Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... effect of HFE binding to TfR1 is to lower the affinity of the receptor for transferrin [15]. This mostlikely reflects the existence of overlapping HFE and transferrin- binding sites on the receptor ... FEBS N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding Lavinia Bhatt1, Claire Murphy2, Liam S.O’Driscoll2, ... (N110, N130 and N234), and that mutation of these sites gives rise to an HFE protein that is N-glycosylation deficient. N-Glycosylation of HFE is required for its appropriate localization to the ERCOur...
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Báo cáo khoa học: YidC is required for the assembly of the MscL homopentameric pore potx
... in the earlier study [13], is located adjacent to the centre of the pore-forming TM1. It is thereforeconceivable that even a slight perturbation of the conformation of MscL, for example due to ... equal to that of the non-depleted IMVs. Thisindicates that YidC is required for assembly of the MscL complex (Fig. 5). To investigate the role of the Sec translocon in for- mation of the MscL–HA ... YidC but is not affected by depletion of SecE. Native gel analy-sis of the IMVs used in Fig. 4, to monitor the effect of YidC, SecE and SRP depletion on the level of the MscL pentamer in the innermembrane....
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
... in the stearicacid incorporation after the de novo synthesis of thislipid (i.e. the second hypothesis). According to thishypothesis, previously raised for mammals [34–36], the decrease in the ... specific decrease in the de novo synthesis of a given phospholipid, includingPI. Hence, the rate of synthesis and the amount of CDP-DAG molecules that were used as substrate for PI synthesis appeared ... syn-thesized in mutant cells and therefore a decrease in the content of PI in psi1D cells (and consequently anincrease in the percentage of the other phospholipids)could be expected.This was...
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Báo cáo khoa học: "A Clustering Approach for the Nearly Unsupervised Recognition of Nonliteral Language" pdf
... (“he wasforced to eat his spinach” vs. “he was forced to eathis words”) or our knowledge of the world ( the sponge absorbed the water” vs. the companyabsorbed the loss”). Nonliteral is then anythingthat ... where theybelong. Since this baseline actually attempts to distinguish between literal and nonliteral and usesall the data used by the TroFi algorithm, it is the one we will refer to in our discussion ... trigramcomposed of the SuperTag of the target word and the following two words and their SuperTags ifthey contain nouns, prepositions, particles, or ad-verbs. This is helpful in cases where the sameset of...
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Báo cáo khoa học: Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system potx
... the BLASTPprogram and the amino acid sequences of human and S. cerevisiae TFIIE, TFIIF and TFIIB, and of the p62subunit of human TFIIH. We identified homologs of both subunits of TFIIE, TFIIF and TFIIB, and of ... appears to be the homolog of TFIID in higher eukaryotes, as it possessesTAF110, which is the homolog of human TAFII250. Also,TAF72 of Sc. pombe is the homolog of human TAFII100(isoform 1). For these ... Materials and methods with 50 ng of the Ad-MLP promoter and the amounts of RNAPII holoenzyme, RNAPII,activators, and GTFs indicated at the bottom of each panel. (A) Analysis of the amount of transcriptional...
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Tài liệu Báo cáo khoa học: "Incorporating Context Information for the Extraction of Terms" pdf
... list presents the higher density on terms among any other part of the list. This top of the list, or else, the 'first' of these ranked candidate terms will give the weights to the ... otherwise (2) a is the examined string, lal the length of a in terms of number of words, f(a) the frequency of a in the corpus, Ta the set of candidate terms that contain a, P(T~) the ... number of these candidate terms. At this point the incorporation of the context in- formation will take place. Step 3: Since C-value is a measure for extract- ing terms, the top of the previously...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... pre-cipitate sinking to the bottom of the cuvette and there-fore not obscuring the light path [42]. Thus, the Q194Amutant showed thermostability similar to that of wild-type Hsp25, whereas the glutamic ... oligomeric size of the E190Amutant compared with the wild-type suggests that the E190 residue is important for the correct formation of the quaternary structure of Hsp25. Examination of the crystal ... struc-ture and function of sHsps. The chaperone activity of Hsp30C is impaired when the polarity of the C-termi-nal extension is reduced [25], and introduction of hydrophobicity into the C-terminal...
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Báo cáo khoa học: " An Input Device for the Harvard Automatic Dictionary" pot
... are the normal correspondents of the tokens. For example, while 0010011 is defined as a token for Й in the ranked code, it is nor- mally a token for the semi-colon. Therefore, since the output ... Russian into English. The normal mapping be- tween numbers, letters of the Roman alphabet, punctuation marks, and other standard symbols on the one hand, and machine tokens on the other, is given ... reference to the Univac I. The modified device is performing satisfactorily in the compilation and experimental operation of the Harvard Automatic Dictionary. THE PROPERTIES of a given automatic...
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Báo cáo khoa học: "A Formula Finder for the Automatic Synthesis of Translation Algorithms" docx
... encountered, the program specifies the truth values of the variables in Dr for the given values of i and j. The program then evaluates the truth value of Dr in terms of the truth values of the ... OPERATION OF THE FORMULA SYNTHESIZER The input to the final machine program shown in Fig. 4, called formula synthesizer, is the set of tally counts in the Xk and Yk registers. Its output is a ... pattern of type 1, 2, or 3 is present; the third output is always produced. The function of the third output is to facilitate the human monitoring and control of the formula synthesizing...
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Báo cáo khoa học: "Fast Syntactic Analysis for Statistical Language Modeling via Substructure Sharing and Uptraining" ppt
... dependent. si.nch is the number of children of a subtree. qi.w and qi.t are the word and its POS tag in the queue. dist(s0,s1) is the linear distancebetween the head-words of s0 and s1.subtrees ... models. The top-m candidate structures associated with the ithhy-pothesis, which we denote as s1i, . . . , smi, are gener-ated by these tools and used to score the hypothesis:F (wi, ... (2007) a heap is used to maintain states prioritized by their scores, for apply-ing the best-first strategy. For each step, a state from the top of the heap is considered and all actions (and scores)...
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