... ARTICLE
Meiosis and small ubiquitin-related modifier (SUMO)-
conjugating enzyme, Ubc9
Kengo Sakaguchi, Akiyo Koshiyama and Kazuki Iwabata
Department of Applied Biological Science, Faculty of Science and ... with CcUbc9, CcTopII and CcPCNA. Moreover, both TopII
and PCNA homologs were known as Ubc9 interactors and the targets of
sumoylation. Immunocytochemistry demonstr...
... Inter-
national Conference on Acoustics, Speech and Signal
Processing, pages 181–184.
[Kurland and Lee2004] O. Kurland and L. Lee. 2004.
Corpus structure, language models, and ad-hoc infor-
mation retrieval. ... discounting (Witten and Bell,
1991), Jelinek-Mercer interpolation (Jelinek and
Mercer, 1980), and Kneser-Ney (Kneser and Ney,
1995).
In the information retrieval commu...
... dimers, with mono-
mers A and B in dimer 1 and C and D in dimer 2
(Fig. 8). The a-crystallin domain of each monomer is
composed of nine b-strands (labeled b2–b10), with the
b6 strand situated in a large ... formation
depends upon contact of b-strand 10 from the C-ter-
minal extensions of monomers A and D with
b-strands 4 and 8 in the a-crystallin domain of
monomers C and B, respec...
... Treatment with small interfering RNA affects the
microRNA pathway and causes unspecific defects
in zebrafish embryos
Xiao-Feng Zhao, Anders Fjose, Natalia Larsen, Jon V. Helvik and Øyvind Drivenes
Department ... efficiencies of different siRNAs and
related RNA molecules in inducing MMB defects. asGFP, antisense
strand of GFP; dsGFP, double-stranded GFP without 3¢-overhangs;
sGFP, sense s...
... evidence that complex size and chaper-
one activity are linked. Mutations, and N- and C-terminal
truncations of B. japonicum class A and class B proteins,
which led to smaller complexes, were accompanied ... temperature- and
concentration-dependent dissociations were fully reversible.
Complexes formed between sHsps and the model substrate
citratesynthasewerestableandexceededthesiz...
... Carbohydrate,
glycolysis
Lactococcus
lactis
Modeling Pi explicitly and regulation
of pyruvate kinase (by Pi and FBP),
PFK (by PEP) and GAPDH (by
NADH) are critical to describe
observations (rapid increase in PEP,
Pi and gradual decrease ... metabolite
concentrations and metabolic fluxes,
both measured and nonmeasured. A
general parameter sensitivity
analysis is carried out to deter...
... H4-K5, K8
and K12 acetylation [136–138]. In yeast, this group is
made up of NuA4 and Piccolo NuA4 which both uti-
lize Esa1 as the HAT, and Esa1 was found to be essen-
tial for H4-K5, K8 and K12 ... acetylation and deacetyla-
tion, and transient recruitment of remodellers and
transcription factors.
A cycle of transcription commences with the recruit-
ment of transcription factor...
... tumors and cell lines, miR-17-
5p and miR-20a are induced in a manner that depends
on cyclin D1 and repress the expression of cyclin D1.
Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedback
loop and ... transcription factors E2F and Myc but,
in turn, miR-17-92 downregulates the expression of
E2F and Myc [52]. In tumor progression, the tran-
scription repressors ZEB1 and SIP1...
... cancer.
DNMT 3A and 3B
DNMTs 1, 3A, and 3B are key DNA methylation
enzymes. Recent studies in human cells have demon-
strated that PRC2 and DNMTs are physically and
functionally linked [76], and that ... (Mathworks, Natick, MA,
USA), we compared localization and strand direction
between miRNAs and transcripts (Refseq genes and
mRNAs). Intragenic and intergenic miRNAs were de...
... disease and that,
when miR-1 is overexpressed in normal and infracted
rat hearts, this results in a slowed conduction velocity,
excessively prolonged repolarization and the induction
of PVCs and ... arrhythmias. On the other hand, blocking
miR-1 function with antisense oligoribonucleotides was
found to normalize the expression of Cx43 and Kir2.1,
prevent QRS and QT prolongation,...