the double hookbinding or in the b-hairpin of protein L22 were shown tobypass the elongation arrest [72]. The swing of protein L22 hairpin tip ... puromycin derivatives in the active site as well as the 3¢ termini of the docked tRNA[1,3,5,6]. The motions of the tRNA molecules originating from this local symmetry explain why the 3¢ ends of the A- ... from the A-site tRNA a-aminogroup to the P-site tRNA leaving group. Release of the P-site tRNA, the leaving group, may be assisted by the flipping of the A-site 3¢ end into the P-site, and by the reorganization...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... present investigation examines the coupling of drug binding toATP hydrolysis. Initial drug binding to the protein requires a high-affinityinteraction with the drug binding site, followed by transition ... 10½ðlogIC50ÀLÞnð1Þwhere B is the maximal [3H]daunomycin binding, Bmaxis the maximal binding, Bminis the minimum binding, IC50is the concentration of drug that leads to half-maximal bind-ing of radiolabel ... ([E]Æ[ADP]Æ[Vi]) remained in a low-affinity[3H]daunomycin binding conformation. By inference,therefore, the step in the catalytic cycle correspondingto the release of inorganic phosphate ([Pi])...
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Báo cáo khoa học: A novel antifungal hevein-type peptide from Triticum kiharae seeds with a unique 10-cysteine motif doc
... location of eightcysteine residues and several other amino acids of the chitin-binding site (Fig. 2). The striking similaritybetween WAMPs and the chitin-binding domains of class I chitinases ... conserved. To the best of ourknowledge, this is the first communication on such areplacement in the chitin-binding site. Analysis of chi-tin-binding properties of WAMPs by in vitro assaysshowed ... com-prise the single hevein domain subfamily in a largegroup of chitin-binding proteins [13–16] that share acommon property, the ability to bind chitin, a beta-1,4-linked polymer of N-acetylglucosamine...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... Nota-bly, in the presence of the neurotoxin, there was adelay in the lag time for fibrillation. The lag timeincreased from 74.9 h in case of a -synuclein alone to86.8 and 93.6 h in the presence of ... 1B shows the patternseen after the development of the blot. With increase in time of incubation, the intensity of the band for the monomeric protein decreased, whereas the bands for the higher ... results obtained when a-synuclein wasincubated in the absence of MPTP. When a-synucleinwas incubated alone in the presence of dopamine, itled to inhibition of fibrillation, probably by the accu-mulation...
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Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx
... significant production of Pi in the vicinity of the ATPase within the matrix.CYPD ablation or its inhibition by cyclosporin Aincreases the rate of respiration stimulated by arsenate in intact mitochondriaRegarding ... andunbinding by cyclosporin A was demonstrated in the present study in intact mitochondria. This is the result of an imposing role of the ANT. Apparently, the ADP–ATP exchange rates by the ANT ... mediated by a relief of inhibition by cyclophilin D was evident in the form of slightly increasedrespiration rates during arsenolysis. However, the modulation of F0F1-ATPsynthase by cyclophilin...
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Tài liệu Báo cáo khoa học: Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae pptx
... morphology of the strains used in this study. (A) Morphology of deletionstrains. The indicated strains were grown in YPD to stationary phase. The cells werethen fixed with formaldehyde and examined by ... vitro activity of acyl-CoA:ergosterol acyltransferase wasdetermined in an are1 deletion background. The enzyme activity in the ste20D strain and the cla4D strainwas indistinguishable from that in the ... The dele-tion of either ERG4 or NCP1 in the cla4D backgroundis lethal, indicating that CLA4 and these genes, encod-ing proteins involved in sterol synthesis, may function in the same pathway(s)...
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