... FEBS. No claim to original French government works 735
Arabidopsis thaliana CYP77A4 is the first cytochrome
P450 able to catalyze the epoxidation of free fatty
acids in plants
Vincent Sauveplane
1
, ... unsaturated C
18
fatty acids. This is also
the first report describing a cytochrome P450 which
can catalyze the epoxidation of f...
... BPM1
version of 151 amino acids [BPM1(1–151)] comprising
the first 38 amino acids of BPM1 followed by the com-
plete MATH domain. As shown in Fig. 2A, BPM1(1–
151) is entirely capable of binding to GST:RAP2.4, ... assemble
with other proteins either in the nucleus or the cyto-
plasm.
Discussion
This work provides novel information, including the
first descrip...
... C-terminus of PEA is essential
for the cytotoxicity of the endocytosed toxin, allowing
PEA to reach its site of action [2,5]. This implies that
PEA may interact with the KDEL receptor in order to
traffic ... oocytes, but the oocytes could be pro-
tected from autointoxication by injecting neutralizing
antisaporin antibodies into the cytosol [22]. The
mechanism(s) under...
... grouped into three
main classes of PDZ binding motifs, occurring at the
C-terminus of the interacting proteins [16]. We scanned
the human olfactory receptor repertoire for putative
binding motifs ... tested
binding of single PDZ domains 1 + 2, and found that
both could bind to the OR C-terminus (Fig. 2D).
Next, we investigated the ability of PDZ domains
1 + 2 to bind to...
... suggested the unwinding of the
single a-helix at the C-terminal portion of c, thus allowing
for unimpaired rotation of the remainder of c.Furthermore,
the calculations suggested the very end of c to ... summarized
in Fig. 5.
The emerging picture is that the central shaft of F
1
never
comes to a full halt; c is free to slowly rotate back and forth
in...
... cloned into the 3¢ UTR of the luciferase
gene of 3.1-luc. The VEGF-FL-luc construct contains nt
209–1747 of the mVEGF 3¢ UTR where nt 1 is the first
base of the VEGF stop codon [34] (identical to ... 2005)
doi:10.1111/j.1742-4658.2006.05106.x
The macrophage is critical to the innate immune response and contributes
to human diseases, including in ammatory...
... Within
resting cells, NF-jB is retained in the cytoplasm complexed
to an inhibitor protein from the IjB family [3]. Stimulation
with pro -in ammatory cytokines, such as tumour necrosis
factor ... protein was rapidly
induced (Fig. 1). This was first apparent by 2 h poststim-
ulation and levels of ICAM-1 protein continued to rise over
the 18 h of the experiment. To exam...
... inclusions of neuroserpin within c ortical a nd subcortical
neurons [1–3]. Neuroserpin is a member of the serine
proteinase inhibitor or serpin s uperfamily. It inhibits the
enzyme tissue plasminogen ... Neuroserpin polymers result from the sequential
insertion of t he reactive centre loop of one molecule into
b-sheet A of another [1,6]. The resulting s pecies is inactiv...
... leads
to glucocorticoid resistance in a number of pathological
conditions [24]. In the case of the mineralocorticoid
receptor a variant lacking the hinge and ligand-binding
regions but able to increase ... [14]. They are organized in a
modular fashion and act by binding to DNA
response elements found in the regulatory regions of
their target genes [14]. Due to...
... has
been shown to form a complex with the adaptor pro-
tein Fe65 and the histone acetyltransferase Tip60 that
is capable of inducing transcription of reporter genes
[44]. The ability to form transcriptionally ... cleavage and binding to FE65 regulate
the nuclear translocation of the intracellular C-terminal
domain (ICD) of the APP family of proteins. Biochem-
ist...