Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc
Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc
... the involvement of lysine- containing sequences in the acti-vation mechanism. Involvement of lysine residues contained withina1CB6 peptides In order to localize lysine residues in sequencesinvolved ... derived from jararhagin disin-tegrin) is essential for binding to the I domain of a2integrins [24]. Similarly, members of the lysine threo-nine–serine (KTS)–disintegrin’ family contain theconsensus ... than RGD, in theirintegrin- binding loop [25,26]. In addition, glycation of collagen lysine side chains is responsible for animpaired interaction of type I collagen with b1inte-grins [27,28]....
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Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc
... spicule (Fig. 2H). These silica vesiclesoften remain as intact entities within the rings ⁄ cylin-ders, reacting positively to anti-silicatein (Fig. 2H).Catalytic function of silicatein: silica ... polymerase activity of silicatein, involvesstepwise addition of single silica monomeric units. Thisfinding implies that silicatein has two differentenzymatic properties, a silica esterase activity and ... experimental data show that, in additionto its silica polymerase activity, silicatein also comprisesa silica esterase function, thus supporting the conceptthat silicatein is involved in stabilization...
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Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx
... carbinolamine intermediate;III, iminoquinone intermediate; IV, product Schiff base intermediate;V, aminoquinol intermediate. In the oxidative half-reaction the ami-noquinol intermediate is ... identified in plots of klim⁄ Kd of pKavalues 7.1 and 9.3,again with the maximum value realized in the alkaline region. The poten-tial origin of these kinetically in uential ionizations is discussed.AbbreviationsAADH, ... (klim) for TTQreduction is controlled by a single ionization with pKavalue of 6.0, withmaximum activity realized in the alkaline region. Two kinetically in uentialionizations were identified...
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Báo cáo khoa học: Inter-flavin electron transfer in cytochrome P450 reductase – effects of solvent and pH identify hidden complexity in mechanism potx
... Characterization of hydride transfer to flavin adenine dinucleotide in neuro-nal nitric oxide synthase reductase domain: geometricrelationship between the nicotinamide and isoalloxazinerings. ... compilation ª 2008 FEBSerrors in the estimation of the midpoint potentials.However, it is more likely that there is thermodynamicmixing of the species during potentiometric titration, i. e. ... FMN-containing flavodoxin and aFAD-binding ferredoxin-NADP+reductase [2,3,6].This is also reflected in its domain organization deter-mined by X-ray crystallography of rat CPR, with thetwo flavin...
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Báo cáo khoa học: Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx
... andthis will affect the strength of coenzyme B binding. Amore important function of the methyl group mayinvolved improved orientation of the histidine insidethe coenzyme B-binding site. With ... andMoaD, involved in thiamine biosynthesis and molyb-dopterin biosynthesis, respectively, and for the sulfura-tion of uridine in tRNA to thiouridine can beenvisaged [34–36]. This mechanism probably ... with fully overlapping orbitals. Owing to thepositive inductive effect, the pKa of the methylatedamino acid is expected to increase slightly (imidazoleand N-methylimidazole differ in their...
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Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf
... resi-dues in close proximity to the bound substrate in TOP,including Tyr612 and residues contained in the loopregion 599–611 that join domain I and II. Supportedby computational studies, activity ... both impli-cated in substrate binding, are shown in Fig. 3 to bewithin hydrogen bonding distance from the substrate.As energy minimization only allows for limited con-formational sampling, ... dipeptidyl pepti-dase III (DPP III), indicating similar transition statestabilizations during the catalytic event [21,23–26].Possibility that mcaBk could be cleaved by anopen form of the...
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Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc
... in macrophages by stimulating incorpor-ation of acyl-CoA into TG as well as by inhibition of fatty acid oxidation. This contrasts with findings in ADRP-deficient mice, in which no difference in ... loading with VLDL. In contrast, inhibition of adipo-philin expression using siRNA prevented lipid-droplet formation and signi-ficantly reduced intracellular triglyceride content. Using inhibitors ... absence of VLDL(control cells), nominal diffuse cytoplasmic adipophilinstaining was observed (Fig. 4A); in the presence of VLDL, adipophilin staining was pronounced in bothAd.CMV.adipophilin-...
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Báo cáo khoa học: An important lysine residue in copper⁄quinone-containing amine oxidases doc
... compilation ª 2007 FEBSOxidative deamination of a lysine residueThe oxidative deamination of a lysine residue wasmonitored through the formation of a-aminoadipic-d-semialdehyde-derivatized ... DABY inhibitionmechanism; that is, the reactive turnover product of DABY binds an amino acid residue without interferingwith the TPQ function.Discussion In the past decade, several interesting ... amino acid residue is impli-cated in the mechanism-based inhibition that is dif-ferent from the residue implicated in TPQ reductionunder xenon pressure. A nucleophile residue isimplicated in...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
... structural organization thatincludes a DNA-binding domain, a ligand-bindingdomain and a transactivation domain. The DNA-bind-ing domain is responsible for DNA binding specificityand dimerization, and ... AT-hook is a DNA-binding domain. Bromodomains (BROMO) are involved in the recognition of acetylated lysine residues in histone tails. CXXC-zf is a Zn-finger domain involved in protein–protein interactions. ... loss of MLL1 functionimpairs RNAPII distribution [30]. These observationsindicate that an intimate association of MLL andRNAPII is required for transcription initiation and ⁄ orthe elongation...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... presence of thapsigargin. However, in contrast to a report onpancreatic acinar cells, where PI3-K inhibitionincreased Ca2+mobilization via SERCA activation [30], PI-3K inhibition did not alter ... antagonized this effect(Fig. 4A). In marked contrast, preincubation with thePI3-K inhibitor wortmannin was ineffective.Further experiments confirmed the sensitivity of InsP3-induced Ca2+mobilization ... thethrombin-induced Ca2+response in a way not onlyinvolving adenylyl cyclase ⁄ PKA inhibition, but also byPI3-K stimulation. P2Y12appears to increase InsP3receptor function via PKA inhibition....
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