Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... upregulates the expres-
sion of the mitochondrial protein uncoupling protein 2 (UCP2), and pre-
treatment with vitamin E attenuates upregulation of UCP2. These findings
suggest that the MDP-induced reactive ... (20 11) 3054–3064 ª 20 11 The Authors Journal compilation ª 20 11 FEBS
Muramyl-dipeptide-induced mitochondrial proton leak in
macrophages is...
... young seedlings and vascular tissues of leaves, such
as the midrib of the cotyledon, the hypocotyl, and the
root vasculature (Fig. 2E). When the plants were
2 weeks old, the GUS staining in the vascular ... Journal 27 8 (20 11) 22 96 23 06 ª 20 11 The Authors Journal compilation ª 20 11 FEBS 22 97
In order to investigate the detailed expression pat-
tern...
... 3. Distribution and frequency of EGFR
mutations occurring in the kinase domain in
lung cancer (upper part of the figure) [ 12]
and in the extracellular domain in glioblas-
toma (lower part of the ... corresponding to domains
I and II. In this case, the EGFR tyrosine kinase is acti-
vated constitutively without ligand binding, as in the
case of EGFR vI. E...
... genotype-directed
therapy in this disease.
KRAS mutation as a mechanism of
resistance to EGFR-targeted therapy
The KRAS protein is localized to the inner surface of
the cell membrane. The binding of ligand to EGFR
induces ... result in reposition-
ing of critical residues surrounding the
ATP-binding cleft of the tyrosine kinase
domain of the receptor and th...
... mitogen-activated
protein kinase kinase family after being delivered to the cytosol by the cell-
binding component of the toxin, protective antigen. The effect of cleaving
these mitogen-activated protein kinase ... mutations, K518E and E682G (Fig. 1A). Lys518
is within a patch of amino acids that has previously
been implicated in binding MAPKKs [22 ]. Glu6 82 is
wit...
... that
includes a DNA-binding domain, a ligand-binding
domain and a transactivation domain. The DNA-bind-
ing domain is responsible for DNA binding specificity
and dimerization, and the ligand-binding ... as E2F family proteins. Whereas MLL1
interacts with E2F2, E2F4 and E2F6, MLL2 interacts
with E2F2, E2F3, E2F5 and E2F6 [34]. Similar to
E2Fs, the G
1
-phase regulator HCF-...
... functions of the MLL protein
The MLL protein has been identified as the mamma-
lian orthologue of the Trithorax protein in inverte-
brates [6]. Disruption of this gene in invertebrates and
vertebrates ... signature that is further enhanced by
the presence of the HoxA9 protein [20 ]. Men1 binds
directly to the N-terminus of MLL fusions [22 ] and
was ess...
... 5-bromo-4-chloro-3-indolyl-b-
D-galactopyranoside.
527 2 FEBS Journal 27 5 (20 08) 527 2– 528 5 ª 20 08 The Authors Journal compilation ª 20 08 FEBS
simplex virus glycoproteins, gB, glycoprotein H (gH),
and glycoprotein ... (2% formaldehyde and 0 .2% glutaradehyde). The
cells were then washed with NaCl ⁄ P
i
and permeabilized with
2mm MgCl
2
, 0.01% deoxycholate and 0. 0...
... bonding between the imidazole nitrogen of
the conserved His and the hydroxyl of the active-site
Ser increases the nucleophilicity of the Ser oxygen,
facilitating attack of the hydroxy group on the ... condensation
of tetraethoxysilane (TEOS) have been determined; the
catalytic triad is histidine (His), asparagine (Asn) and
serine (Ser) [4, 12] . In the...