... composition arebasically the same in aging and disease.In a lysosome, where different organelles and a variety of proteins and other macromolecules are degraded, the milieu is acidic and reducing, partly ... recyclingmechanisms are inherently imperfect [15,25], and this mayprovide an attractive explanation for many of the features of aging. A number of early explanations of aging, such as Orgel’s error catastrophe ... dismutase,catalase, glutathione peroxidase, vitamin E, and otherantioxidant defense systems reduce, but do not prevent,macromolecular damage such as single- and doubleDNA-strand breaks, DNA–protein and...