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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx

Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx

Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx

... Tokyo, Japan). The following primers wereused: b-actin: forward, 5¢-TGACAGGATGCAGAAGGAGA; reverse, 5¢-GCTGGAAGGTGGACAGTGAG; CD68:forward, 5¢-TCTACCTGGACTACATGGCGGTGG; reverse,5¢-ACATGGCCCGAAGTGTCCCTTGTC. ... serum activator of single-chain precursor macrophage-stimulating proteinMakiko Kawaguchi, Hiroshi Orikawa, Takashi Baba, Tsuyoshi Fukushima and Hiroaki KataokaSection of Oncopathology and Regenerative ... approxi-mately 60 kDa, presumably the a chain of matureMSP (Fig. 1A) . Generation of a band of approxi-mately 30 kDa, presumably the b chain, was alsodetected by an anti-His tag IgG (Fig. 1A) . Cleavagesite...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... Diagnostics, Aichi Cancer Center Hospital, Nagoya, JapanIdentification of epidermal growth factor, epidermal growth factor receptor and ERBB family proteins Epidermal growth factor (EGF) was originally ... sensitivity in lung cancer. Cancer Sci 98, 181 7–1 824.13 Kosaka T, Yatabe Y, Endoh H, Kuwano H, TakahashiT & Mitsudomi T (2004) Mutations of the epidermal growth factor receptor gene in lung cancer: ... non-smallcell lung cancers. ALK translocation was associatedwith patients being never-smokers of a youngerage and acinar-type adenocarcinomas, in a larger study[29]. It is also noteworthy that...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... K, Uchida Y, KoyamaN, Murayama Y, Tanaka T, Miyazawa H, Nagata M,Kanazawa M et al. (2006) Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations ... phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations. Lung Cancer 64,31 4–3 18.22 Morita S, Okamoto I, Kobayashi K, Yamazaki K,Asahina ... JapanKRAS mutations and sensitivity totherapy with mAb to epidermal growth factor receptor in colorectal cancer Cetuximab is a chimeric mouse–human mAb that tar-gets the extracellular domain...
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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx

Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p a metastatic inhibitor of lung cancer potx

... Epidermal growth factor receptor-regulated miR-12 5a- 5p a metastatic inhibitor of lung cancer Guofu Wang1,2, Weimin Mao1, Shu Zheng2and Jingjia Ye21 Department of Respiratory Disease, ... expression of several downstream genes of epidermal growth factor receptor signaling. Importantly, examination of lung cancer samples revealed a significant correlation of miR-12 5a- 5p repression with lung ... frequentlydecreased in lung cancer patients. Our data stronglyimplicate miR-12 5a- 5p as a potential inhibitor of tumor metastasis.ResultsRepression of miR-12 5a- 5p in response to EGFRactivation in lung cancer...
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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf

... Miyazawa K, Tsubouchi H, Naka D, Takahashi K,Okigaki M, Arakaki N, Nakayama H, Hirono S,Sakiyama O, Takahashi K et al. (1989) Molecularcloning and sequence analysis of cDNA for humanhepatocyte ... expression of humanhepatocyte growth factor. Nature 342, 44 0–4 43.6 Miyazawa K, Kitamura A, Naka D & Kitamura N(1991) An alternatively processed mRNA generatedfrom human hepatocyte growth factor ... proliferation and migration of epithelial cells to repair the tissue architecture. FVa, factor Va; FXa, factor Xa; FXIIIa, activated FXIII.K. Miyazawa Hepatocyte growth factor activatorFEBS Journal...
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Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf

Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf

... TA, Cruz CP, Fan CY, Brown AT,Wang Y, Eidt JF & Moursi MM (2003) Saratin, an inhibitor of collagen–platelet interaction, decreasesvenous anastomotic intimal hyperplasia in a caninedialysis ... of von Willebrand factor- dependent platelet adhesion,decreases platelet aggregation and intimal hyperplasia in a rat carotid endarterectomy model. J Vasc Surg 34,72 4–7 29.20 Smith TP, Alshafie ... Condra C, Karczewski J &Connolly TM (1992) An inhibitor of collagen-stimulatedplatelet activation from the salivary glands of the Hae-menteria of cinalis leech. II. Cloning of the cDNA andexpression....
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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1) doc

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1) doc

... substratespro-hepatocyte growth factor and pro-macrophage-stimulating protein.AbbreviationsEGF, epidermal growth factor; HAI, hepatocyte growth factor activator inhibitor; HGFA, hepatocyte growth ... HGFA (96 kDa) has the samedomain architecture as coagulation factor XII: anN-terminal fibronectin type II domain, an epidermal growth factor (EGF)-like domain, a fibronectin type Idomain, a second ... MINIREVIEWHepatocyte growth factor activator (HGFA): molecularstructure and interactions with HGFA inhibitor- 1 (HAI-1)Charles Eigenbrot1,2, Rajkumar Ganesan3and Daniel Kirchhofer31 Department of...
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Báo cáo khóa học: Nerve growth factor mediates activation of the Smad pathway in PC12 cells doc

Báo cáo khóa học: Nerve growth factor mediates activation of the Smad pathway in PC12 cells doc

... the nuclear fraction after 5 min of ligandstimulation and the amount of nuclear Smad3 increaseswith prolonged growth factor treatment, reaching a maxi-mum after 1 5–3 0 min of stimulation with ... #1D11) was purchased from R&D Systems. Details of polyclonal antisera against Smad2 (anti-S2), Smad3(anti-S3) and C-terminally phosphorylated forms of Smad1 (anti-PS1) and Smad2 (anti-PS2) were ... for example, can be impaired by epidermal growth factor and hepatocyte growth factor, which lead to thephosphorylation of Smad1 in the linker region and thusprevent Smad1 nuclear translocation...
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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor ppt

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor ppt

... Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor. Biochemistry 27, 423 1–4 237.8 Wakita T, Hayashi T, Tamaru H, Nishioka J, AkitaN, Asanuma K, Kamada H, Gabazza EC, ... plasma of normal individuals. Thus, PCImay play a role as a potent inhibitor of HGFA and APC in plasma and ⁄ orat the sites of tissue injury in the regulation of tissue regeneration.AbbreviationsAPC, ... C inhibitor (PCI; SERPINA5), a member of the plasma serine protease inhibitor (serpin) family, wasisolated from human plasma as an inhibitor of activatedprotein C (APC), the major protease of...
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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): pathophysiological functionsin vivo potx

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): pathophysiological functionsin vivo potx

... February2010)doi:10.1111/j.1742-4658.2010.07640.xHepatocyte growth factor activator (HGFA) is a serine protease initiallyidentified as a potent activator of hepatocyte growth factor ⁄ scatter factor. Hepatocyte growth factor ⁄ scatter factor ... factor activa-tor. J Biol Chem 271, 361 5–3 618.25 Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y& Kataoka H (2008) Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human ... Matsumoto K & Nakamura T (2006) Hepatocyte growth factor and the Met system as a mediator of tumor–stromal interactions. Int J Cancer 119, 47 7–4 83.2 Kataoka H, Miyata S, Uchinokura S & Itoh...
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