Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes pot

Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes pot

Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes pot

... envelope One of the goals of the present study was to deter- mine the cleavage sites of hatching enzyme on egg envelope proteins. The natural substrate of hatching enzyme is fertilized egg envelope ... discuss the mechanism of egg envelope digestion by hatching enzyme, mainly based on the structural characteristics of egg envelope prote...
Ngày tải lên : 06/03/2014, 02:20
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Báo cáo khoa học: Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes docx

Báo cáo khoa học: Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes docx

... accompa- nied by a reduction in the amount of cytosolic Sp1. In order to determine whether glutamine increases the binding of Sp1 to the SREBP-1a promoter region containing the Sp1-binding elements, we performed ... containing a mutated sequence of the SRE, pSQS containing the human SQS promoter, pSQS SREKO containing two mutated SREs, pLDLR containing the human LDL re...
Ngày tải lên : 28/03/2014, 22:21
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Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot

Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot

... with other macromolecules as part of the PCSK9-mediated degradation of the LDLR. A cluster of residues on the conserved protrusion is involved in the binding of PCSK9 to the EGF-A domain of the LDLR, ... detected in any urochordate, e.g. in the fairly well-studied Ciona intestinalis, or in any other invertebrates. The C-terminal domain of PCSK9, the CRD,...
Ngày tải lên : 23/03/2014, 07:20
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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

... To distinguish total binding from non-specific binding, cells were incubated for 10 min in either PBSCM alone or PBSCM containing 200 lm cocaine for inhibition of DAT or 200 lm S-citalopram for inhibition ... Values are the mean of six replicates. The specific uptake was determined by subtracting the uptake counts in the absence of inhibitor from the uptake counts in the...
Ngày tải lên : 14/02/2014, 21:20
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... 2A). The zinc ions are required for the structural integrity of the protein, as mutation of any of the cysteine residues involved in zinc coordina- tion results in protein unfolding [22]. The ... include the MLL1 CXXC domain [22], a portion of the MLL1 TAD bound to the KIX domain of the cAMP response element-binding (CREB) binding protein (CBP) [23], a peptide...
Ngày tải lên : 16/02/2014, 14:20
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... examining the role of GIF in AD, linked to its initial discovery as a factor deficient in the AD brain. There remains no clear con- sensus on the role of GIF in the pathogenesis of AD, and therefore ... in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularly within the injured or diseased brain. In the cas...
Ngày tải lên : 16/02/2014, 15:20
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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf

Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf

... repre- sent the last subunits incorporated into the bc 1 com- plex. On the other hand, the absence of Qcr9p in the DQCR9 ⁄ DQCR10 strain prevented the binding of ISP (Fig. 4B). Interestingly, in the ... comparable amounts in both yeast strains. Therefore, the reason for the disap- pearance of the bc 1 dimer in the yeast strain in which Qcr10p is missing r...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt

Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt

... and GH13 enzymes is the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to the a3-helix [9,21]. Sharing domain B by rBATs and GH13 enzymes, and ... domain, including domain B and the C-terminal domain C for rBAT proteins (669 residues on average); (b) the cata- lytic TIM barrel domain, including domain B and the C-termi...
Ngày tải lên : 18/02/2014, 13:20
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Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc

Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc

... from C. intestinalis expressed in vitro and native enzyme expressed in vivo indicates the enzyme is AChE To determine the nature of the cholinesterase activity of the recombinant C. intestinalis enzyme ... with the PRAD domain of ColQ indicates that the WAT domain of the C. intestinalis AChE is capable of organizing the sub- units into a tetramer through in...
Ngày tải lên : 18/02/2014, 17:20
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Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt

Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt

... responsible for the calcium binding [8], we hypothesize that this bind- ing event takes place at the C2 domain. A second calcium-binding site of lower affinity at the C2 domain (corresponding to the dissociation constant ... belongs to the C2 domain (141 amino acids) with its extended loops, whereas the lid-like region at the top represents another flexible part of the struc...
Ngày tải lên : 19/02/2014, 02:20
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