... their binding to and activa-tion of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, ahallmark of the Gas6–Axl system is the unique ability of Gas6 and pro-tein S to tether their ... itselfagainst and interact with the membrane, thus enabling the SHBG domain to bind to the receptor on either the same or another cell.Axl, Sky and Mer in cancer The transforming activity of Axl ... animal models of kidney disease[31]. Significantly, warfarin administration at subclini-cal doses inhibits these increases, further supporting the involvement of vitamin K (and Gas6) in the dis-ease...