Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
... hypophosphatasia with
tissue-nonspecific alkaline phosphatase bearing
a conservative replacement of valine by alanine at
position 406
Structural importance of the crown domain
Natsuko Numa
1
, Yoko ... characterized by reduced
serum alkaline phosphatase levels and defective mineralization of hard tis-
sues. A replacement of valine wi...
... AMPA
pathway), referred to as the GOX pathway.
(B) Reaction catalyzed by GO on glyphosate,
an alternative to the AMPA pathway as
catalyzed by GOX.
Mechanisms of glyphosate resistance L. Pollegioni et al.
2758 ... most
glyphosate-resistant biotypes. In the case of Conyza
canadensis, glyphosate accumulates in vacuoles of resis-
tant plants at a markedly faster rate than in s...
... Koike Y, Nohata J,
Kawasaki H, Kadono-Okuda K, Yamamoto K,
Suzuki MG, Shimada T et al. (2003) The construction
of an EST database for Bombyx mori and
its application. Proc Natl Acad Sci USA 100, 14121–
14126.
27 ... Cleavage of structural proteins
during assembly of head of bacteriophage-T4. Nature
227, 680–685.
31 Daimon T, Katsuma S, Iwanaga M, Kang W &
Shimada T (2005) The...
... RT-PCR with a Thermal Cycler Dice Real
Time System (TaKaRa Bio Inc.). Forward primers 5¢-CG
TTTGAAGGGTGAGGAGGAAAA[FAM]G-3¢ and 5¢-CA
CAAGAGAGTTCTGCGATAACCTTG[FAM]G-3¢ (Invi-
trogen Corporation) and ... reverse primers 5¢-AAGTAGGCA
ACAAAACAACG-3¢ and 5¢-GTTTTCCCGACAATAA-
CATGG-3¢ were used for detecting GmPDIL- 3a and
GmPDIL-3b, respectively. Primers for quantification of
actin mRNA were...
... (Table 3). Secondary antibodies
(anti-rat IgG, anti-guinea pig IgG and anti-rabbit IgG; all
raised in goat and conjugated to alkaline- phosphatase;
Sigma, Saint Louis, MO, USA) were used at 1 : 2000 ... profile of an acetic acid extract of 30 lobster sinus
glands. Only the part of the chromatogram where CHHs and VIHs
are eluted is shown. The nature of the ultraviolet absor...
... the Verlet leap-
frog algorithm and the nonbonded interactions truncated
with a 10 A
˚
cutoff. The temperature of the system was reg-
ulated by the Langevin thermostat to maintain the tempera-
ture ... carbohydrate conformation. Proc Natl Acad
Sci U S A 98, 10541–10545.
35 Basma M, Sundara S, Calgan D, Venali T & Woods RJ
(2001) Solvated ensemble averaging in the...
... dependent on activation of the extracellu-
lar regulated kinase MAPK. The activation of MAPK
is also important in regulating the RA FLS cytoskeletal
structure and migration by fractalkine ⁄ CX3CL1 ... Immunolocalization
analysis indicated that IP-10 ⁄ CXCL10 is associated
mainly with infiltrating macrophage-like cells and
fibroblast-like cells in the RA synovium, and the inter...
... factor-jB and extracellular signal-regu-
lated kinase signaling cascades. In addition, AhR
expression in synovial cells was upregulated by TNF -a.
These data suggest that TNF -a activates AhR expres-
sion ... pregnancy
are at the greatest risk of developing RA [45]. These
researchers also suggested that the association among
breastfeeding, pregnancy and RA may be related to
either...
... we also found that SAA stimulation
promoted nuclear translocation of NF-jB, whereas
pre-incubation of SAA with RAGE inhibited nuclear
translocation [12]. These data suggested that SAA of
RA joints ... colony-stimulating factor.
RANKL activates the TNF receptor-associated factor
6, c-Fos, and calcium signaling pathways, all of
which are indispensable for the induction and activa-...