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Báo cáo khoa học: How a lipid mediates tumour suppression Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden pdf

Báo cáo khoa học: How a lipid mediates tumour suppression Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden pdf

Báo cáo khoa học: How a lipid mediates tumour suppression Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden pdf

... 2010 The Author Journal compilation ª 2010 FEBS THE SIR HANS KREBS LECTURE How a lipid mediates tumour suppression Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden Harald ... entail activation of autophagy, a catabolic pathway that isconsidered to mediate tumour suppression by scavenging damaged organ-elles that would otherwise cause DNA instability through the ... subunitsUVRAG and ATG14 can assemble in a competitivemanner (Fig. 1A) . In addition, the UVRAG containingcomplex can associate with Rubicon, a protein thatnegatively regulates the function of this...
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Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx

Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx

... mechanisms that control the chromatin structure and transcriptional activity of rRNA genes, in particu-lar the role of noncoding RNA in DNA methylation and transcriptionalsilencing.AbbreviationsAMPK, ... dur-ing the last two decades has shown that regulation ofrDNA transcription is manifested by multiple pathwaysthat either act synergistically or operate in parallel. The combination of these ... molecular path-ways that transmit information on the growth state of a cell population to the Pol I transcription apparatusrepresents a challenging and rewarding subject ofresearch. The Pol I transcription...
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Báo cáo khoa học: A decade of Cdc14 – a personal perspective Delivered on 9 July 2007 at the 32nd FEBS Congress in Vienna, Austria pdf

Báo cáo khoa học: A decade of Cdc14 – a personal perspective Delivered on 9 July 2007 at the 32nd FEBS Congress in Vienna, Austria pdf

... CDKinactivation A question that arises from the observation that at least two pathways control Cdc14 localization is whybudding yeast utilizes two pathways rather than one toregulate Cdc14? One ... the metaphase–anaphase transition, Separ-ase, a protease that triggers the separation of sisterchromatids at the metaphase–anaphase transition [46]also regulates cyclin degradation and hence ... case. Cdc14 is the phosphatase thatdephosphorylates Cdh1. Its inactivation has the mostdramatic effect on Clb cyclin degradation. CDC15 is a component of one of the two pathways that activateCdc14....
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Báo cáo khoa học: Pharmacology of vascular endothelium Delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw pptx

Báo cáo khoa học: Pharmacology of vascular endothelium Delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw pptx

... should have been. At the time, Bk was per-ceived as a mediator of pain and in ammation respon-sible for paralytic vasodilatation in the course of acutepancreatitis. The reasoning was as follows: ... PGI2-dependent mechanism [79]. In cultured bovine aorticendothelial cells lipophylic statins, i.e. atorvastatin,simvastatin and lovastatin (but not a hydrophilicpravastatin) at a concentration of 30 ... vascular pathology in atherothrombotic and diabetic angiopathies, pre-eclampsia and hypertension (46). Elevated plasma lev-els of ADMA in those patients may also explain the ‘arginine paradox’,...
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Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx

Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx

... transcription factors in mediating the stress response. This is further substantiated bycomputational interactome data that predict theirinteraction [63]. Interestingly, the observation thatYap4 and ... Kluveromyces lactis contain a uniquetranscription activation domain N-terminal to the DBD [4,5]. The HSF is a pre-existing transcriptionactivator that binds to an array of a 5-bp heat shockelement ... subcellular localization.Indeed, Kuge et al. [14] demonstrated that Yap1 nuc-lear retention is mediated by the cysteine-rich domain(CRD) located at the C-terminus of the protein whichcontains...
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Báo cáo khoa học: Diversity of human U2AF splicing factors Based on the EMBO Lecture delivered on 7 July 2005 at the 30th FEBS Congress in Budapest pptx

Báo cáo khoa học: Diversity of human U2AF splicing factors Based on the EMBO Lecture delivered on 7 July 2005 at the 30th FEBS Congress in Budapest pptx

... domains in each proteinare aligned with U2AF35, and the similarity(% identity) of these domains in relation toU2AF35is indicated.Table 2. Domain organization of U2AF35and U2AF35-relatedproteins. ... (A) The putative functional domains in each protein are aligned with U2AF65, and the similarity (% identity) of these domains in relation to U2AF65is indicated. (B) The putative functional ... different mammalsrevealed that most of the exon ⁄ intron boundaries arelocated in the same positions as in the humanCAPERa gene and the introns are found to be smaller in the CAPERb gene. Given the...
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Báo cáo khoa học: Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw pptx

Báo cáo khoa học: Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw pptx

... regulation ofaerobic metabolism and the induction of cell death, and new insight into the regulatory mechanisms operating in vivo.AbbreviationsAGC, aspartate ⁄ glutamate metabolite carrier; ... truncatedmutants lacking the Ca2+-binding domain [33].Substantial evidence has built up in recent yearsindicating that metabolic regulation is only one of the roles of the mitochondrial Ca2+signal. ... mitochondria act as a ‘firewall’that shields some cell domains from the Ca2+signalelicited by submaximal agonist stimulation. This wasclearly shown in pancreatic acinar cells, in which onlyhigh...
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Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx

Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx

... showed that the p53 pathwayacts not only as a tumor suppressor, but also sup-presses iPSC generation as determined using smallinterfering RNA and p53 mutation [89]. These findingsindicate the ... studies have indi-cated that the placenta acts as an additional extrame-dullary hematopoietic organ during embryonic andfetal development [52,53]. Hematopoietic precursorsfound in the human placenta ... limits on cell availability, are a promisingsource of cells, but detailed investigation is required toenable their application in clinical situations. In vitrodifferentiation of hESCs to hematopoietic...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf

Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf

... present during the incubation (data not shown).As Cat only partially prevented enzyme inactivation,EhPFOR inactivation by H2O2was examined in detail. The enzyme was strongly inhibited in a dose-dependentmanner ... DaPFOR,which is naturally resistant to inactivation under aero-bic conditions, contains an extra domain at the C-ter-minal region that spans the vicinal subunit of the dimer and that overlays the Fe–S ... indicatedthat, under saturating O2conditions, the enzyme wasfully inactivated after a short incubation (30 min). At this time, EhPFOR inactivation could be reversed to a great extent by incubation...
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Báo cáo khoa học: Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling Delivered on 24 October 2002 at the 28th FEBS Meeting in Istanbul potx

Báo cáo khoa học: Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling Delivered on 24 October 2002 at the 28th FEBS Meeting in Istanbul potx

... within the ERK activation loop TEYmotif is sufficient for total kinase inactivation [39], numer-ous phosphatases could be implicated in the two phases ofinactivation: the rapid initial phase and ... cooperate to confer strong and specificbinding for each MAPK-interacting molecules [28 ,29] . The spacing and organization of these different motifs on the different MAPK interacting proteins is a feature ... ofERK inactivation. If the activation of the ERK module ismaintained (ER-Raf construct, activatable by tamoxifen),ERKs remain in the nucleus [52]. Non-mitogenic stimuliinduce the initial nuclear...
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