Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot

... haveshown that the costimulatory activity of CD26involves the ligand-binding domain [124,125]. A recent in vivo study using a DPIV-selective inhibitor in DPIVgko mice has further shown independence ... [77]. DPIV enzyme activity iseffective on a number of chemokines in vitro (Table 2).DPIV in cell biology A number of DPIV-binding proteins have been identi-ﬁed, including adenosine deaminase ... highlighted theirinteresting biological properties as enzymes in metabo-lism, cell biology and immunology (Fig. 5) and the need for further insight into the therapeutic potentialof DP inhibitors in...

Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc

... 670–711) and not in the DNA-binding domain (Fig. 6). These resultsprovide another convincing example highlighting the ABFig. 7. The glycosylated t runcated forms of HIC1 a re unable to bind their ... O-GlcNAcresidues did not interfere directly or indirectly with the DNA-binding activity, but their involvement in proteinstability or in protein–protein interaction had to beinvestigated. By contrast, ... against O-GlcNAc residues, fully corroboratedthese results. Interestingly, these truncated proteins areO-GlcNAc modiﬁed in their C-terminal tail (residues670–711) and not in the DNA-binding...

Báo cáo khoa học: "The Corpora Management System Based on Java and Oracle Technologies" potx

... in theirdaily work. The system offers facilities toassist linguists and internet users as theysearch for relevant material, and then clas-sify and annotate this material.1 IntroductionThere's ... support linguists in their daily work. The system offers facilities to assist linguists and inter-net users as they search for relevant material, and then classify and annotate this material in a ... managementsolutions and products that fall under the rubric"corpora and text mining". They are similar to datamining solutions in that they deal with large vol-umes of data, but the difference...

Báo cáo khoa học: Therapeutic targeting of molecules involved in leukocyte–endothelial cell interactions potx

... matrix and cell patho-gen interactions by binding to distinct, but overlapping,Table 2. Selectin, integrin and GPCR antagonists in clinical and preclinical studies. COPD, chronic obstructive pulmonary ... totransport the peptide across the cell membrane and tethers the pepducin to the inner leaﬂet of the lipidbilayer in molecular proximity to the intracellularloops of the receptor. Pepducins were ... by their ligands leads to the acti-vation of integrins, resulting in ﬁrm adhesion to the endothelium. Therefore, for many years, chemokinereceptors and their ligands have been an attractivehunting...

Tài liệu Báo cáo khoa học: The two Caenorhabditis elegans metallothioneins (CeMT-1 and CeMT-2) discriminate between essential zinc and toxic cadmium docx

... CeMT-2 is only induced in intestinal cells in the presence of cadmium, but CeMT-1is also constitutively active in three cells of the lowerpharyngeal bulb [24]. These studies provided the firstevidence ... to the wild-typestrain.Both CeMT-1 and CeMT-2 are important in maintaining physiological zinc levelsUnder control (non-metal-supplemented) conditions in the wild-type (N2), zinc was maintained ... Carlsbad,CA, USA) and positive clones were identified by PCRscreening. The identity of the insert was confirmed bysequencing both strands of the cloned inserts. In vitro protein expression and purificationPlasmids...

Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf

... elevated in human cancer cells [81,82], the HSE-binding activity of HSF1 might be higher in cancer cells than in normal cells. Even so, the HSE-binding activity is robustly induced in response ... mechanisms for cell proliferation and survival in cancer cells and in yeast cells.Is the HSF1 in cancer cells activated? As HSF1expression, which is correlated with HSE-bindingactivity [35], ... master regulator of these genes.Interestingly, the amino-terminal region of chickenHSF1 containing an alanine-rich sequence and the DNA-binding domain is sufﬁcient to cause the func-tional difference...

Tài liệu Báo cáo khoa học: The Mycobacterium tuberculosis membrane protein Rv2560 ) biochemical and functional studies pdf

... for the identiﬁcation of the HABPs interacting with U937 and A549 cells (in this case), their binding dissociationconstants, their critical binding residues and their role in cell invasion inhibition, ... well as the characterization of the high-activitybinding peptide (HABP) involved in the binding to and invasion of monocytes (U937) and type II alveolarepithelial cells (A549), using synthetic ... from the M. tuberculosis H37Rv strain. The peptides are given on the left-hand side, with numbers indi-cating their position within the native protein; in peptides that did not contain tyrosine,...

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... increase the activity of aB-crystallin against DTT-induced precipi-tation of insulin at intermediate and high concentra-tions, and it also increased the activity of aB-crystallin in preventing the ... no in uence of the additiveon the chaperone activity of aB-crystallin (i.e. the effect of the additive on the aggregation of the target protein is inde-pendent and different from that of the ... a change in the number of ﬁbrilsformed in the presence of these additives. In the presence of aB-crystallin (1.0 : 0.2 w ⁄ w ratio ofa-synucleinA53T : aB-crystallin), the increase in ThTﬂuorescence...

Tài liệu Báo cáo khoa học: The nuclear lamina Both a structural framework and a platform for genome organization pdf

... the nuclear periphery in two patient cell lines.Interestingly, the lamin A mutation in these two cell lines was within a DNA ⁄ chromatin binding domain[35].Further, we have found that in cells ... determining and supporting the position of the nucleus in the cell [62,63]. Now, the recent identiﬁcationof an interaction between the outer nuclear membraneprotein nesprin 3 and the intermediate ... these speciallamins are expressed in spermatocytes and oocytespossibly reﬂects the distinct organization of the nucleiof these cells in general and chromatin in particular in germ cells. Indeed,...

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... (rotationangle ‘r’) and variation of the inclination (inclination angle ‘i’) withrespect to the plane of the membrane (parallel to the xy plane).Cter and Nter are the C-terminal and N-terminal structural ... pancre-atic RNase A, the superfamily prototype, has interested and intriguedinvestigators. Their ribonucleolytic activity is essential for their cytotoxicaction, and their target RNA is in the cytosol. ... that endocytosed sem-inal RNase is found in endosomes both in malignant and normal cells, but only in malignant cells does the RNase reaches the trans-Golgi network, and then the cytosol, where...

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