... 2010 The Authors Journal compilation ª 2010 FEBS Human lactoferrin activates NF-jB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling Ken ... instead of the CD 14 LPS complex, may be presented to TLR4, thereby triggering TLR4 activation through the carbo-hydrate chains of hLF. However, hLF may interfere with the formation of the CD 14 LPS ... resultingin the attenuation of LPS signaling. As LF is known tointeract with LPS, the binding of LPS with LBP mayalso be interfered with in the presence of hLF [9].Although the involvement of TLR4 in...