... Bcl-2- bindingdomain which may serve as a point of cross-talk between the autophagic and apoptotic pathways. Recently, aBH3 domain in the Bcl-2- binding domain of Beclin 1was shown to bind to Bcl-XL[13]. ... of the autophagosomes and cargo by lysosomal proteases [2,3]. The autophagic pathway is crucial for maintainingcell homeostasis and disruption to the pathway can bea contributing factor to ... linked to, but distinct from, apoptosis [9,10].Beclin 1, a class III phosphatidylinositol 3-kinase-interacting protein [11], plays a role in promotingautophagy [12]. Beclin 1 contains a Bcl-2- bindingdomain...