... (AA) is first convertedinto prostaglandin G2(PGG2, catalytic step 1), and then to prostaglandin endoperoxide [prostaglandin H2(PGH2)] (catalytic step 2) by COX isoform-1 (COX-1)or COX-2 ... downstream synthases, and is isom-erized to prostaglandin D2, prostaglandin E2(PGE2),prostaglandin F2(PGF2), and prostaglandin I2(PGI2)or thromboxane A2(TXA2) by individual synthases(catalytic ... aggregation by up to 50%(Fig. 6B, bar 2).Competitively upregulating PGI2biosynthesis inthe presence of platelets To further demonstrate the competitive upregulation of PGI2biosynthesis by COX-1–10aa–PGIS...