... Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphataseKonstantinos Mavromatis1,*, Iason Tsigos2,*, Maria Tzanodaskalaki2, Michael Kokkinidis1,3and Vassilis ... levels of Pro and Argresidues, weakening of intramolecular interactions,increased solvent interactions, decreased charged residuesinteractions, and disulfide bonds [1,2,17]. Increased levels of Gly ... wholeprotein structure are involved and not just the intrinsicflexibility of Gly residues [20].We have recently reported the cloning, sequencing andoverexpression of the gene encoding alkaline phosphatasefrom...