Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx

... MINIREVIEW The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease Peter J. Crouch1, Anthony R. White1and Ashley I. Bush2,31 Department of Pathology ... bio-availability have the potential to ameliorate several of the dysfunctional events characteristic of Alzheimer’s disease. Metal- basedtherapeutics have already provided promising results for the ... may therefore repre-sent a potential therapeutic strategy for preventing the tau hyperphosphorylation and NFT formationcharacteristic of AD. Modulation of metal availability for treating AD...

Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the speciﬁcity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf

... substrates. The data for the PA catalysed hydrolysis of PhAc-Asp and PhAc-Glu[13] and our data for PhAc-pAB, PhAc-mAB and PhAc-oAB (Table 2) imply that the COOH group has to be posi-tioned as ... properties. The kinetic para-meters of the PA-catalysed hydrolysis of the studiedphenylacetyl arylamides are compared in Table 2. The substrates are arranged in a decreasing order of the ratio of their ... stabil-ization of the tetrahedral intermediate. Experimental data[21] for the efﬁcient hydrolysis of NIPAB catalysed by the ArgB263Lys mutant PA and the lack of hydrolytic activity for the ArgB263Leu PA...

Báo cáo khoa học: Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis The role of glutathione doc

... comparison post-test was used for statistical analysis.AcknowledgementsWe are grateful to Dr N. Cashman for providing the original NSC-34 cell line and Prof. T. J. Kavanagh for the antibody against ... modulate GSH synthesis. We conclude thatfailure of the regulation of the GSH pathway caused by G93ASOD1 maycontribute to motor neuron vulnerability and we identify this pathway as a target for therapeutic ... 2D,E). There was a sharp contrast in the effect of wild-type and mutant SOD1, with a signiﬁcant increase in the GSH : GSSG ratio inhighG9 3A- tTAcells. This was accompanied by a shiftto a more negative...

Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx

... germ-cell development and germ-cell malignancy.Nature 460, 909–913.89 Hong H, Takahashi K, Ichisaka T, Aoi T, KanagawaO, Nakagawa M, Okita K & Yamanaka S (2009)Suppression of induced pluripotent ... carrying the human mutant variant of the b-globin gene (bS)that is responsible for the disease. Fibroblasts from a diseased animal were reprogrammed into iPSCs, and the sickle cell anemia was corrected ... disease, as well as the overall lack of donors, impair use of these celltypes for therapy. For these reasons, in vitro production of hESC-derived HSCs represents a remarkable oppor-tunity for...

Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx

... number of these neurons arescattered in the pontine raphe nucleus, the periaqu-eductal gray matter, and the area dorsal to the substantia nigra in the midbrain reticular formation.By immunostaining ... area (LH) and intergeniculate leaﬂet of the thalamus (Fig. 1B). Ultrastructural examinationrevealed that relaxin-3 was localized to the dense-corevesicles in the perikarya, and it was also observed ... may form a midline behavior controlnetwork, and many targets of the NI, such as the med-ial septum, hippocampus, hypothalamus, mammillarycomplex and amygdala, are involved in arousal mecha-nisms,...

Tài liệu Báo cáo khoa học: Bacterial-induced hepoxilin A3 secretion as a pro-inﬂammatory mediator pptx

... responsible for the membrane release of arachidonic acid (AA), the precursor of HXA3. Once liberated within the cytosol, AA is available as a substrate for 12-lipoxygenase (12-LOX), the enzyme ... significance,signaling pathways leading to HXA3secretion mayprovide an important new therapeutic target for the treatment of acute and chronic diseases of intestinal,lung and perhaps other mucosal surfaces.AcknowledgementsI ... because 12-LOX activity is induced at active sites of this disease. Because HXA3may play an important step underly-ing the pathophysiology of inflammatory diseases, such as inflammatory bowel disease, ...

Tài liệu Báo cáo khoa học: "Phrase-Based Statistical Machine Translation as a Traveling Salesman Problem" docx

... suboptimalchoice for phrase-based decoding, and we willpropose an alternative. This alternative is based on the observation that phrase-based decoding can bevery naturally cast as a Traveling Salesman ... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 333–341,Suntec, Singapore, 2-7 August 2009.c2009 ACL and AFNLPPhrase-Based Statistical Machine Translation as ... heuristic333estimate of the remaining cost for completing the translation. The variant which is mostly used is a form of beam-search, where several partial can-didates are maintained in parallel, and candidatesfor...

Báo cáo khoa học: Deﬁciency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice pot

... plasma FFAs are pivotal for the accumu-lation of triglycerides in the liver of experimental mice[29,30], and that enhanced plasma lipoprotein lipaseactivity promotes the deposition of plasma ... heavy loading with fat. The reticulin stain is a classical histopathological mar-ker for the identiﬁcation of hepatic architecture andstructural damage within the liver parenchyma. There-fore, ... micerevealed increased levels of steatosis, as demonstratedby the existence of a large number of lipid dropletswithin the vast majority of the examined hepatocytes.Steatosis was diffuse and of the...

Báo cáo khoa học: RIP1 comes back to life as a cell death regulator in TNFR1 signaling docx

... in the plasma mem-brane early after receptor ligation whereas the celldeath regulators FAS-associated via death domain(FADD) and caspase 8 are recruited to a pro-apopto-tic complex that forms ... T, Tada K, Sakon-Komazawa S,Katano M, Tanaka M, Yagita H, Okumura K,Tominaga N, Hayashizaki Y et al. (2004) Genome wideanalysis of TNF-inducible genes reveals that antioxidantenzymes are ... ligase domain of A2 0 attaches degra-dative ubiquitin chains to RIP1, which targets RIP1 to the proteasome. The deubiquitinase and E3 ligaseactivity of A2 0 are required for A2 0 to block activa-tion...

Báo cáo khoa học: An antimicrobial peptide tachyplesin acts as a secondary secretagogue and ampliﬁes lipopolysaccharide-induced hemocyte exocytosis potx

... exocytosis of granular hemocytes of the horseshoe crab [17]. Mastoparan was ﬁrst identi-ﬁed as a stimulator that led to the release of histaminefrom rat mast cells [33]. Mastoparan forms an amphi-philic ... horse-shoe crab antimicrobial peptides. J Biol Chem 276,27166–27170.26 Kawabata S, Nagayama R, Hirata M, Shigenaga T,Agarwala KL, Saito T, Cho J, Nakajima H, Takagi T& Iwanaga S (1996) Tachycitin, ... determinedby surface plasmon resonance analysis (Fig. 5A, B). The passage of mastoparan at various concentrationsover G protein immobilized on a sensor chip yieldedan association rate constant k a ¼ 2.0...

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