Báo cáo khoa học: Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism potx

Báo cáo khoa học: Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism potx

Báo cáo khoa học: Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism potx

... transfer in cytochrome P450 reductase FEBS Journal 275 (2008) 454 0–4 557 ª 2008 The Authors Journal compilation ª 2008 FEBS 4557 Inter-flavin electron transfer in cytochrome P450 reductase – effects of ... The role of cysteine 566 in catalysis and cofactor binding. J Biol Chem 266, 1997 6–1 9980. 26 Shen AL & Kasper CB (1995) Role of acidic resi...
Ngày tải lên : 07/03/2014, 06:20
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Báo cáo khoa học: Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding docx

Báo cáo khoa học: Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding docx

... folded domains: an FAD- and NADPH-binding domain related to ferredoxin-NADP + reductase, a flavo- doxin-like FMN-binding domain and a connecting ÔlinkerÕ domain. In addition to the cytochromes P450, ... kinetic experiments to include studies of internal electron transfer in the presence of NADPH, NADH and fragments of nicotinamide coenzymes. We show that binding of the...
Ngày tải lên : 23/03/2014, 17:22
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx

Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx

... regulation of transferrin binding Previous reports have established that in certain cell types HFE acts to regulate intracellular iron levels by decreasing the binding of transferrin to transferrin receptors ... striking decrease in cell-surface bind- ing of transferrin, and that little or no reduction in transferrin binding was observed in cells expressing the HFE-C282Y mutan...
Ngày tải lên : 06/03/2014, 22:21
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Báo cáo khoa học: Testosterone 1b-hydroxylation by human cytochrome P450 3A4 pdf

Báo cáo khoa học: Testosterone 1b-hydroxylation by human cytochrome P450 3A4 pdf

... [26] using a single testosterone concentration of 100 l M . – Indic ates rate < 0.1 min )1 . P450 Rate (min )1 ) 1b-OH 2b-OH 6b-OH 15b-OH 1A1 – – 1.1 ± 0.1 – 1A2 – – 6.7 ± 0.3 – 1B1 – – 7.7 ... baculovirus-infected insect cells contain- ing 4 pmol of P450 3A4. (Varying amounts of P450 were used because of differences in rates of the systems, i...
Ngày tải lên : 07/03/2014, 16:20
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt

Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt

... plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin. Biochim. Biophys. Acta 1078, 2 3–3 0. 24. ... overlapping binding site on thrombin At this point, the mechanism of the inhibitory effect of TM on the interaction between PAI-1 and thrombin remains to be elucidated. To...
Ngày tải lên : 23/03/2014, 17:21
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Tài liệu Báo cáo khoa học: A novel electron transport system for thermostable CYP175A1 from Thermus thermophilus HB27 doc

Tài liệu Báo cáo khoa học: A novel electron transport system for thermostable CYP175A1 from Thermus thermophilus HB27 doc

... 1748 6– 17500. 30 Sielaff B & Andreesen JR (2005) Kinetic and binding studies with purified recombinant proteins ferredoxin reductase, ferredoxin and cytochrome P450 comprising the morpholine mono-oxygenase ... potassium phosphate buffer (pH 6.3) containing 10% glycerol and 100 mm KCl, CYP175A1 was eluted with a linear gradient of 10 0–6 00 mm KCl in 50 mm potassium ph...
Ngày tải lên : 18/02/2014, 08:20
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Báo cáo khoa học: "Simultaneous English-Japanese Spoken Language Translation Based on Incremental Dependency Parsing and Transfer" pot

Báo cáo khoa học: "Simultaneous English-Japanese Spoken Language Translation Based on Incremental Dependency Parsing and Transfer" pot

... In addition, we outline an approach of si- multaneous machine translation utilizing linguis- tic phenomena, flexible word order, and inversion, characterizing Japanese speech. 2.1 Difference of ... English speech transcript into Japanese incrementally. It is composed of three modules: incremental parsing, transfer and generation. In the parsing module the parser deter- mines th...
Ngày tải lên : 23/03/2014, 18:20
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Báo cáo khoa học: A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ pdf

Báo cáo khoa học: A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ pdf

... proteins. a-Actinin–stFRET (A), a-actinin–GFP (B), filamin A–stFRET (C), filam- in A–CFP (D), spectrin–stFRET (E) and spectrin–CFP (F) in 3T3 fibro- blast cells; Collagen-19–stFRET (G) and COL-19–GFP (H) in C. ... stretching of the coiled-coil myosin II [44]. Schweiger et al. [45] obtained a three-phase force–distance relationship: a linear phase of $ 1mNÆm )1 , a plateau of $ 25...
Ngày tải lên : 30/03/2014, 04:20
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Tài liệu Báo cáo khoa học: Diol dehydratase-reactivating factor is a reactivase – evidence for multiple turnovers and subunit swapping with diol dehydratase pdf

Tài liệu Báo cáo khoa học: Diol dehydratase-reactivating factor is a reactivase – evidence for multiple turnovers and subunit swapping with diol dehydratase pdf

... cobalamin at 0 min (thick solid line), 30 min (thin solid line), 60 min (thin long-dashed line), 120 min (thin short-dashed line), 240 min (thin dotted line) and 360 min (thick dotted line) of incubation, ... model of damaged cofactors) for free adeninylpentylcobalamin (AdePeCbl) (an inactive coenzyme analog containing the adenine ring in the upper axial ligand; a model of intact co...
Ngày tải lên : 15/02/2014, 01:20
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Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx

Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx

... C 5 -domain, catalyzing the intramolecular nucleophilic attack of the L-hOrn 3 a-amino group onto l-haOrn 4 . Taking into account that the synthetases involved in the bio- synthesis of the DKP-inheriting ... (solvent B) at a flow rate of 0.3 mLÆmin )1 : lin- ear increase from 0% B to 50% within 20 min followed by a linear increase to 95% B in 5 min, holding B for an additional 5 min...
Ngày tải lên : 16/02/2014, 09:20
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