Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
Báo cáo khoa học: Nck-1 selectively modulates eIF2aSer51 phosphorylation by a subset of eIF2a-kinases docx
... RL & London IM (1984) The regulation of initia-tion of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2. J Biol Chem 259, ... 2007)doi:10.1111/j.1742-4658.2007.06110.x Phosphorylation of the a-subunit of the eukaryotic initiation factor 2(eIF2) on Ser51 is an early event associated with the down -regulation of protein synthesis at the level of translation and ... into the modulation and complexity of the phosphorylation of eIF2a on Ser51 under variousstress conditions. The involvement of the adaptor protein Nck in this process further highlights the ver-satile...
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... cases. The order of phos-phate processing and the characteristics of protein protein interactions turn out to be of overriding importance for both sensitivity and speed of response. Random phosphate ... thermodynamic aspects of complex multisite phosphorylation on the one hand, and the specific and versatile regulation of protein activation required in signaling pathways on the other.ResultsMathematical ... shape of the response curve isstrongly affected by the two groups of parameters thatdetermine the protein protein interactions: the concen-trations of the enzymes relative to the target protein, and...
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Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx
... composed of a hOrn and a haOrn moiety.Furthermore, a long-range1H–13C correlation wasdetected between the carbonyl carbon of the serine and the d-CH2 of the hOrn, which constitutes the DKP.Therefore, ... characterization of these compounds isgrowing and may result in the synthesis of specificinhibitors based on the structure of the pathogensiderophore [16].A promising approach for the isolation of secondarymetabolites, ... S3–7. The observed NOE contacts and the long-range1H-13C correlations verified the structure and are listed in listed in Tables S5 and S6. On the basis of the results obtained by NMR, the determinedsequence...
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Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx
... MS data on the components of all HPLC fractions indicate the presence of a variety of lipid, sugar and phosphate Fig. 1. The young of Macropus eugenii (A)climbing into the pouch and (B) attached ... (i.e. when the young has no immune system of its own), whenthere is a profound fall in the microbial flora of the pouch [6]. Neither eugenin nor other low molecularmass components of the pouch ... asstimulation of the proliferation of lymphocytes, activa-tion of CCK receptors stimulate production of inter-leukins and secretion of immunoglobulins on the mucosal surface of the intestine [49,50]. The...
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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc
... show that the data fit well with the indi-vidual determination of flux control coefficients by PFK, PK and LDH. The role of the las operon is dis-cussed on the basis of the distribution of flux controlfor ... the activity of the PTS system and therebyresult in further increases in hexose phosphate pools. The decreased LDH activity may contribute further tothis effect by causing an accumulation of ... individually and simultaneous by changing the expression of the respective genes. We found that nei-ther the individual enzymes nor the sum of the lasenzymes had significant control on the glycolytic...
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Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt
... preparation. Of particular importance is the finding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38.In other words, the presence of CD38 is mandatoryfor the ... nucleotides and nucleosides plus products of the degradation of the exogenous cADPR, and therefore were not analyzed indetail. The enhancing effect of cADPR on ATP overflowwas not reduced by the nonselective ... solution in the absence and presence of tissue were detected by RP-HPLCtechniques in conjunction with fluorescence detection [51]. The increase in the amount of the product cGDPR in the presence of tissue...
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Báo cáo khoa học: Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase doc
... important portion of the fusion protein wasdegraded by the host proteases. On the other hand,attempts to produce a His-tagged version of the Rv1771 protein by using the pRSETc or the GatewaypDEST17 ... confirmed by enterokinasetreatment. After digestion of the affinity-purified GST-tagged protein with enterokinase followed by concen-tration, the 70 kDa band disappeared, and two newbands of 45 and ... oxidoreductases.In order to determine the enzymatic activity of the GST-tagged Rv1771 protein of M. tuberculosis, the oxidase activity was tested in the presence of the l-gul-ono-1,4-lactone and l-galactono-1,4-lactone...
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Báo cáo khoa học: Novel c-carboxyglutamic acid-containing peptides from the venom of Conus textile docx
... Gla(3)–TxVI:confirmation of the presence of BrTrp. Product ionmass spectrum of the doubly charged ion at m ⁄ z ¼660.18. The isotopic distribution of the b2ion (inset)indicates the presence of bromine. The MS ... to the N-terminal signal peptide [7,14–17]. The propeptide mediates binding of the substrateto the carboxylase and also activates the enzyme. The discovery of c-carboxylated conotoxins and, more ... Gla(1)–TxVI.Kinetic studies utilizing the Conus c-carboxylase and synthetic peptide sub-strates localized the c-CRS of Gla(1)–TxVI to the region )14 to )1 of the polypeptide precursor: the Kmwas reduced from...
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Báo cáo khoa học: Examining multiprotein signaling complexes from all angles The use of complementary techniques to characterize complex formation at the adapter protein, linker for activation of T cells pdf
... high-resolution images of protein localization and protein protein interactions [55]Isothermal titration calorimetry Measure thermodynamic constants, affinity and stoichiometry of a protein protein interaction[28]Analytical ... methods. These approachesoffer the opportunity to probe the basic mechanism of protein protein interactions in great detail. First, the affinity of the LAT-binding proteins, PLC-c1, Grb2 and Gads, ... composition and stoichiometry of these signaling complexes? Whatis the molecular mechanism for the induction of thesecomplexes? How does the formation of signaling com-plexes lead to the activation of...
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Báo cáo khoa học: Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential doc
... Effects of different concentrations of CsA and its analogson the Ca2+-dependent induction of opening of the MPTP. The dataare representative of four experiments. A concentration of 1 mMCa2+was ... from the mito-chondrial matrix towards the inner membrane space,thereby creating a proton gradient. The energy storedin the proton gradient is used to drive the process of oxidative phosphorylation ... inhibitor of calcineurin and P-glycoprotein, but it is also a stronginhibitor of the MPTP [18,19]. Indeed, it has been sug-gested that in several cell types CsA prevents opening of the MPTP, thereby...
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