Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx

Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx

Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx

... upregulates the expres- sion of the mitochondrial protein uncoupling protein 2 (UCP2), and pre- treatment with vitamin E attenuates upregulation of UCP2. These findings suggest that the MDP-induced reactive ... (20 11) 3054–3064 ª 20 11 The Authors Journal compilation ª 20 11 FEBS Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is...
Ngày tải lên : 05/03/2014, 23:20
  • 11
  • 430
  • 0
Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx

Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx

... young seedlings and vascular tissues of leaves, such as the midrib of the cotyledon, the hypocotyl, and the root vasculature (Fig. 2E). When the plants were 2 weeks old, the GUS staining in the vascular ... Journal 27 8 (20 11) 22 96 23 06 ª 20 11 The Authors Journal compilation ª 20 11 FEBS 22 97 In order to investigate the detailed expression pat- tern...
Ngày tải lên : 14/02/2014, 18:20
  • 11
  • 786
  • 0
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... 3. Distribution and frequency of EGFR mutations occurring in the kinase domain in lung cancer (upper part of the figure) [ 12] and in the extracellular domain in glioblas- toma (lower part of the ... corresponding to domains I and II. In this case, the EGFR tyrosine kinase is acti- vated constitutively without ligand binding, as in the case of EGFR vI. E...
Ngày tải lên : 16/02/2014, 09:20
  • 8
  • 684
  • 0
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... genotype-directed therapy in this disease. KRAS mutation as a mechanism of resistance to EGFR-targeted therapy The KRAS protein is localized to the inner surface of the cell membrane. The binding of ligand to EGFR induces ... result in reposition- ing of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and th...
Ngày tải lên : 16/02/2014, 09:20
  • 7
  • 511
  • 0
Tài liệu Báo cáo khoa học: An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity pdf

Tài liệu Báo cáo khoa học: An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity pdf

... mitogen-activated protein kinase kinase family after being delivered to the cytosol by the cell- binding component of the toxin, protective antigen. The effect of cleaving these mitogen-activated protein kinase ... mutations, K518E and E682G (Fig. 1A). Lys518 is within a patch of amino acids that has previously been implicated in binding MAPKKs [22 ]. Glu6 82 is wit...
Ngày tải lên : 16/02/2014, 09:20
  • 9
  • 579
  • 0
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... as E2F family proteins. Whereas MLL1 interacts with E2F2, E2F4 and E2F6, MLL2 interacts with E2F2, E2F3, E2F5 and E2F6 [34]. Similar to E2Fs, the G 1 -phase regulator HCF-...
Ngày tải lên : 16/02/2014, 14:20
  • 15
  • 607
  • 0
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

... functions of the MLL protein The MLL protein has been identified as the mamma- lian orthologue of the Trithorax protein in inverte- brates [6]. Disruption of this gene in invertebrates and vertebrates ... signature that is further enhanced by the presence of the HoxA9 protein [20 ]. Men1 binds directly to the N-terminus of MLL fusions [22 ] and was ess...
Ngày tải lên : 16/02/2014, 14:20
  • 10
  • 657
  • 0
Tài liệu Báo cáo khoa học: Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane pdf

Tài liệu Báo cáo khoa học: Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane pdf

... quantities of protein utilizing the principle of protein- dye binding. Anal Biochem 72, 24 8 25 4. Isomerohydrolase activity of purified RPE65 O. Nikolaeva et al. 3030 FEBS Journal 27 6 (20 09) 3 020 –3030 ª 20 09 ... AU) 025 5101 520 Time (min) 1 .2 0 0.8 0.4 A 320 (1 × 10 2 AU) 0.6 0 0.4 0 .2 A 320 (1 × 10 2 AU) 1 .2 0.8 025 5101 520 Time (min) 0.6 0 0.4 0 .2 A 3...
Ngày tải lên : 18/02/2014, 08:20
  • 11
  • 587
  • 0
Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx

Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx

... 5-bromo-4-chloro-3-indolyl-b- D-galactopyranoside. 527 2 FEBS Journal 27 5 (20 08) 527 2– 528 5 ª 20 08 The Authors Journal compilation ª 20 08 FEBS simplex virus glycoproteins, gB, glycoprotein H (gH), and glycoprotein ... (2% formaldehyde and 0 .2% glutaradehyde). The cells were then washed with NaCl ⁄ P i and permeabilized with 2mm MgCl 2 , 0.01% deoxycholate and 0. 0...
Ngày tải lên : 18/02/2014, 14:20
  • 14
  • 672
  • 0
Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc

Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc

... bonding between the imidazole nitrogen of the conserved His and the hydroxyl of the active-site Ser increases the nucleophilicity of the Ser oxygen, facilitating attack of the hydroxy group on the ... condensation of tetraethoxysilane (TEOS) have been determined; the catalytic triad is histidine (His), asparagine (Asn) and serine (Ser) [4, 12] . In the...
Ngày tải lên : 18/02/2014, 16:20
  • 9
  • 576
  • 0

Xem thêm

Từ khóa: