... receptor and Grb7. A role for two of its binding domains, PIR and SH2. Oncogene 19, 2052–2059.36 Daly RJ, Sanderson GM, Janes PW & Sutherland RL(1996) Cloning and characterization of GRB14, ... inhibitor of insulin signaling. Consistent with this observation,overexpression of Grb14 in CHO-IR cells impairs Akt and ERK insulin signaling pathways and inhibits distaleffects of insulin ... immunoblots and results of densitometric measurementsexpressed as arbitrary units (AU) for phos-phorylated RCAM-L (p-RCAM-L) and per-centage of control (no KCl treatment) forGrb14, IRb and p-IRb...