Tài liệu Báo cáo Y học: Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils pot
... AA-SF).
3766 A. N. Fonteh (Eur. J. Biochem. 269) Ó FEBS 2002
Differential effects of arachidonoyl trifluoromethyl ketone
on arachidonic acid release and lipid mediator biosynthesis
by human neutrophils
Evidence ... studies by demon-
strating that inhibition of LTB
4
and PAF biosynthesis by
AACOCF
3
occurs without concomitant inhibition of AA
relea...
... that affect myc
gene expression, Myc protein stability, and Myc bio-
logical activity. Normal regulation of Myc activity
occurs by mechanisms that influence the Myc protein
per se [7], and also through ... converts Mxi1-SRa into a
potent suppressor of Myc ⁄ Ras cotransformation activ-
ity (Fig. 3) and also changes the activity of Mxi1-SRa
activity on the MYC promoter from activ...
... phospholipid bilayer/
water partition coefficient, the localization and orientation
in the phospholipid bilayer, and the effects of the presence
of these peptides on phospholipid organization and ... studies
of GS/phospholipid bilayer interactions considerably.
Specifically, we have investigated the strength and nature
of the interactions of GS with phospholipid bilayers...
... main line of evidence for the existence of a POR-
phosphatase is the observation by Wiktorsson et al. [9] of an
inhibition, by NaF and ATP, of the loss of the long-
wavelength form of Chlide ... aggregated form of
a phosphorylated (or possibly adenylated) ternary complex
of POR, its substrate PChlide, and NADPH. Dephospho-
rylation of the photoconverted form of thi...
... differences.
Neuronal differentiation of PC12 cells by Hyper-CNTF
In a second bioassay, we investigated the potential role
of Hyper-CNTF in neuronal cell differentiation. The
morphology of rat pheochromocytoma ... 2002
STAT3 and MAPK activation by Hyper-CNTF
in transfected BAF/3 cells
Downstream signal transduction pathways were analyzed
by studying the activation level of JAK...
... as a standard.
Enzyme activity
The enzyme activity of TIM was determined by the conver-
sion of glyceraldehyde 3-phosphate to dihydroxyacetone
phosphate in the presence of TIM and a-glycerolphosphate
dehydrogenase ... uncatalyzed rates of
enolization of dihydroxyacetone phoshate and of
glyceraldehyde 3-phosphate in neutral aqueous
solution. The quantitative assessment of t...
... cells.
Inhibitory effects of VVA1 on the hemolytic and
cytotoxic activity of VVA2
The effects of VVA1 on the hemolytic activity of
VVA2 were studied by incubation of human red blood
cells (RBCs) with the ... Extending
these results, we hypothesized that the inhibition of
VVA2 cytotoxic pore formation by VVA1 can only
occur at the ideal ratio of 2 : 1 or lower, du...
... devoid of resistance induction, due to
the evolutionary stability of histones, and more partic-
ularly histone H4 [32]. Interestingly, mutations at
codon 751 of the E. coli gyrB gene conferred ... activity, as its replacement by
Gly in HNb is most likely responsible for its relatively
low potency (LD
50
: 88.3 lgÆmL
)1
). Interestingly, the
antimicrobial potency of HNb could be im...
... properties (concentration and, as a
consequence, total activity) of an enzyme can be chan-
ged by affecting rates of transcription and ⁄ or transla-
tion and ⁄ or mRNA and protein degradation. This
represents ... origin of highly homologous gene
paralogs of skeletal LDH-A in the weatherfish.
Many bony fish (Teleostei) are polyploidy, for exam-
ple salmonids (Salmonidae) and c...
... translation
indirectly by inhibition of mRNA synthesis during amino
acid starvation [20–23].
Kirromycin is one in a family of antibiotics that inhibits
protein synthesis by binding EF-Tu–GTP and preventing
the ... translation
in vitro was determined by poly(U)-directed polymerization
of phenylalanine in the polymix system, as described by
Ehrenberg et al. [42] and modified...