Báo cáo khoa học: Calmodulin-mediated regulation of the epid

Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc

... [72]. The binding of these proteins could prevent the interaction of the Ca 2+ ⁄ CaM complex to the receptor if the CaM- BD were occluded at least in part. Nevertheless, the docking of these ... activation of the EGFR, where the C-terminal lobe of the kinase domain of one of the monomers forming the dimeric receptor interacts with the N-terminal lobe...

Ngày tải lên : 06/03/2014, 09:22

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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc

... interesting that the )10 sequence is located inside the iron box of desA (nucleotides 7–12 of the iron box), explaining the regulation of desA expression by binding of DmdR1 to the iron box. The same ... at 24 h. The coordinated regulation by iron of the expression of the entire cluster ensures simple and efﬁcient up -regulation of desferrioxamine biosyn...

Ngày tải lên : 16/03/2014, 11:20

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Báo cáo khoa học: Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins Implications in mechanical stress-associated pathologies pptx

... by the cells results in profound alterations of the histo- morphometry, phenotype and function of the cells [3–7]. The onset of this process is characterized by the activation of a cascade of ... not clear whether there are any speciﬁc regulators at the receptor level of signal transmission, or whether targeting of Cyr61 and CTGF is achieved by speciﬁc cofactors at...

Ngày tải lên : 30/03/2014, 10:20

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Tài liệu Báo cáo khoa học: Evolutionary relationships of the prolyl oligopeptidase family enzymes docx

... ancestor of life. With respect to the studied enzymes of the POP family, POP seems to be the most conserved enzyme. Ten conserved amino acids were found at the active site of the enzyme of each of the ... proposed that the b-propeller of P. furiosus POP does not perform the same function as the mammalian enzyme, i.e. the exclusion of large peptides from the...

Ngày tải lên : 19/02/2014, 13:20

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Báo cáo khóa học: Direct electrochemistry of the Desulfovibrio gigas aldehyde oxidoreductase docx

... process, the assignment of the cofactors involved was possible from a thorough analysis of the voltammetric responses and the structural properties of the molecular surface of DgAOR. Many factors ... the logarithm of CV cathodic and anodic peak currents with the logarithm of the scan rate; (B) variation in the CV cathodic and anodic peak potentials with the log...

Ngày tải lên : 07/03/2014, 15:20

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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx

... role in the traﬃcking of growth factor/ receptor complexes through early endosomes. Stimulation of cells with epidermal growth factor (EGF) rapidly leads to phosphorylation of Hrs, raising the question ... serum-starved andstimulatedwithEGForTGFa before the cells were washed and Hrs was immunoprecipitated from the lysate. We chose to stimulate the cells with the...

Ngày tải lên : 17/03/2014, 11:20

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Tài liệu Báo cáo khoa học: Redox regulation of dimerization of the receptor proteintyrosine phosphatases RPTPa, LAR, RPTPl and CD45 pdf

... conditions. The ectodo- mains of both monomers in the dimer are required for this effect, suggesting that the epitope tag of one monomer is masked by the ectodomain of the other monomer in the dimer, ... of oxidation of the catalytic site cysteines. Taken together, these limited tryptic proteolysis suggest that oxidation induced a change in conformation of the intr...

Ngày tải lên : 18/02/2014, 17:20

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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx

... 6). On the other hand, knockdown of either HO-1 or HO-2 expression resulted in the accumulation of heme in the hemin- treated HepG2 cells. Taken together with the siHO-2- mediated induction of HO-1 ... The intracellular concentration of heme is maintained by the rate of its synthesis and degrada- tion [1]. Many enzymes and their regulators are responsible for heme synthe...

Ngày tải lên : 19/02/2014, 05:20

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Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt

... with BMAL1 and the bin ding to the E-box. Substitution of Arg65 for Ala abolished the interaction of DEC1 with BMAL1 and the binding of DEC1 to the E-box. However, substitution of His57 for Ala ... increase in the mutant mice, the disruption of DEC1 might be compensated by DEC2. Further investigation is required to clarify the functions of DEC1 and DEC2. The supp...

Ngày tải lên : 19/02/2014, 16:20

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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx

... another site, so that the phosphorylation kinetics of one residue can depend on the phosphorylation state of other residues in the protein [8]. It is not clear how these factors modulate the response ... modiﬁcations of proteins are the rule rather than the exception [3,4]. Proteins phosphorylated at several sites include, for example, membrane receptors, such as epiderma...

Ngày tải lên : 07/03/2014, 10:20

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