Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
... Journal compilation ª 2008 FEBS Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells Min-Jung Kim1, Kee-Ho Lee2and ... targets for cancer treatment.ResultsTo examine the kinetics of the apoptotic cell death induced by ionizing radiation in human cervical cancer cells, we treated HeLa cells with 10 Gy radiation, ... Ionizing radiation induces expression of Fas and activation of caspases in human cervical cancer cells. (A) Ionizing radiation- induced apoptotic cell death. HeLa cells were treated with 10 Gy of...
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Báo cáo khoa học: Gc recruitment system incorporating a novel signal amplification circuit to screen transient protein-protein interactions pot
... and it therefore allows for cellular changes in the mating pro-cess. Therefore, the generation of diploid cells with opposite mating-type cells can be used to screen interacting protein pairs, ... withintact a cells. The formation of diploid cells in mediumlacking methionine and lysine depends on the affinities of the protein pairs [12].To verify our hypothesis that the incorporation of ... detectable formation of diploid cells in the control strain without interactingprotein pairs (Fig. 2; None–Fc; 82 diploid cell countsgenerated in an equivalent volume of 1 mL of cell suspension,...
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Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx
... (solvent B) at a flow rate of 0.3 mLÆmin)1: lin-ear increase from 0% B to 50% within 20 min followed bya linear increase to 95% B in 5 min, holding B for anadditional 5 min. This gradient was ... 673Determination of amino acid connectivity viapartial hydrolysis of erythrochelinThree milligrams of erythrochelin were partially hydrolyzed in 200 lLof6m HCl at 110 °C for 20 min. The result-ing ... biosyntheticmachinery governing foroxymithine assembly. Futurework will focus on the investigation of erythrochelin-mediated angiotensin-converting enzyme inhibition,aiming to assign a bioactivity going...
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Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx
... more in WAT of TGmice than in WAT of WT mice.Serum levels of triglyceride, glucose, leptin andinsulin, and insulin sensitivity, in TG miceAfter 6 weeks of normal or HF diet, serum levels of triglyceride, ... regulation of insulin produc-tion in pancreatic islet cells [39–41]. Thus, theincreased insulin level seen in H-PGDS TG mice whenon the HF diet might be due to effects of PGD2onpancreatic islet cells. ... activation of PPARc in WAT, it ispossible that PGD2stimulates pancreatic islets toincrease insulin secretion. Indeed, serum insulin levelswere increased after treatment with thiazolidinedionesin...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc
... be a sink for Cu(I). This couldbe sufficient for a redox-silencing role of MT3 for Cu. In this context it might be interesting to search for possible binding partners of Cu(I)4MT3.Since the ... occurred in the Zn cluster [32]. Indeed, exposure of Cu(I)4-Zn4MT3 to air resulted in the slow formation of adisulfide linkage by cysteine oxidation of the a-domainand a concominant release of ... dynamics shouldalso result in a faster metal transfer from and to MT3and hence is in line with an involvement in the traffick-ing of Zn(II) in particular in zinc-containing neurons[41]. However,...
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Tài liệu Báo cáo khoa học: Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma pptx
... weredetermined by SDS-PAGE followed by silver staining.Preparation of mouse activated protein CIncubation of mouse protein C with human or bovinethrombin using conditions known to work well for human protein ... randomized. No binding was detected in buffer lacking Ca2+ for any of the proteins tested.Protein binding equilibrium data (Req) were fitted to a one-site binding hyperbola according to the relationship ... saturation binding levels of the protein C variantswere compared, for any of the phospholipid mem-branes tested, implying a different mode of bindingbetween the proteins. This indicates that...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... interface [8,9]. BTB ⁄ POZ proteins areoften transcriptional regulators containing a C2H2domain for DNA binding, but can also be found in combination with various other protein–protein inter-action ... proteins use their BTB ⁄ POZ domain to interactwith the cullins CUL3A and CUL3B [3,4,16], we inves-tigated what kind of protein–protein interactions werefacilitated by their MATH domains by ... proPRAP2.4:GUS lines showed blue staining in cotyledons of 3-day-old seedlings, but not in parts of the hypocotyls (Fig. 4G). In rosette leaves, weobserved expression in the vascular tissue of the leafblade,...
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Tài liệu Báo cáo khoa học: The yeast ubiquitin ligase Rsp5 downregulates the alpha subunit of nascent polypeptide-associated complex Egd2 under stress conditions docx
... ormis-folding of proteins may also be a signal for ubiqui-tination of denatured proteins that are recognized bythe appropriate ubiquitin ligase. In human cells, block-ing of the metabolism of mis-folded ... the stability of Egd2 wasdecreased in wild-type cells but not in rsp5 mutant cells in the absence of CX (Fig. 2A). However, in the pres-ence of CX, Egd2 levels were decreased in both thewild-type ... the level of Egd2 in the rsp5 mutant cells (CHE81) remained stable (Fig. 2A). However, in thepresence of CX, the amount of Egd2 was decreased in both the wild-type and rsp5 mutant cells after...
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Tài liệu Báo cáo khoa học: TransLISA, a novel quantitative, nonradioactive assay for transcription factor DNA-binding analyses pdf
... 8.4-foldinduction of HSF1 DNA-binding in heat-shockedHeLa cells, and, on average, 25.8-fold induction of HSF1 DNA-binding in heat-shocked MEFs whencompared to the untreated cells. The results are well in line ... through the DNA-binding domain.Stable binding requires simultaneous binding of allDNA-binding domains in a trimer to three adjacentnGAAn repeats. Therefore, a functional HSE containsat least ... determin-ing binding affinities for transcription factor–DNAbinding.The results of measurements of HSF1 DNA-bindingactivity from HeLa cells and MEFs are in line withresults reported in several other...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... role in intracellularsignalling and thus in cell physiology and cellulardestruction. ROS are known to induce a wide range of responses, depending on cell type and levels of ROSwithin the cell ... 2¢,7¢-dichlorodihydrofluorescein diacetate; DR-5, death receptor-5; JC-1, 5,5¢,6,6¢-tetrachloro-1,1¢3,3¢-tetraethylbenzimidazol-carbocyanine iodide; JNK, c-Jun N-terminal kinase; JNK-SAPK, c-Jun N-terminal kinase- stress-activated ... Oya M, Mizuno R, ShinojimaT, Marumo K & Murai M (2004) Inhibition of theubiquitin-proteasome pathway activates stress kinasesand induces apoptosis in renal cancer cells. Int J Oncol25, 697–702.14...
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Từ khóa: Nghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDENghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM