Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc

... 2006 FEBS 3767 Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways Rainer ... 2. Inhibition of proliferation of LXF-289 lung tumor cells.Effects of signaling pathway inhibitors on ATP-inhibited proliferation (A) and of basal proliferation (B) of LXF-289 lung tumor cells. ... respectively. These resultsconﬁrm the identical potency of ATP and ADP in the inhibition of LXF-289 cell proliferation. Cell cycle analysis revealed that inhibition of prolif-eration of LXF-289 cells by...

Báo cáo khoa học: Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis The role of glutathione doc

... middle of the range of the standardcurve (0–0.20 pmol). The amount of GSH was calculated by subtracting twice the amount of GSSG from the total. The protein pellet was resuspended in 1 m NaOH and used ... levels and GCL activity, showing that the exposure time and the level of the mutant protein modulate GSH synthesis. We conclude thatfailure of the regulation of the GSH pathway caused by G93ASOD1 ... transactivator protein tTA and permitting tetracy-cline-regulated gene expression [55]. In our tet-off system,expression of the responsive protein is repressed by the addition of the tetracycline analogue...

Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx

... growth and proliferation, is uncertain. Hence, itis of interest to investigate the uptake and metabolism of NTBI in normal and cancer cells, and the effect of Fechelators on these processes.In the ... 1693Eﬀect of chelators and Fe status on subcellular distribu-tion of NTBI in hepatocytes. The effect of the chelators on the intracellular distribution of Fe in normal and Fe-loadedhepatocytes in the ... chelators on the uptake and fate of NTBI and to investigate the potential of these chelators for therapeutic use in Fe overload diseases and cancer chemotherapy. Desferrioxamine (DFO), the only chelator...

Báo cáo khoa học: Adenine, a hairpin ribozyme cofactor – high-pressure and competition studies potx

... addition of the cofactors adenine and Mg2+. The kinetics of self-cleavage of ADHR1 were analyzed after 10 min of preincu-bation with either adenine (d) or MgCl2(h) before starting the reaction by ... extract the values of the rate constant and of the apparent equilib-rium. However, it is well established that Mg2+induces the docking of loops A and B for the struc-tural organization of the ... isunlikely on the basis of the results presented in the preceding section) or from re-equilibration of the reac-tion on the basis of the DV, the pressure increasing the rate of the ligation reaction....

Báo cáo khoa học: Glucagon-like peptide-2 stimulates the proliferation of cultured rat astrocytes pptx

... of GLP-2 (1 lM) and fetal bovine serum (10%) on the percentage of cells present in each phase of the cell cycle incomparison with the control cells. The decrease in the number of cell in the ... the percentage of hypodiploid cells with respectto total cells [31] and the stage of the cell cycle as the percentage of cells in G0/G1 (diploid cells), G2/M (tetra-ploid cells), and S (intermediate ... [3H]thymidineincorporation in the Caco-2 human epithelial cell line [47].Further information about the effect of GLP-2 onastrocyte proliferation was obtained upon analyzing itsaction on the progression of the cell...

Báo cáo khoa học: RNF13: an emerging RING ﬁnger ubiquitin ligase important in cell proliferation pptx

... hatching). The transcript and protein levels of RNF13 were determined by northern and western analysis, respectively. The ethidium bromide staining of 18S and 28S ribosomal RNAs and immunoblotting of ... between the plasma mem-brane and the inner nuclear membrane [19,20]. There-fore, further investigation of the dynamic regulation of RNF13 sublocalization within cells will shed lighton the functional ... degradation of the tumor suppressor protein p53 by ubiquitination[25,26]. Skp2, another ubiquitin ligase, is also overex-pressed in human cancers and functions as an onco- protein by regulating the...

Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc

... inclusion of these sulfated agents there was signiﬁcant inhibition(40%) of rate of loss of 35S-labeled large proteogly-cans from the matrix by the end of the culture period.Similarly, by day 10 of ... suppressed by the inclusion of the sulfated polysaccharides. At the end of the cultureperiod, both CaPPS and heparin reduced the appear-ance of [35S]sulfate in the culture medium by 5 and 11%, ... responsible for the synthesis and maintenance of the extracellular mat-rix. Type I collagen is the major macromolecule pre-sent in the extracellular matrix of tendon, comprisingover 50% of the dry...

Báo cáo khoa học: Adenine and adenosine salvage pathways in erythrocytes and the role of S-adenosylhomocysteine hydrolase A theoretical study using elementary ﬂux modes Stefan Schuster and Dimitar Kenanov ppt

... in the buildup of ATP from adenosine. Five out of 12modes require ADA, AK and PNPase, and anotherthree require AK and PNPase but not ADA. None of the 12 modes requires ADPRT. The modes of ATP ... interesting to analyse, in the future, which of the salvage pathways are preferably used in vivo and whether they comply with these criteria. This, however,is beyond the scope of the present study, ... is devoted to the study of redundancy and yield of salvage pathways in human erythrocytes. These cells are not able to synthesizeATP de novo. However, the salvage (recycling) of certain nucleosides...

BÀI BÁO CÁO KHOA HỌC TẠI BẮC KINH ATCM 2009 THE SCIENTIFIC REPORT IN BEIJING - CHINA

... second number then we multiply two numbers together•Press the = key. Answer : 2.232710263 We continue to delete the digit 2 at the first number and the digit 7 at the second number then we multiply ... 1 The number contains the end two digits are digit 1 The number contains the end three digits are digit 1 The number contains the end four digits are digit 1Answer : the number contains the ... key and press 1 key6y⇒ =956 =5. Find the fourteenth digit after of the decimal point of We have : the digit 5 can have rounded We try the digit 5 can not have rounded We set : The second...

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... (black) and sucrose (grey). Doc. S1a. Model structure of C24. Doc. S1b. sbml format of model structure of C24. Doc. S2a. Model structure of Rsch. Doc. S2b. sbml format of model structure of Rsch. Doc. ... Krapp A, Hofmann B, Schafer C & Stitt M (1993) Reg-ulation of the expression of rbcs and other photosyn-thetic genes by carbohydrates – a mechanism for the sink regulation of photosynthesis. ... interconversion rates as a function of time of cold exposure, (b) comparison of the magnitudes of the various interconversion rates, and (c) lineup of the accessions with respect to their metabolic acclimationstrategies....

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