... byenzymes in the new group is also likely to resemble that of the human PpiA and PpiB and most others. In the bindingsite of the B. malayi Ppi,theequivalentofAla118isFig. 4. Sequence alignment. The ... target.Acknowledgements The authors thank Markus Dalin for help with cloning and i nitialcrystallization experiments, Andrea Wilnerz on and Jimmy Lindbe rg for help with cry stall ization, and Jenny Berglund and Annette ... kcat/Km of 2.0 · 106M)1Æs)1 ,and therefore shows s imilar activity to the Ppi from Brugiamalayi,withakcat/Km of 7.9 · 106M)1Æs)1[26], and tohuman PpiA, with a kcat/Km of 1.4...